Could a simple drug save kids from sepsis organ failure?

NCT ID NCT05267821

Recruiting now Disease control Sponsor: Nationwide Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether anakinra, a drug that blocks inflammation, can help children with sepsis who are experiencing multiple organ failure. The trial will involve 500 children in intensive care, comparing anakinra to a placebo. The goal is to see if the drug can reduce organ damage and improve quality of life after recovery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Anakinra (a drug that blocks inflammation)
What this could lead to: If successful, this could provide a new treatment to reduce organ damage and improve survival in children with severe sepsis.
What could go wrong: This is a mid-stage trial, so results are not guaranteed. Anakinra may not work better than placebo, and could have side effects like increased infection risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

multiple organ dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC SEPSIS-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS)

Contacts and locations

Locations

Akron Children's Hospital
RECRUITING

Akron, Ohio, 44308, United States
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202, United States
Benioff Children's Hospital - Mission Bay
RECRUITING

San Francisco, California, 94143, United States
Benioff Children's Hospital - Oakland
RECRUITING

Oakland, California, 64609, United States
CS Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Atlanta
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States
Children's Hospital of Minnesota
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Hospital of Orange County
NOT_YET_RECRUITING

Orange, California, 92868, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15260, United States
Children's Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78207, United States
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Duke University
RECRUITING

Durham, North Carolina, 27705, United States
Medical College of Wisconsin
NOT_YET_RECRUITING

Milwaukee, Wisconsin, 53233, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Mercy Children's Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Pennsylvania State University
RECRUITING

Hershey, Pennsylvania, 17033, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84158, United States
Rady Children's Hospital
RECRUITING

San Diego, California, 92123, United States
Rainbow Babies and Children's Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
Riley Children's Hospital
RECRUITING

Indianapolis, Indiana, 46204, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
University of California, Davis
RECRUITING

Sacramento, California, 95817, United States
University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States