Experimental vaccine targets Hard-to-Treat colorectal cancer
NCT ID NCT07510308
First seen Jun 25, 2026 · Last updated Jul 01, 2026 · Updated 3 times
Summary
This early-phase trial is testing a new vaccine made from genetically modified tumor cells in 9 adults with advanced pMMR colorectal cancer who have run out of standard options. The vaccine is given as a series of injections to see if it is safe and can stimulate the immune system to fight the cancer. The main goal is to check for side effects, with a secondary look at whether tumors shrink.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MSH2-/- tumor cell vaccine
- What this could lead to
- If it works, this could point toward a new treatment option for advanced colorectal cancer that has not responded to standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 9 participants, so it is primarily testing safety, not effectiveness. The vaccine may not shrink tumors or improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, 610041, China
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West China Hospital, Sichuan University
RECRUITINGChengdu, Sichuan, China