Can vitamin B12 restore your voice after thyroid surgery? new trial aims to find out
NCT ID NCT07274696
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether mecobalamin, an active form of vitamin B12, can help heal the nerve that controls the vocal cords after thyroid surgery. About 528 adults undergoing open thyroid surgery will take either mecobalamin or a placebo for three months. The goal is to see if the vitamin improves voice quality and speeds recovery, potentially reducing hoarseness and other voice problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mecobalamin (a form of vitamin B12)
What this could lead to
If it works, this could provide a simple, safe way to speed up voice recovery after thyroid surgery and reduce complications like hoarseness.
What could go wrong
This is a large phase 3 trial, but previous studies on mecobalamin for nerve recovery have been small and inconsistent. The benefit may be modest or absent.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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West China hospital of Sichuan University
Chengdu, Sichuan, 610041, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••