New scan spots hidden cancer spread before surgery
NCT ID NCT06794372
First seen May 13, 2026 · Last updated Jun 23, 2026 · Updated 6 times
Summary
This Phase 2 trial tests whether a special PET/CT scan using [68Ga]Ga-FAPI-46 can detect early lymph node metastases in people with head and neck squamous cell carcinoma. The scan targets cancer-associated fibroblasts, which help create a welcoming environment for cancer to spread. Researchers will compare the scan results with standard imaging and with the actual lymph nodes removed during surgery to see if it can identify at-risk nodes before they become full metastases.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre hospitalier universitaire vaudois
RECRUITINGLausanne, Canton of Vaud, 1011, Switzerland
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
[68Ga]Ga-FAPI-46 (a radioactive tracer for PET/CT imaging)
What this could lead to
If successful, this imaging method could help doctors detect lymph node metastases earlier and more accurately, leading to better treatment decisions for head and neck cancer patients.
What could go wrong
This is a small early-phase trial with only 20 participants, so results may not apply to everyone. The imaging technique is still experimental and may not prove better than current methods.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.