New anesthesia cocktail may cut confusion and pain after heart surgery

NCT ID NCT05279898

Completed Symptom relief Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and a mix of painkillers and sedatives to tailor anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ropivacaine, Ketamine, Remifentanil, Dexmedetomidine
What this could lead to: If successful, this approach could help older adults recover from heart surgery with less confusion, pain, and need for strong painkillers.
What could go wrong: This is a small, completed study (70 people) without a phase, so results may not apply to everyone. The benefits seen might not hold up in larger, more diverse groups.

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Conditions

The condition(s) this trial relates to.

Cognition Disorders cognitive disorder coronary artery disorder Emergence Delirium heart valve disorder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMODYNAMIC INSTABILITY NEUROCOGNITIVE DYSFUNCTION PAIN POSTOPERATIVE DELIRIUM

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02115, United States

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