Beth Israel Deaconess Medical Center

This study tested a new type of vaccine made by fusing a patient's own immune cells with their cancer cells. The goal was to see if it was safe and could help the immune system fight advanced melanoma. Twenty adults with spreading melanoma that was getting worse took part. The va…

This trial tests whether giving intravenous thiamine (vitamin B1) alongside standard treatment helps people with diabetic ketoacidosis recover faster. Diabetic ketoacidosis is a serious condition where the blood becomes too acidic. The study includes adults hospitalized with this…

This study tested whether providing home-delivered DASH diet groceries, with help from a dietitian, could lower blood pressure in Black adults living in urban areas with limited access to healthy food. 180 participants with elevated blood pressure but not on medication took part.…

This study tests the drug abatacept in people with chronic graft-versus-host disease (cGVHD) that is not controlled by steroids. cGVHD is a condition where donor immune cells attack the recipient's body after a stem cell transplant. The trial has two phases: first, to find a safe…

This study tested a personalized vaccine made from a patient's own tumor cells fused with immune cells (dendritic cells) to treat stage IV kidney cancer. The vaccine was given with a drug called GM-CSF to boost immune response. The main goal was to check safety and side effects i…

This study tested whether cisplatin, a platinum-based chemo, works better than the standard doxorubicin/cyclophosphamide (AC) combo in women with newly diagnosed breast cancer who carry a BRCA mutation. 118 participants received either cisplatin or AC before surgery. The main goa…

This study tested a drug called CT-011 (a PD-1 blocker) and a dendritic cell vaccine given after a stem cell transplant in 35 people with multiple myeloma. The goal was to see if this combination is safe and can boost the immune system to fight remaining cancer cells. Researchers…

This study tested a drug called GO-203-2C, which targets a protein (MUC1) found on cancer cells while sparing healthy cells. It was given alone or with another drug (decitabine) to 33 adults with acute myeloid leukemia that had returned or not responded to treatment. The main goa…

This study looked at whether using a HEPA air purifier at home can improve lung health in adults with a type of COPD called eosinophilic COPD. 178 people took part, with half getting real purifiers and half getting fake ones. The main goal was to see if the purifiers helped with …

This study tested a personalized vaccine made from a patient's own tumor cells mixed with immune cells from a healthy donor. The goal was to see if the vaccine is safe and can help the immune system attack advanced kidney cancer. Forty people with stage IV kidney cancer took part…

This study tested whether very low doses of interleukin-2 (IL-2), given as shots under the skin for 4 weeks, could increase regulatory T-cells (Tregs) in liver transplant recipients. The goal was to see if this could eventually allow patients to take fewer immunosuppressant drugs…

This study tested whether zafirlukast, an asthma drug, can slow or stop ovarian cancer in people whose only sign of relapse is a rising CA-125 blood marker. Only 5 participants were enrolled. The main goal was to see if the drug could lower CA-125 levels by at least half for a mo…

This study tested a new imaging technique called restriction spectrum imaging (RSI) to see if it can find breast cancer as well as standard breast MRI. About 460 women who were getting routine breast cancer screening took part. The goal was to compare how accurate RSI is versus c…

This study tested a device that checks for anemia (low iron) in pregnant women without a blood draw. It included 124 pregnant or postpartum adults. The goal was to see if the non-invasive device gives the same results as standard blood tests.

This study tested a new blood test (pDrp1 assay) to measure platelet activity in 112 healthy and severely obese volunteers taking aspirin or clopidogrel. The goal was to see if the new test is as accurate as the current standard test (light transmission aggregometry). Researchers…

This study tested whether giving IV acetaminophen (Tylenol) every 6 hours during and after heart surgery could prevent delirium—sudden confusion—in patients aged 60 and older. Delirium is common after heart surgery and can lead to longer hospital stays and other problems. The tri…

This study tests whether dantrolene, a non-sedating muscle relaxant, can improve pain control and reduce agitation in adults undergoing lumbar fusion surgery. Participants receive either dantrolene or a placebo pill before and after surgery. The goal is to see if dantrolene impro…

This completed phase 2 trial tested whether levetiracetam, a drug used for epilepsy, could reduce abnormal brain overactivity and improve cognitive function in 58 people with early Alzheimer's disease or mild cognitive impairment. Participants received either the drug or a placeb…

This study tested whether giving low-dose nitrous oxide (laughing gas) during a urodynamic study (a test for urinary symptoms) changes key bladder measurements like capacity and pressure. 19 adults scheduled for the test took part. If the measurements stay the same, nitrous oxide…

This study looked at 100 healthy women having a planned or non-labor cesarean delivery to see which drug works better as a first-line treatment to prevent nausea and vomiting after surgery. Participants received either dexamethasone or ondansetron, and researchers tracked how man…

This study tested whether using ultrasound to guide epidural needle placement works better than the traditional method of feeling for landmarks (palpation) in women with labor pain. About 110 healthy pregnant women received an epidural using either ultrasound or palpation. The go…

This study tested whether an ultrasound-guided femoral nerve block (using bupivacaine) works as well as standard opioid painkillers (like morphine) for people with hip fractures in the emergency department. 44 adults with moderate to severe pain were enrolled. The goal was to see…

This study tested a daily synbiotic supplement (DS-01) in 48 adults with irritable bowel syndrome (IBS) to see if it is safe and helps improve gut health. Participants took either the supplement or a placebo for 12 weeks. The main goal was to check for side effects and see how th…

This pilot study tested a brief cognitive behavioral therapy (CBT) program designed to help older adults (55+) safely reduce or stop their use of benzodiazepines, which are commonly prescribed for insomnia and anxiety but can be risky with age. Seventeen participants received the…

This small pilot study looked at whether a 12-week tai chi program is practical and helpful for people with chronic obstructive pulmonary disease (COPD). Ten adults with COPD were randomly assigned to either tai chi or usual care. The study focused on whether tai chi could improv…

This study tested a wearable eye-tracking device called EyeControl-Pro in 160 older, ventilated ICU patients. The device lets patients communicate by moving their eyes, which may help reduce delirium—a state of confusion common in intensive care. Researchers compared patients who…

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and…

This study tested three different doses of spinal morphine (50, 150, or 250 micrograms) to see which provides the longest pain relief after a C-section. 72 healthy women participated, and researchers measured how long until they needed extra pain medication. The goal is to improv…

This study tested a non-invasive brain stimulation technique to reduce mania symptoms in people with bipolar or schizoaffective disorder. Fourteen participants with mild-to-moderate mania received targeted electrical stimulation to brain areas linked to impulse control and risk-t…

This study tested whether a multiport epidural catheter (with three side holes) provides better pain relief than a standard uniport catheter (with one end hole) after chest or upper abdominal surgery. Researchers enrolled 240 adults and measured how often the catheter failed, mea…

This study tested whether the sleep medication suvorexant (Belsomra) can help older adults sleep better and reduce confusion after heart surgery. One hundred patients aged 60 and older received either suvorexant or a placebo for seven nights in the ICU. Researchers measured sleep…

This study tested whether giving high-flow nasal oxygen (HFNO) during upper GI endoscopy in high-risk patients (e.g., those with sleep apnea or obesity) reduces the risk of blood oxygen levels falling too low. 180 patients were randomly assigned to receive either HFNO or standard…

This completed study tested whether a mild electrical current applied to a specific brain region (the right superior temporal sulcus) could reduce hallucinations in 12 adults with psychosis. Participants received transcranial electrical stimulation while researchers measured chan…

This study tested a new tool called a linear cognitive aid to help emergency medical teams treat children during critical situations like cardiac arrest. The tool gives simple, step-by-step instructions based on the child's age and emergency type. Researchers compared teams using…

This study looked at how ketorolac, a non-steroidal anti-inflammatory drug (NSAID) used for pain after cesarean delivery, affects platelet function and blood clotting. Researchers measured clotting in 40 women undergoing scheduled C-sections using special blood tests. The goal wa…

This study looked at whether a 15-minute meditation practice called Shoonya meditation can help people stay sharp after a night without sleep. Researchers compared regular meditators to people who nap regularly, measuring brain activity, heart rate, and cognitive performance. The…

This study looks at whether a 21-minute daily meditation practice called Shambhavi Mahamudra Kriya can improve brain health. Researchers will measure brain activity, brain structure, and thinking skills in 77 adults aged 20-65 over 6 months. The goal is to see if this simple, sea…

This small pilot study looked at whether combining walking with mindful attention is a practical and acceptable way to help people with metabolic syndrome become more active. 34 participants were assigned to a walking program, a mindfulness program, both, or neither. The goal was…

This study tested an AI system called AMIE that talks with patients before their urgent care appointment. About 100 adults had a conversation with the AI, supervised by a doctor for safety. Researchers checked how patients and doctors felt about the AI, the quality of the convers…

This study looked at how galcanezumab, a newer migraine prevention drug, affects the brain. Researchers used MRI scans to see if the drug changes brain structure in people with chronic migraine. The goal was to learn more about where the drug works, not to test if it helps sympto…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study tested a website called 'Decide Together' that helps women aged 75 and older and their primary care doctors talk about the benefits and harms of mammography screening. The goal was to support shared decision-making, not to treat or prevent breast cancer. The study enro…

This study tested a program called InVEST that provides one-on-one support for young people aged 12 to 22 who are at high risk for psychosis. The goal was to see if the program helps them do better at work or school. The study had two parts: first a small test with 8 people to se…

This study looked at whether long-term meditation is linked to a younger 'brain age' and better sleep. Researchers compared 57 meditators who practice Shambhavi Mahamudra Kriya with 51 non-meditators. Participants wore EEG headbands and sleep rings at home for five nights to meas…

This pilot study tested whether a multi-component prehabilitation program—including physical therapy, nutrition counseling, and meditation—is feasible for older adults (70+ or 65+ with high risk) scheduled for major elective surgery. The program aimed to improve strength and reco…

This completed study tested whether using a lower oxygen concentration (70% or 40%) instead of the usual 100% oxygen right before removing a breathing tube reduces lung collapse (atelectasis) after surgery. Forty-eight adults having elective surgery under general anesthesia took …