New universal flu vaccine enters human testing

NCT ID NCT07215858

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 34 times

Summary

This study tests an experimental flu vaccine called BPL-1357, given as a shot or nasal spray, to see if it is safe and can protect against multiple flu types. About 129 healthy adults aged 18-55 will receive the vaccine or a placebo, then be exposed to a flu virus in a controlled setting. The goal is to find a vaccine that works against seasonal and pandemic flu strains.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BPL-1357 (a whole-virus flu vaccine given as a shot or nasal spray)
What this could lead to: If successful, this vaccine could provide broader protection against different flu strains, potentially helping to prevent future flu pandemics.
What could go wrong: This is an early phase 2 trial with only 129 participants, so results may not apply to everyone. The vaccine may not work as hoped, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HUMAN are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

human disease influenza swine influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUMAN INFLUENZA

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States
University of Texas Medical Branch, Galveston
NOT_YET_RECRUITING

Galveston, Texas, 77555, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.