Could a simple drug shield organs after aortic tear surgery?

NCT ID NCT07156656

Not yet recruiting Disease control Sponsor: Shanghai Zhongshan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a drug called sivelestat sodium can reduce organ damage in people who have emergency surgery for a torn aorta (type A aortic dissection). About 236 patients will receive either the drug or a placebo for 3 days after surgery. The main goal is to see if the drug improves a score that measures how well multiple organs are working.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sivelestat sodium
What this could lead to: If it works, this could point toward a new way to protect organs after major heart surgery, potentially reducing complications and improving recovery.
What could go wrong: This is a relatively small, early-phase 4 trial. The drug may not show a meaningful benefit over standard care, and there is always a risk of side effects like allergic reactions or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

familial thoracic aortic aneurysm and aortic dissection multiple organ dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORGAN FAILURE, MULTIPLE TYPE A AORTIC DISSECTION

Contacts and locations

Locations

Changhai Hospital of Shanghai

Shanghai, Shanghai Municipality, China
Fujian Provincial Hospital

Fuzhou, Fujian, China
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) (Guangdong Provincial People's Hospital Affiliated to Southern Medical University)

Guangzhou, Guangdong, China
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China
The First Affiliated Hospital of Xi'an Jiao Tong University

Xi'an, Shaanxi, China
The University of Hong Kong - Shenzhen Hospital

Shenzhen, Guangdong, China

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