Heart valve mystery: scientists hunt for genetic clues in 1,000 patients

NCT ID NCT04149600

Ongoing Knowledge-focused Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have no prior valve replacement or certain heart conditions.

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Conditions

The condition(s) this trial relates to.

aneurysm or dilatation of ascending aorta aortic aneurysm aortic disorder aortic valve calcification Aortic Valve Disease aortic valve disorder aortic valve insufficiency aortic valve stenosis Aortic Valve, Calcification of

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC ANEURYSM AORTIC DISEASES AORTIC VALVE CALCIFICATION AORTIC VALVE CUSP ABNORMALITY AORTIC VALVE DISEASE AORTIC VALVE DISEASE MIXED AORTIC VALVE INSUFFICIENCY CALCIFIC AORTIC STENOSIS CALCIFIC AORTIC STENOSIS - BICUSPID VALVE

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

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