Simple painkiller may stop Post-Surgery brain fog in seniors
NCT ID NCT04093219
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving IV acetaminophen (Tylenol) every 6 hours during and after heart surgery could prevent delirium—sudden confusion—in patients aged 60 and older. Delirium is common after heart surgery and can lead to longer hospital stays and other problems. The trial enrolled 900 older adults having bypass or valve surgery and compared the drug to a placebo (saline). The goal was to see if this simple, low-cost approach could reduce the risk of postoperative delirium.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IV acetaminophen (Tylenol)
What this could lead to
If it works, this could provide a simple, safe way to prevent delirium after heart surgery in older patients.
What could go wrong
This trial is completed but results may not show a clear benefit; delirium is complex and a single drug may not be enough. Also, the study only included older adults having specific heart surgeries.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Albert Einstein College of Medicine- Montefiore
The Bronx, New York, 10467, United States
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Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35233, United States
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University of California Irvine
Irvine, California, 92697, United States
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University of California Los Angeles
Los Angeles, California, 90095, United States
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University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, 15213, United States
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Yale University/Yale New Haven Hospital
New Haven, Connecticut, 06510, United States