Which reversal drug causes fewer bathroom problems after surgery?
NCT ID NCT06948409
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study reviewed records of 70,000 adults who had non-urinary surgery under general anesthesia. It compared two drugs used to reverse muscle relaxants: sugammadex and neostigmine (given with atropine or glycopyrrolate). The goal was to see which drug is linked to fewer cases of postoperative urinary retention, which can delay discharge from the recovery room. The study also looked at costs and unplanned hospital visits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sugammadex or neostigmine (with atropine or glycopyrrolate)
- What this could lead to
- If this study finds one reversal drug causes less urinary retention, it could help doctors choose the safer option for patients after surgery.
- What could go wrong
- This is a retrospective study, meaning it looks back at past records, so it cannot prove cause and effect. Other factors could influence the results.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 70,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Surgical patients at Beth Israel Deaconess Medical Center between September 2016 and January 2024
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients * Non-urinary system surgery * General anesthesia * Use of rocuronium or vecuronium for neuromuscular blockade * Neuromuscular blockade reversal with sugammadex or neostigmine (with atropine and/or glycopyrrolate) * Postoperative admission to the post-anesthesia care unit (PACU) Exclusion Criteria: * American Society of Anesthesiologists (ASA) physical status ≥ V * Emergency reversal with sugammadex (≥ 16 mg/kg of sugammadex) * Presence of foley or suprapubic catheter before or after the procedure * Prior history of bladder resection surgery * Observations with missing data for pre-specified confounding variables
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215, United States
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