Beth Israel Deaconess Medical Center

This study tests a personalized vaccine made from a patient's own leukemia cells and immune cells. The goal is to see if the vaccine can help prevent the cancer from coming back after chemotherapy. It is for adults aged 55 and older with acute myeloid leukemia (AML) who are in re…

This study compares fentanyl and hydromorphone (Dilaudid) for sedating patients on mechanical ventilators in the ICU. About 300 adults will be randomly assigned to one of the two drugs. The main goal is to see if one leads to lower total opioid use. The results could help guide s…

This phase 2 trial is testing a higher dose (500 mg) of the hormone therapy fulvestrant (Faslodex) as a first treatment for postmenopausal women with hormone receptor positive metastatic breast cancer. The study aims to see if this higher dose improves clinical benefit rates comp…

This early-phase study tests a custom-made cancer vaccine (DC/AML fusion vaccine) for people with acute myeloid leukemia (AML) who have recently had a stem cell transplant. The vaccine is designed to teach the body's immune cells to recognize and attack remaining leukemia cells. …

This phase 2 study tests nivolumab (Opdivo) in 29 men with high-risk prostate cancer that has returned after initial treatment, shown by rising PSA levels. The drug works by helping the immune system recognize and attack cancer cells. The main goal is to see if nivolumab can cont…

This study uses brain scans (fMRI) to see how the weight-loss drug lorcaserin changes activity in brain areas that control appetite and food intake. Forty obese adults will receive either lorcaserin or a placebo pill. Researchers will also measure changes in body composition. The…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite. Researchers will scan the brains of 28 obese adults to see how they respond to food cues after treatment. The goal is to understand the underlying mechanisms that help p…

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard treatment, with the goal …

This study tests whether providing home-delivered DASH diet groceries, with help from a dietitian, can lower blood pressure in Black adults who already take medication for hypertension and live in areas with limited access to healthy food. About 150 participants will receive week…

This phase 2 study tests the drug olaparib in 114 people with metastatic breast cancer whose tumors have mutations in certain DNA repair genes (like BRCA1, BRCA2, ATM, PALB2, and others). Olaparib is a PARP inhibitor that may kill cancer cells by blocking their ability to fix dam…

This study evaluates different cervical cancer screening methods using HPV testing in Botswana, involving 3000 women aged 25 and older. Researchers compare HPV genotype restriction with visual inspection to find the most accurate way to detect high-grade cervical dysplasia. The g…

This study is testing a computer model called PRISM that uses electronic health records to predict who might develop pancreatic cancer. Researchers will analyze data from over 6 million people aged 40 and older across 44 US healthcare centers. The goal is to see if the model can …

This observational study tests three non-invasive technologies—ultrasound, electrical impedance, and nerve excitability tests—to see if they can reliably diagnose myofascial pain syndrome. Researchers will compare results from 90 people with and without the condition. The goal is…

This study tests a handheld device called the Osteoprobe that measures bone strength by pressing on the shinbone. Researchers want to see if it can identify women at risk for hip and wrist fractures better than standard bone density scans. About 190 women with recent fractures an…

This study looks at whether long-acting HIV prevention shots (CAB-LA) are safe and work well for breastfeeding mothers after childbirth. About 500 new mothers in Botswana will get the shots and be followed for 24 months along with their babies. The goal is to see if this method c…

This study tests a structured team checklist called CMOT for when breathing support is removed from dying ICU patients. The goal is to reduce distress, which occurs in 30-59% of cases. Researchers will enroll 184 patients and ICU staff across four ICUs to see if the checklist is …

This study tests whether an accelerated schedule of transcranial magnetic stimulation (TMS) is safe and effective for treating symptoms of psychotic disorders like schizophrenia. About 20 adults aged 18-65 with schizophrenia, schizoaffective disorder, or at high risk for psychosi…

This phase 2a trial tests whether the drug abrocitinib can reduce severe fatigue in adults with Long COVID. About 46 people who were never hospitalized for COVID but now have long-term fatigue will take either 50 mg, 100 mg of abrocitinib, or a placebo daily for 12 weeks. Researc…

This study looks at whether tai chi exercises and wearable fitness trackers can help people who have survived a heart attack (acute coronary syndrome) become more physically active. About 70 adults who are currently inactive will take part. The goal is to see if this approach is …

This study looks at how different levels of pressure from a breathing machine (called PEEP) affect the heart's pumping ability in 28 adults having heart surgery. Doctors will use special imaging and monitors to measure heart function at four different pressure settings. The goal …

This study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This pilot study tests a bundle of low-intensity ventilation strategies during robotic surgery to see if it reduces lung collapse and breathing complications after surgery. Sixty adults having non-emergency robotic abdominal or pelvic surgery will be enrolled. The study focuses o…

This study will follow 500 patients over age 65 who are receiving a new implantable cardioverter-defibrillator (ICD) for the first time to prevent sudden cardiac arrest. Researchers will track their health, quality of life, and experiences for 18 months, with optional follow-up u…

This study checks if a computer model called LIRIC can accurately predict who will develop liver cancer using electronic health records. Researchers will track 6 million adults aged 40 and older without a history of liver cancer to see how well the model works. The goal is to imp…

This study looks at whether standard hormone therapy (apalutamide, darolutamide, or enzalutamide) can increase the visibility of prostate cancer cells on PSMA PET/CT scans. About 9 men with recurrent prostate cancer will take the hormone pill for a few weeks and then get a scan. …

This study looks at how well air and blood mix in the lungs of 10 adults on a heart-lung bypass machine (VA ECMO). Researchers will adjust the breathing machine settings using special monitoring tools to see if they can improve oxygen levels. The goal is to gather information, no…

This study reviewed records of 70,000 adults who had non-urinary surgery under general anesthesia. It compared two drugs used to reverse muscle relaxants: sugammadex and neostigmine (given with atropine or glycopyrrolate). The goal was to see which drug is linked to fewer cases o…

This study aimed to see if a four-session biofeedback training program could improve trunk control and walking in older adults with and without chronic low back pain. Researchers planned to compare 20 older adults with back pain to 20 healthy volunteers, measuring walking biomech…