West China Hospital

This early-stage trial tests a new type of vaccine made from engineered mitochondria, designed to help the immune system attack cancer cells. It is for people with advanced solid tumors who have no other standard treatment options. The main goal is to check safety, but researcher…

This early-stage trial tests a new vaccine called IMP3-saRNA (YMN-136) for people with advanced non-small cell lung cancer who have run out of standard options. The vaccine uses self-amplifying RNA to train the immune system to attack cancer cells. Only 9 participants will be enr…

This early-phase study tests a new mRNA vaccine, designed by artificial intelligence, in 9 people with advanced solid tumors that have not responded to standard treatments. The vaccine is injected directly into tumors to teach the immune system to attack cancer cells. The main go…

This early-phase trial tests a single injection of JWK010 gene therapy in 18 children aged 5 to 12 with oculocutaneous albinism type 1 (OCA1), a condition causing little to no pigment in the eyes, skin, and hair. The therapy is designed to help eye cells produce the missing pigme…

This early-phase study tests the safety of a new treatment made from immune cells (macrophages) that are reprogrammed to fight cancer. The treatment is injected directly into tumors in adults aged 18-65 with advanced solid tumors who have no other options. The goal is to see if i…

This early-stage trial tests a personalized vaccine made from a patient's own tumor cells, modified to boost the immune system's attack on advanced colorectal cancer that hasn't responded to standard treatments. About 9 adults will receive several vaccine injections over months, …

This early-phase study tests a new drug called DCSZ11 alongside standard treatments in 9 adults with advanced or metastatic solid tumors, including head and neck cancer. The goal is to see if the combination is safe and helps shrink or control tumors. Participants must have stand…

This study looks at two ways to use a special dye during liver cancer surgery to help surgeons see and remove tumors more precisely. About 200 adults with liver cancer will take part. The goal is to see which dye method leads to fewer cancer returns and better recovery.

This study tests a four-part treatment for people with advanced liver cancer that cannot be removed by surgery. It combines internal radiation (Y90) with three drugs (nivolumab, ipilimumab, lenvatinib) to shrink tumors and extend life. The trial enrolls 33 adults and focuses on s…

This study is for people with operable head and neck squamous cell carcinoma. It compares two treatment approaches given before surgery: one combines low-dose radiotherapy with targeted therapy and immunotherapy, the other uses only targeted therapy and immunotherapy. The goal is…

This study tests a new dye that makes liver tumors glow under special cameras during surgery. About 30 adults with early-stage liver cancer will get the dye injected before their operation. The goal is to help surgeons see exactly where the cancer is so they can remove it more pr…

This early-phase study tests whether giving a second round of radiation together with a drug called chidamide is safe for people whose head and neck cancer has come back after previous radiation. Only 6 participants will be enrolled to find the best dose and check for side effect…

This study tests whether combining two drugs, afatinib and palbociclib, can help people with advanced esophageal cancer that has come back or spread after prior treatment. About 45 adults aged 18 to 75 will take part. The goal is to find a safe dose and see if the combination shr…

This early-stage trial tests a new drug called GV20-0251 in people with advanced solid tumors that no longer respond to standard treatments. The main goal is to check the drug's safety. About 10 adults with cancers like liver, lung, or skin cancer will take part. This is not a cu…

This study looks at whether different starting doses of the oral medication propranolol can help heal ulcers (sores) that form on infantile hemangiomas, a common type of birthmark. About 40 children with these ulcers will be treated and followed to see how quickly the sores heal …

This early-phase study tests a new type of cancer vaccine made from irradiated tumor and supporting cells. The goal is to see if it is safe and can help the immune system fight advanced solid tumors like osteosarcoma, pancreatic cancer, and others. About 54 participants will rece…

This study is for people with advanced gastroesophageal junction cancer that cannot be removed with surgery. It tests a combination of targeted radiation, immunotherapy, and chemotherapy to shrink the tumor enough so that surgery becomes possible. About 88 adults will take part t…

This early-stage trial tests a new mRNA vaccine designed to help the immune system fight advanced liver cancer. It is for people whose cancer has not responded to standard treatments. The main goal is to check safety and see if the vaccine can control the disease.

This early-phase study tests whether a new gold nanoparticle treatment (Au-TMP) is safe when injected into tumors, followed by radiation and an immunotherapy drug (Toripalimab). It involves 6 adults with advanced melanoma that cannot be surgically removed. The main goal is to che…

This study tests a new first-line treatment for people with advanced bile duct cancer that cannot be removed by surgery. The treatment combines chemotherapy delivered directly to the liver (HAIC) with two drugs: durvalumab (an immunotherapy) and lenvatinib (a targeted therapy). T…

This study is for people with early- or intermediate-risk low rectal cancer. It tests whether patients who respond well to chemotherapy and radiation can safely avoid surgery and instead be closely monitored (watch-and-wait). The goal is to preserve the rectum and improve quality…

This study tests whether adding targeted radiation (SBRT) to standard chemotherapy and immunotherapy can improve outcomes for people with early-stage triple-negative breast cancer (TNBC). TNBC is a hard-to-treat type of breast cancer with fewer treatment options. The trial will e…

This early-phase trial tests whether combining two drugs (GV20-0251 and sintilimab) before surgery is safe and can shrink tumors in adults with advanced head and neck cancer. Nine participants will receive two cycles of the drug combo, then undergo surgery. The study focuses on s…

This study is for people with a certain type of cancer where the stomach meets the esophagus. It tests if giving a special kind of radiation together with immunotherapy and chemotherapy before surgery is safe and works better. About 84 adults with advanced but removable cancer wi…

This early-stage trial is testing a new drug called IL-22BP in about 6 adults with advanced solid tumors that have not responded to at least two prior treatments. The main goal is to check the drug's safety and find the right dose, while also seeing if it can shrink tumors. Parti…

This early-stage study is testing the safety and effectiveness of a new drug combination (HRS-4642 plus nimotuzumab) for people with advanced pancreatic cancer that has returned or spread. The study will enroll about 20 patients to find the right dose and see if the treatment can…

This study tests a new imaging tool that uses folic acid and tiny carbon dots to make liver cancer cells glow under a special camera. After surgery to remove liver cancer, the removed tissue is treated with these dots and scanned to see if the glow can help find cancer edges and …

This study tests a special cream made from amino acids to prevent skin damage caused by radiation therapy in people with head and neck cancer. The cream aims to reduce redness, pain, and peeling of the skin. About 40 participants will be randomly assigned to receive the cream or …

This early-stage trial tests whether a protein called CFH, delivered through ice microneedles, can prevent skin hardening (fibrosis) caused by radiation therapy. Nine adults with head and neck cancer who will receive radiation after surgery will get the patches twice a week for f…

This study tests a liquid made from cockroach extract (Meilian Fuxin Liquid) to prevent severe skin reactions in head and neck cancer patients receiving radiation therapy. About 60 participants will apply the solution to their skin during treatment. The goal is to see if it reduc…

This study tests a web-based platform that lets cancer patients report their pain levels and medication use to their doctors in real time. The goal is to improve pain management and quality of life, especially for patients in rural areas with limited access to healthcare. About 1…

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system in people with solid tumors like colorectal cancer. About 25 participants will follow this diet to see if it is safe and helps with treatment respons…

This study tests a nurse-led plan to manage symptoms early in head and neck cancer patients getting radiation. The goal is to see if it reduces treatment breaks. About 170 adults will take part, comparing the new approach to standard care.

This study tests whether traditional Chinese medicine oral liquids and mouthwashes can reduce severe mouth sores caused by radiation therapy in head and neck cancer patients. About 118 adults aged 18-65 who need radiation will be randomly assigned to receive the Chinese medicine …

This early study tests a new treatment for severe radiation burns (grade III) in head and neck cancer patients. The treatment combines a special nanozyme (Prussian blue-based) with near-infrared heat therapy to help the burns heal faster. Only 5 people will take part, and the mai…

This study tests a traditional Chinese herbal solution and mouthwash to see if they can shorten the time patients suffer from severe mouth sores caused by radiation therapy. About 128 adults with head and neck cancer who are getting radiation will take part. The goal is to reduce…

This study tests a new method called the Huaxi Tunnel Technique to protect the nerve that controls the voice box during thyroid surgery. The technique uses a fluid injection to create a safe tunnel around the nerve, which may reduce bleeding and nerve damage. Researchers will com…

This study reviews medical records of 2,000 adults who had liver surgery with their gallbladder left in place. Researchers want to see if temporarily clamping the liver's blood supply (called the Pringle maneuver) makes patients more likely to develop gallstones, inflammation, or…

This study tests whether gentle talking, touching, or moving patients helps them wake up more quickly and smoothly from general anesthesia. About 205 adults having laparoscopic abdominal surgery will receive these non-drug stimulations as they emerge from anesthesia. The goal is …

This study follows 1,200 people with atrial fibrillation (AF) in China who are getting a new type of heart procedure called pulsed field ablation. The goal is to see if early heart rhythm issues after the procedure can predict long-term problems. Participants will have regular ch…

This study looks at 1300 heart patients who had a stent placed (PCI) and are at high risk for bleeding. Researchers will use artificial intelligence to find which blood thinner medicines work best and for how long to prevent heart attacks and strokes while avoiding dangerous blee…

This study is testing whether a team of different specialists (like surgeons, cancer doctors, and geriatricians) can create better, personalized treatment plans for older adults (ages 60-90) with lung cancer. The goal is to see if this team approach helps people live longer witho…

This study follows 300 critically ill children who had sepsis for five years after they leave the hospital. Researchers want to see how sepsis affects their growth, brain development, survival, and quality of life. The goal is to better understand the long-term impact of this ser…

This study follows 459 adults who have been in the ICU for 8 days or more with serious conditions like organ failure or long-term breathing support. Researchers will call participants over the next year to see how they are doing and what factors lead to poor outcomes. The goal is…