Can vitamin B12 restore your voice after thyroid surgery? new trial aims to find out
NCT ID NCT07274696
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether mecobalamin, an active form of vitamin B12, can help heal the nerve that controls the vocal cords after thyroid surgery. About 528 adults undergoing open thyroid surgery will take either mecobalamin or a placebo for three months. The goal is to see if the vitamin improves voice quality and speeds recovery, potentially reducing hoarseness and other voice problems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mecobalamin (a form of vitamin B12)
- What this could lead to
- If it works, this could provide a simple, safe way to speed up voice recovery after thyroid surgery and reduce complications like hoarseness.
- What could go wrong
- This is a large phase 3 trial, but previous studies on mecobalamin for nerve recovery have been small and inconsistent. The benefit may be modest or absent.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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West China hospital of Sichuan University
Chengdu, Sichuan, 610041, China
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