Can a drug wake up the immune system in kids with sepsis?
NCT ID NCT03769844
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a drug called GM-CSF in 75 children with sepsis who had a weakened immune system (immunoparalysis) and organ failure. The goal was to see if the drug could restore their immune response and find the best dose and way to give it (by IV or injection). The study focused on measuring immune function, not long-term cure or survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Benioff Children's Hospital/UCSF
San Francisco, California, 94158, United States
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Children's Hospital of Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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UCLA Mattel Children's Hospital
Los Angeles, California, 90095, United States