West China Hospital

This early-phase trial tests an mRNA vaccine that targets the Epstein-Barr virus (EBV) in people with HIV-related lymphoma. EBV is linked to many of these cancers, and the vaccine aims to help the immune system fight the tumor. The study will enroll 6 adults to check safety and s…

This study tests a treatment that combines a modified virus (H101) with a procedure called TACE (chemoembolization) for people with recurrent or metastatic head and neck cancer that hasn't responded to at least two prior treatments. The goal is to kill tumor cells and activate th…

This phase 2 trial tests whether giving camrelizumab (an immunotherapy) and palbociclib (a targeted therapy) before surgery can safely shrink tumors in people with esophageal squamous cell carcinoma that can be removed. About 41 adults aged 18-75 with resectable cancer will recei…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that have not responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the d…

This study tests whether giving a new drug (becotatug vedotin) alone or with immunotherapy before surgery can shrink tumors in people with advanced head and neck cancer. About 120 adults who have not had prior treatment will receive the drugs before their planned surgery. The goa…

This early-stage trial tests whether combining two drugs, JDB153 and serplulimab, can shrink tumors or slow disease in people with advanced pancreatic cancer that has stopped responding to standard therapies. About 10 participants will receive the combination to check for safety …

This early-phase trial tests a new drug that helps the immune system recognize and attack cancer cells by blocking a 'don't eat me' signal. It is for people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and find the ri…

This study tests whether a combination of two drugs (vedotin-tislelizumab and toripalimab) can shrink tumors in people with advanced bile duct cancer that has not responded to previous treatments. About 44 adults aged 18-70 with a specific protein (EGFR) on their cancer cells wil…

This study tests whether giving two drugs (lucanoximab and tagolimab) before surgery can shrink head and neck tumors in 30 adults. Participants receive the drugs intravenously every two weeks for two cycles, then undergo surgery. The main goal is to see how many patients have mos…

This early-phase study tests whether spending time in a cool room (around 18°C) alongside standard immunotherapy is safe and doable for people with solid tumors. About 24 participants will undergo cold exposure for several hours a day during their treatment cycles. The goal is to…

This study tests a new treatment for head and neck cancer that combines an experimental vaccine with immunotherapy. The vaccine is designed to train the immune system to attack cancer cells, while the immunotherapy helps remove the brakes on immune cells. The treatment is given b…

This study tests whether surgeons can safely remove liver parasites (hepatic echinococcosis) using a 5G-connected robot from hundreds of miles away. Ten patients in Lhasa, Tibet will have surgery performed by expert doctors in Chengdu using the Toumai™ robotic system. The goal is…

This study aims to find the safest way to stop sirolimus medication in children with kaposiform hemangioendothelioma, a rare blood vessel tumor. Researchers will compare three different tapering schedules in 120 patients who have already responded well to treatment. The main goal…

This study tests a new handheld scanner that helps surgeons see cancer cells at the edges of removed breast tissue during surgery. Current methods can miss some cancer, leading to repeat operations. The scanner gives results in under five minutes. About 165 women with early-stage…

This study tests whether a superoxide dismutase (SOD) spray can prevent severe skin reactions (radiation dermatitis) in 140 head and neck cancer patients receiving high-dose radiation. The spray aims to neutralize free radicals caused by radiation. Researchers will check patients…

This study tests whether mecobalamin, a form of vitamin B12, can speed up healing of the nerve that controls the vocal cords after thyroid surgery. About 528 adults having open thyroid surgery will receive either mecobalamin or a placebo for several weeks. The goal is to see if t…

This study looks at whether keeping the head flat or slightly raised (30°) for the first 24 hours after severe stroke treatment helps patients recover better. About 1,500 adults with severe ischemic stroke will be randomly assigned to one of two head positions. The goal is to fin…

This study tests a new system that uses wearable devices and a smartphone app to help people with non-small cell lung cancer recover after chest surgery. About 126 participants will either get standard care or use the wearable system, which tracks their activity and guides home e…

This study aims to develop an AI model that analyzes neck ultrasound images and reports to predict if papillary thyroid cancer has spread to lymph nodes. Researchers will enroll 3,200 patients and compare the AI's predictions with standard pathology results. The goal is to improv…