West China Hospital

This early-phase study tests a new vaccine called YMN-136 in 9 people with advanced colorectal cancer that has spread to the liver and has not responded to three prior treatments. The main goals are to check the vaccine's safety and find the best dose. Researchers will also watch…

This trial tests a personalized mRNA vaccine called NeoOVIV in people with stage II or III ovarian cancer who have had surgery. The vaccine is designed to teach the immune system to recognize and attack cancer cells. Participants receive the vaccine alongside standard chemotherap…

This study looks at whether stopping propranolol suddenly or slowly is better for preventing hemangioma regrowth in infants. About 110 children who have taken propranolol for at least 6 months will be randomly assigned to either stop immediately or taper over 4 weeks. The goal is…

This study tests whether adding precisely targeted radiation to standard hormone therapy helps men with metastatic hormone-sensitive prostate cancer. All participants first receive six months of darolutamide plus androgen deprivation therapy. Those whose cancer has not progressed…

This study will compare a newer, less invasive endoscopic breast reconstruction method (direct-to-implant) with traditional flap surgery (using tissue from the abdomen) in 588 women who had a mastectomy at least one year ago. The goal is to see if the endoscopic approach leads to…

This early-phase trial is testing a new mRNA-based drug called YMN-A02 in 10 people with advanced colorectal cancer that has spread to the liver and has not responded to standard treatments. The drug is designed to help the immune system attack the cancer by producing a CTLA-4 an…

This study tests whether a combination of disitamab vedotin (a targeted drug) and toripalimab (an immunotherapy) works better than standard chemotherapy plus immunotherapy for people with HER2-positive muscle-invasive bladder cancer. About 240 participants will receive treatment …

This early-stage trial tests a new drug (non-cationic peptide-CD47 siRNA) in about 9 people with advanced solid tumors that have not responded to other treatments. The drug works by blocking a 'don't eat me' signal on cancer cells, helping the immune system recognize and attack t…

This study compares a new procedure using a special stent (underdilated VCX-TIPS) with standard treatment (endoscopic banding plus beta-blockers) to prevent variceal rebleeding in people with cirrhosis. The new approach uses a smaller balloon to expand the stent, aiming to lower …

This early-phase study tests a new mRNA-based treatment for people with advanced solid tumors that have not responded to standard therapies. The treatment aims to control tumor growth by delivering a specific protein (IL-22BP) using a peptide carrier. The main goals are to check …

This early-phase study tests a new mRNA medicine (NCP-IL-22BP mRNA) in 9 people with advanced solid tumors that have not responded to standard treatments. The medicine is injected directly into tumors to help the body fight cancer. The main goal is to check safety and find the ri…

This early-stage trial tests a new RNA-based drug called YMN-A02 in 10 people with advanced liver cancer that has stopped responding to standard treatments. The drug is designed to boost the immune system by blocking two cancer defenses at once. The main goal is to check safety a…

This early-phase study tests whether injecting tiny tantalum particles directly into a recurrent soft tissue sarcoma tumor, followed by radiation, is safe and tolerable. Nine adults with a specific type of sarcoma that has come back after standard treatment will receive one of th…

This early-phase study tests an experimental mRNA vaccine that targets the Epstein-Barr virus (EBV) in people with HIV who have lymphoma. The vaccine aims to help the immune system fight tumors linked to EBV. The study will enroll 6 adults and primarily check for safety and signs…

This early-stage trial will test whether surgeons in Chengdu can safely remove liver parasites from 10 patients in Lhasa (3,650m altitude) using a 5G-connected robot. The goal is to see if the remote surgery can be completed without major issues. If it works, it could bring exper…

This study looks at a new treatment for people with a specific type of advanced stomach cancer (HER2-positive) that has stopped responding to standard therapies. It combines a targeted drug (disitamab vedotin) with immunotherapy and a special type of radiation. The goal is to see…

This study tests a combination of two drugs (vebecotototo and putli monoclonal antibodies) in 44 people with advanced bile duct cancer that has a specific marker (EGFR) and has not responded to prior treatment. The goal is to see if the combination can shrink tumors and control t…

This study tests a new device designed to repair remaining tears in the aorta after initial emergency surgery for a serious condition called type A aortic dissection. About 198 adults who still have a tear in their aorta after their first surgery will be randomly assigned to eith…

This Phase 2 trial tests a combination of two drugs—Becotatug vedotin (a targeted therapy) and Pucotenlimab (an immunotherapy)—as a first treatment for people whose nasopharyngeal cancer has come back or spread. The study will enroll 30 adults and measure how long the cancer stay…

This study looks at 100 liver cancer patients whose tumors shrank or disappeared after initial therapy. It compares two follow-up options: surgery to remove any remaining cancer, or continuing medication (maintenance therapy). The goal is to see which approach better prevents the…

This study tests a combination of a modified virus (H101) and a targeted chemotherapy procedure (TACE) in 20 adults with head and neck cancer that has returned or spread after at least two standard treatments. The goal is to shrink tumors and boost the immune system while limitin…

This early-phase study tests a new mRNA drug that targets two proteins (CD19 and BCMA) on immune cells. The goal is to clear the faulty B cells and plasma cells that attack the body in autoimmune diseases. 27 adults aged 18-70 with relapsed or hard-to-treat autoimmune diseases wi…

This phase 2 trial tests a drug called becotatug vedotin, given alone or with immune-boosting drugs (penpulimab or ivonescimab), before surgery for head and neck cancer. The goal is to see if these treatments can shrink tumors or even make them disappear completely. The study inv…

This early-stage trial tests a therapeutic mRNA vaccine that targets a protein called FAP found on cancer-supporting cells. The goal is to help the immune system attack the tumor's defenses. Ten adults with advanced solid tumors (like lung, colorectal, or pancreatic cancer) who h…

This early-phase study tests a new drug called WGb-0301 for people with autoimmune diseases (like lupus or autoimmune hepatitis) that haven't responded to standard treatments. The drug uses mRNA technology to target and clear certain immune cells (B cells) that are causing the di…

This Phase III trial tests whether adding targeted radiation and an immunotherapy drug (serplulimab) to standard chemotherapy can help people with advanced pancreatic cancer live longer. About 198 participants who have not had prior treatment will be randomly assigned to receive …

This early-phase study tests whether a diet very low in vitamin B6 can make immunotherapy work better for people with solid tumors. About 20 adults aged 18-80 will follow this special diet for 6 weeks while continuing their regular immunotherapy. The main goal is to check if the …

This study tests whether adding a PCSK9 inhibitor (a strong cholesterol-lowering drug) to standard statin therapy can stabilize fatty plaques in the arteries of people who recently had a heart attack. About 212 participants will receive either the drug combination or standard car…

This phase 3 trial tests whether combining desiccated thyroid extract (DTE) with standard levothyroxine can help intermediate-to-high risk thyroid cancer patients reach their TSH suppression targets faster and more safely after surgery. Many patients on levothyroxine alone strugg…

This study tests whether giving two drugs—camrelizumab (an immunotherapy) and palbociclib (a targeted therapy)—before surgery can safely shrink tumors in people with esophageal cancer that can be removed. About 41 adults with resectable esophageal squamous cell carcinoma will rec…

This early-phase trial will test a combination of two drugs—JDB153 (taken as a pill) and serplulimab (given by IV)—in 10 people with advanced pancreatic cancer that has not responded to standard treatments. The main goals are to check safety and see if the drugs can shrink tumors…

This study looks at children with kaposiform hemangioendothelioma (KHE), a rare vascular tumor, who have been taking sirolimus. The goal is to find the best way to stop the drug without the tumor growing back. 120 participants will be randomly assigned to one of three tapering st…

This study tests a new handheld scanner that gives surgeons a real-time, close-up view of the surgical area to see if any cancer cells remain after removing a breast tumor. Current methods can take time and may miss some cancer cells, sometimes requiring a second surgery. The sca…

This study tests whether a product made from spirulina (a type of algae) can prevent severe throat pain caused by radiation therapy in people with esophageal cancer. About 70 patients will receive either the spirulina derivative or a placebo during their radiation treatments. The…

This study tests whether adding a bile acid pill (UDCA) to standard treatment can prevent a serious brain condition called hepatic encephalopathy after a liver procedure (TIPS). About 270 adults with cirrhosis will be randomly assigned to receive either UDCA plus lactulose or lac…

This study compares a new breast reconstruction method done in one surgery through a small armpit incision to the standard two-stage expander-to-implant approach. About 412 women who had a mastectomy at least a year ago will take part. The goal is to see which method has fewer co…

This study tests whether a wearable device and smartphone app can help people recover knee function at home after surgery for a discoid meniscus (a misshapen knee cartilage). Sixty participants will be randomly assigned to either in-person rehab at a clinic or remote rehab using …

This study tests whether a wearable device and digital platform can help people recover better after lung cancer surgery. About 126 patients with non-small cell lung cancer will either use the wearable system or receive standard care. The system tracks heart rate, oxygen levels, …

This phase 3 trial tests whether mecobalamin, an active form of vitamin B12, can help heal the nerve that controls the vocal cords after thyroid surgery. About 528 adults undergoing open thyroid surgery will take either mecobalamin or a placebo for three months. The goal is to se…

This study will follow 150 infants with a type of birthmark called infantile hemangioma. Some have a less active form that barely grows, while others have the typical form. Doctors will assess each baby using standard guidelines and decide whether to recommend treatment or just w…

This study looks at babies with a common type of birthmark (infantile hemangioma) on the lower back, bottom, or genital area. The goal is to find the best size cutoff for the birthmark to decide which babies should be screened for LUMBAR syndrome, a condition that can involve hid…

This study compares two common head positions—lying flat (0°) versus raising the head 30°—for the first 24 hours after a severe ischemic stroke. Researchers want to see which position leads to better recovery and fewer complications. About 1,500 adults with severe stroke will be …

This study aims to develop an AI model that analyzes neck ultrasound images and reports to predict whether thyroid cancer has spread to nearby lymph nodes. Researchers will compare the AI's predictions with actual surgical results from 3,200 patients. If successful, this tool cou…

This study will review medical records of 700 adults with severe pancreatitis and sepsis who had surgery to remove dead tissue. Researchers want to see how organ function changes over time after the operation. The goal is to better understand recovery patterns and outcomes.

This study will examine how quality of life changes after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will use a database to compare quality-of-life scores, anxiety, and depression before and after surgery. The goal is to be…