Could a simple drug save kids from sepsis organ failure?
NCT ID NCT05267821
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether anakinra, a drug that blocks inflammation, can help children with sepsis who are experiencing multiple organ failure. The trial will involve 500 children in intensive care, comparing anakinra to a placebo. The goal is to see if the drug can reduce organ damage and improve quality of life after recovery.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Anakinra (a drug that blocks inflammation)
What this could lead to
If successful, this could provide a new treatment to reduce organ damage and improve survival in children with severe sepsis.
What could go wrong
This is a mid-stage trial, so results are not guaranteed. Anakinra may not work better than placebo, and could have side effects like increased infection risk.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Akron Children's Hospital
RECRUITINGAkron, Ohio, 44308, United States
Contact Email: •••••@•••••
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Arkansas Children's Hospital
RECRUITINGLittle Rock, Arkansas, 72202, United States
Contact
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Benioff Children's Hospital - Mission Bay
RECRUITINGSan Francisco, California, 94143, United States
Contact
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Benioff Children's Hospital - Oakland
RECRUITINGOakland, California, 64609, United States
Contact
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CS Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
Contact
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Children's Hospital of Atlanta
RECRUITINGAtlanta, Georgia, 30329, United States
Contact Email: •••••@•••••
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Children's Hospital of Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
Contact
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Children's Hospital of Michigan
RECRUITINGDetroit, Michigan, 48201, United States
Contact Phone: •••-•••-••••
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Children's Hospital of Minnesota
NOT_YET_RECRUITINGMinneapolis, Minnesota, 55404, United States
Contact
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Children's Hospital of Orange County
NOT_YET_RECRUITINGOrange, California, 92868, United States
Contact
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Email: •••••@•••••
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Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15260, United States
Contact Email: •••••@•••••
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Children's Hospital of San Antonio
RECRUITINGSan Antonio, Texas, 78207, United States
Contact Email: •••••@•••••
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University
RECRUITINGDurham, North Carolina, 27705, United States
Contact
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Medical College of Wisconsin
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53233, United States
Contact
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
Contact Email: •••••@•••••
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Mercy Children's Hospital
RECRUITINGKansas City, Missouri, 64108, United States
Contact
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Pennsylvania State University
RECRUITINGHershey, Pennsylvania, 17033, United States
Contact
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84158, United States
Contact
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Rady Children's Hospital
RECRUITINGSan Diego, California, 92123, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Rainbow Babies and Children's Hospital
RECRUITINGCleveland, Ohio, 44106, United States
Contact Email: •••••@•••••
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Riley Children's Hospital
RECRUITINGIndianapolis, Indiana, 46204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact
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University of California, Davis
RECRUITINGSacramento, California, 95817, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75390, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298, United States
Contact