Multiple organ dysfunction syndrome

This study tested a drug called GM-CSF in 75 children with sepsis who had a weakened immune system (immunoparalysis) and organ failure. The goal was to see if the drug could restore their immune response and find the best dose and way to give it (by IV or injection). The study fo…

This study tested a new medical device called MEX-CD1 in 11 adults with acute-on-chronic liver failure (ACLF), a serious condition where the liver suddenly stops working. The device works like a dialysis machine to filter excess iron from the blood. The main goals were to see if …

This study tested a drug called GM-CSF in 141 children with sepsis who had multiple organ failure and a weakened immune system. The goal was to see if the drug could help their organs recover better than a placebo. The trial is complete, and results will show if this approach imp…

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tested whether adding a special blood filter called CytoSorb to standard ECMO support helps people with cardiogenic shock (a severe form of heart failure). The filter aims to remove inflammatory substances from the blood. Researchers measured how much heart-support med…

This study tested a device called HA-380® that filters inflammatory substances from the blood during heart-lung bypass in complex cardiac surgeries. Forty-one adults undergoing high-risk procedures like heart transplants or aortic dissection repairs were enrolled. The goal was to…

This study tested whether a non-invasive arm cuff procedure, called remote ischemic conditioning, could reduce organ failure in 180 adults with septic shock. The cuff was inflated and deflated in cycles to mimic brief blood flow restriction. The goal was to see if this could prot…

This pilot study tested whether manual lymphatic drainage, a gentle massage technique, is safe and feasible for patients recovering from septic shock. Researchers enrolled 24 adults in the ICU and compared those who received the massage plus usual care to those who received usual…

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This completed study exposed 27 healthy young adults to either high heat (35°C) or moderate temperature (24°C) for three hours. Researchers measured changes in blood pressure, heart function, and lung capacity to understand how heat stress affects the body. The goal was to uncove…

This study examined 236 adults in a surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was linked to how long they stayed on the ventilator. The goal was to b…

This observational study looked at how a cold preservation solution is given to deceased organ donors after a special blood flow procedure. The goal was to create a standard way to do this. Researchers studied 20 donors to see how fast the solution was given, how long it took, an…

This study examined over 1,200 adults admitted to an intensive care unit to see if the reason they were admitted (like sepsis or breathing failure) could predict their risk of dying in the ICU, beyond what standard severity scores show. Researchers looked back at medical records …

This study examined 185 intensive care patients to understand how common venous congestion (a backup of blood in the veins) is and whether it contributes to organ problems like kidney or liver failure. Researchers used blood tests and ultrasound to check for signs of congestion. …

This study looked at 100 children in Congo with severe malaria to see if computer models could predict who might die. Researchers used blood tests and other data to build machine-learning algorithms. The goal is to help doctors make faster, better treatment decisions for the sick…

This study looked at 380 adults in the intensive care unit with suspected or confirmed COVID-19. Researchers tracked organ problems like kidney injury and lung failure, and measured survival rates at 30 days and one year. The goal was to learn how COVID-19 causes organ damage, no…

This study looked at whether doing an early heart ultrasound (echocardiography) in the emergency department helps doctors manage sepsis or septic shock better. 312 adults with sepsis were randomly assigned to either get the ultrasound plus a treatment guide, or standard care. The…