Experimental combo aims to tackle returning head and neck cancer
NCT ID NCT07545967
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing whether giving a drug called chidamide along with a second round of radiation is safe for people whose head and neck cancer has returned after previous radiation. Only 6 participants will be enrolled to find the best dose and check for side effects. The goal is to see if this combination can help control the cancer without causing too many severe problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Chidamide (a type of drug called a histone deacetylase inhibitor, taken orally)
- What this could lead to
- If successful, this could point toward a new treatment option for patients whose head and neck cancer has come back after radiation therapy.
- What could go wrong
- This is a very early, small Phase 1 trial with only 6 participants, so results may not apply broadly. The combination of re-irradiation and chidamide may cause serious side effects, and it is not yet known if it will effectively control the cancer.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
West China Hospital of Sichuan University
RECRUITINGChengdu, Sichuan, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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