Triple-Drug attack on bile duct cancer shows early promise
NCT ID NCT07636798
First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 3 times
Summary
This early-phase trial is testing a combination of three treatments for people with advanced biliary tract cancer that cannot be surgically removed. The approach delivers chemotherapy directly to the liver, along with an immunotherapy drug and a targeted therapy pill. The study aims to find the safest dose and see if the combo can shrink tumors. Only 20 participants will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a combination of chemotherapy (gemcitabine and cisplatin) given directly into the liver, plus an immunotherapy drug (envafolimab) and a targeted therapy pill (lenvatinib)
- What this could lead to
- If this works, it could offer a new first-line treatment option for people with advanced biliary tract cancer that cannot be removed by surgery.
- What could go wrong
- This is a very early, small trial (only 20 people) with no comparison group, so results may not apply broadly. The drug combination can cause serious side effects like liver damage or bleeding.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Study Chair Liu Chang , West China Hospital, Chengdu, Sichuan 610041
RECRUITINGChengdu, Sichuan, 610041, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smart drug home in on Hard-to-Treat cancers?
- Can a new immunotherapy combo shrink Hard-to-Treat tumors?
- Can two targeted drugs boost chemo against a rare Bile-Duct cancer?
- New drug cocktail aims to outperform standard immunotherapy in bile duct cancer
- Liver cancer registry aims to uncover new biomarkers from thousands of patients
- Triple-Drug cocktail targets Hard-to-Treat biliary cancers