Nasal spray vaccine plus immunotherapy shows promise in early throat cancer trial
NCT ID NCT07565740
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether a nasal spray vaccine (WSK-IM05) combined with an immunotherapy drug (tislelizumab) can safely shrink HPV-positive throat tumors before surgery. Nine adults with newly diagnosed, resectable HPV-positive oropharyngeal cancer will receive two cycles of the combination, then undergo surgery followed by standard care. The main goals are to check safety and see how well the tumors respond.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- WSK-IM05 (nasal spray vaccine) and tislelizumab (immunotherapy drug)
- What this could lead to
- If it works, this could point toward a less invasive way to treat HPV-positive throat cancer by shrinking tumors before surgery and possibly reducing the need for harsh treatments afterward.
- What could go wrong
- This is a very early, small Phase 1 trial with only 9 participants, so results may not apply broadly. The combination may cause significant side effects, and the vaccine plus immunotherapy might not shrink tumors as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, 610000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood test may tailor throat cancer treatment, sparing patients from harsh side effects
- Robotic surgery may spare throat cancer patients from chemo and radiation
- Vaccine trains immune system to fight HPV-Positive head and neck tumors
- New Vaccine-Drug combo aims to tame HPV throat cancer with less radiation
- Can less radiation be just as good for HPV throat cancer?
- New combo aims to tame HPV throat cancer with fewer side effects