West China Hospital

This early-phase trial tests a new mRNA vaccine called PAN-NeoVax, designed by artificial intelligence to target multiple cancer types. The vaccine is injected directly into tumors in 9 patients with advanced solid cancers who have run out of standard options. The main goal is to…

This early-phase trial is testing a new RNA vaccine called IMP3-saRNA (YMN-136) in 9 people with advanced non-small cell lung cancer who have run out of standard options. The vaccine aims to train the immune system to attack cancer cells that carry a specific marker (IMP3). The m…

This early-phase trial is testing a new vaccine made from genetically modified tumor cells in 9 adults with advanced pMMR colorectal cancer who have run out of standard options. The vaccine is given as a series of injections to see if it is safe and can stimulate the immune syste…

This study tests whether adding evolocumab, a cholesterol-lowering drug, to standard care can slow or stop plaque buildup in heart arteries after a heart attack. About 233 adults aged 40-75 who recently had a heart attack or unstable angina will receive either evolocumab plus sta…

This early-phase trial is testing a combination of three treatments for people with advanced biliary tract cancer that cannot be surgically removed. The approach delivers chemotherapy directly to the liver, along with an immunotherapy drug and a targeted therapy pill. The study a…

This early-stage study tests a new type of cancer vaccine made from irradiated tumor and nearby cells. It aims to see if the vaccine is safe and can help the immune system fight advanced solid tumors like osteosarcoma, pancreatic cancer, and others. About 54 people will take part…

This early-phase trial is testing a new approach for people with head and neck cancer that has returned or spread after standard chemotherapy. The treatment combines a gene therapy injection (EDS01) given directly into a tumor with an immunotherapy drug (toripalimab) given throug…

This early-phase study tests whether spending time in a cool room (around 18°C for 12 hours a day) can make standard immunotherapy drugs work better for people with solid tumors. Twenty-four adults with various solid cancers will receive cold exposure alongside their usual PD-1/P…

This study tests a mix of chemotherapy (NALIRIFOX), an immunotherapy drug (adebrelimab), and a special type of radiation (PULSAR) as a first treatment for people with advanced pancreatic cancer that cannot be removed by surgery. The goal is to see if this combination is safe and …

This study tests whether giving two drugs (lucanoximab and tagolimab) before surgery can shrink tumors in people with head and neck cancer. Thirty adults with resectable cancer will receive the drugs intravenously every two weeks for two cycles, then undergo surgery. Researchers …

This early-phase trial is testing whether a nasal spray vaccine (WSK-IM05) combined with an immunotherapy drug (tislelizumab) can safely shrink HPV-positive throat tumors before surgery. Nine adults with newly diagnosed, resectable HPV-positive oropharyngeal cancer will receive t…

This phase 2 trial tests a new approach for patients with resectable head and neck squamous cell carcinoma. It combines an engineered mitochondrial vaccine (IMP3-Mito) with an immune checkpoint inhibitor (PD-1 inhibitor) given before and after surgery. The goal is to improve the …

This early-stage trial tests whether injecting specially reprogrammed immune cell particles (exosomes) directly into tumors is safe for people with advanced solid tumors who have run out of standard options. Nine adults aged 18-65 will receive four injections over eight weeks. Th…

This study tests whether injecting a PD-1 inhibitor (tislelizumab or pembrolizumab) plus pemetrexed directly into the spinal fluid can help people with non-small cell lung cancer that has spread to the lining of the brain (leptomeningeal metastases). The trial will enroll 17 adul…

This early-stage trial tests whether injecting gold nanoparticles into tumors, followed by radiation and an immunotherapy drug, is safe for people with advanced melanoma. Only 6 participants will be enrolled. The goal is to check for side effects, not to see if the treatment work…

This early-stage trial is testing whether giving a drug called chidamide along with a second round of radiation is safe for people whose head and neck cancer has returned after previous radiation. Only 6 participants will be enrolled to find the best dose and check for side effec…

This early study tests a PD-1 mRNA vaccine in 9 adults with advanced liver cancer that has not responded to standard treatments. The vaccine is given as weekly shots for four weeks, then a fifth shot a month later. The main goal is to check safety, but researchers will also see i…

This early-stage trial tests a new mRNA-based drug called IL-22BP in 6 adults with advanced solid tumors that have not responded to standard treatments. The drug is injected directly into tumors to see if it is safe and can shrink cancer. The study focuses on safety and tumor res…

This study tests whether a team of specialists—including surgeons, oncologists, and geriatricians—can create better treatment plans for elderly lung cancer patients. 2,000 people aged 60-90 will receive personalized care based on their overall health and cancer type. The goal is …

This early-phase trial is testing whether a new drug called GV20-0251, combined with the immunotherapy sintilimab, is safe and can shrink tumors before surgery in people with head and neck cancer. Nine adults with advanced but removable tumors will receive two cycles of the drug …

This early-stage trial is testing an engineered mitochondrial vaccine in 12 people with advanced solid tumors who cannot have standard treatments. The vaccine is given as a series of shots to see if it is safe and can help control the cancer. The study focuses on safety first, wi…

This study tests a combination of internal radiation (Y90-SIRT) with three drugs (nivolumab, ipilimumab, and lenvatinib) in 33 people with liver cancer that cannot be surgically removed. The goal is to see if this powerful mix is safe and can shrink tumors or extend survival. It …

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system's ability to fight solid tumors like colorectal cancer. About 25 adults with solid tumors will follow this diet to see if it is safe and helps with t…

This study looks at how well different starting doses of the oral drug propranolol heal ulcers in infantile hemangioma (a type of birthmark). About 40 children with ulcerated hemangiomas will receive either a standard or higher initial dose. The main goal is to see which dose lea…

This early-phase trial is testing a new drug called DCSZ11 alongside standard chemotherapy or immunotherapy in 9 people with advanced or metastatic solid tumors, including head and neck cancer. The main goal is to see if the combination is safe and whether it can shrink tumors. B…

This study tests a new first-line treatment for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that cannot be removed by surgery. The treatment combines chemotherapy directly into the liver artery (HAIC) with two drugs: durvalumab (an immunothera…

This study tests two ways of injecting a dye (ICG) during laparoscopic liver surgery for people with liver cancer. The dye helps surgeons see tumor edges more clearly. Researchers want to know if injecting the dye into an artery works better than the usual method of injecting it …

This study tests whether adding targeted radiation (SBRT) to standard chemotherapy and immunotherapy can improve outcomes for people with early-stage triple-negative breast cancer (TNBC). TNBC is harder to treat than other breast cancers, and this combination aims to boost the im…

This early-phase trial tests a single injection of JWK010 gene therapy in 18 children aged 5 to 12 with oculocutaneous albinism type 1 (OCA1). OCA1 is caused by a gene change that prevents the body from making pigment, leading to vision problems and light sensitivity. The therapy…

This study is testing whether giving a shorter course of radiation (hypofractionated radiotherapy) along with immunotherapy (serplulimab) and chemotherapy before surgery can safely improve outcomes for people with gastroesophageal junction cancer. The trial will enroll 84 partici…

This study tests a new dye that makes liver cancer cells glow during surgery, helping doctors see exactly where the tumor is. About 30 adults with early-stage liver cancer will get the dye before their operation. The goal is to remove the cancer more completely and reduce the cha…

This study tests a combination of two drugs, afatinib and palbociclib, in people with advanced esophageal cancer that has come back or spread after prior treatment. The goal is to find a safe dose and see if the combo can shrink tumors. About 45 adults aged 18 to 75 with a specif…

This study is testing whether people with early- or intermediate-stage low rectal cancer can safely avoid major surgery if their tumor responds well to chemotherapy and radiation. Instead of removing the rectum, doctors will closely monitor patients using a "watch-and-wait" appro…

This study tests a new approach for people with advanced gastroesophageal junction cancer that cannot be removed with surgery right away. The treatment combines targeted radiation, immunotherapy, and chemotherapy to shrink the tumor enough for surgery. The goal is to see if this …

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety in a small group of 10 patients. It is not a cure, but …

This study tests a new imaging tool that uses folic acid and carbon dots to make liver cancer cells glow. After surgery, the removed liver tissue is treated with these dots and scanned with a special camera. The goal is to see if this method can find cancer edges and tiny spots b…

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This early-stage study tests whether a protein called CFH, delivered through tiny ice microneedles, can prevent skin scarring caused by radiation therapy. Nine adults with head and neck cancer who will receive radiation after surgery are being enrolled. The main goals are to chec…

This study tests a new cream made from amino acids to prevent skin damage caused by radiation therapy in people with head and neck cancer. About 40 participants will use the cream during their radiation treatment. The goal is to see if it reduces skin redness, pain, and treatment…

This study tests a liquid made from cockroach extract (Meilian Fuxin) to prevent severe skin damage in head and neck cancer patients receiving radiation therapy. About 60 participants will apply the solution to their skin during treatment. The goal is to see if it reduces the ris…

This trial tests a new anti-fog suction device that keeps the camera lens clear during nose-to-pituitary tumor surgery. Twenty adults with pituitary or craniopharyngioma tumors will either get the device or the usual water-squirt method. The goal is to see if the device reduces f…

This Phase 3 trial tests a web-based app that lets cancer patients report their pain and symptoms to doctors in real time. The goal is to improve pain management and quality of life for 100 participants, especially those in rural areas with limited medical resources. The app moni…

This study tests a new cream made from Prussian blue nanoparticles, combined with a special light therapy, to heal severe (grade III) radiation skin burns in head and neck cancer patients. The cream works by mopping up harmful molecules and, when activated by light, produces gent…

This study tests a nurse-led program that helps head and neck cancer patients manage symptoms early during radiation therapy. The goal is to see if this approach reduces the number of patients who need to pause treatment. About 170 adults with head and neck cancer will take part,…

This study tests a traditional Chinese herbal oral solution and mouthwash to see if they can shorten the time head and neck cancer patients suffer from severe mouth sores caused by radiation therapy. About 128 adults aged 18-65 with non-metastatic head and neck cancers will recei…

This phase 2 trial tests whether a traditional Chinese medicine oral liquid and mouthwash can prevent or reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 118 adults aged 18-65 will receive either the herbal treatment or a placebo along…

This study investigates whether the emotional distress of parents—such as depression, anxiety, or trauma—affects how well children with recurrent medulloblastoma follow their treatment plans. Researchers will follow 450 parent-child pairs across four hospitals, measuring parental…

This study follows 1,200 people in China with atrial fibrillation who are getting a new type of procedure called pulsed field ablation. Researchers want to see if early heart rhythm problems after the procedure can predict if the condition will come back later. Participants will …

This study looks back at the records of 2,000 adults who had liver surgery with their gallbladder left in place. Researchers want to know if a technique called the Pringle maneuver, which temporarily stops blood flow to the liver during surgery, increases the chance of developing…

This study will follow 459 adults who have been in the ICU for 8 days or more and have serious conditions like organ failure or long-term breathing support. Researchers want to find out how many patients die within one year and what factors lead to worse outcomes. The goal is to …

This study follows 300 critically ill children with sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term challenges these chil…

This study tests whether verbal, touch, and movement cues can help people wake up more quickly and smoothly from general anesthesia. Researchers will enroll 205 adults having laparoscopic abdominal surgery. They will measure time to eye opening and brain activity changes. The goa…

This study looks at 1,300 people with coronary artery disease who have a high risk of bleeding after getting a heart stent. Researchers will use artificial intelligence to analyze which blood-thinning drugs and treatment lengths work best to prevent serious bleeding and heart att…