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Could a heart pill delay valve replacement?

NCT ID NCT07715279

Not yet recruiting Disease control Sponsor: West China Hospital Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests whether the drug vericiguat can slow the buildup of calcium on the aortic valve in people with mild-to-moderate aortic valve stenosis. Participants take vericiguat or a placebo daily for 24 months, with regular heart scans to track valve calcium and function. The goal is to see if the drug can delay the need for valve replacement surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
vericiguat, an oral soluble guanylate cyclase stimulator
What this could lead to
If it works, this could lead to the first drug therapy to slow aortic valve disease, potentially delaying or avoiding the need for valve replacement surgery.
What could go wrong
This is a Phase 2 trial with 238 participants, so results are preliminary. The drug may not slow disease progression, and side effects like low blood pressure are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aortic valve calcification Aortic Valve Disease aortic valve disorder aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE DISEASES AORTIC VALVE STENOSIS CALCIFIC AORTIC VALVE DISEASE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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