Experimental combo aims to shrink head and neck tumors before surgery
NCT ID NCT07457281
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial is testing whether a new drug called GV20-0251, combined with the immunotherapy sintilimab, is safe and can shrink tumors before surgery in people with head and neck cancer. Nine adults with advanced but removable tumors will receive two cycles of the drug combo, then undergo surgery. The study focuses on safety and how well the tumors respond.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- GV20-0251 and sintilimab (a PD-1 inhibitor)
- What this could lead to
- If this early study shows the combination is safe and shrinks tumors before surgery, it could point toward a new neoadjuvant option for head and neck cancer.
- What could go wrong
- This is a very small Phase 1 trial with only 9 people, so results may not apply broadly. The main goal is safety, not effectiveness, and side effects are unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
West China Hospital, Sichuan University
RECRUITINGChengdu, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New scan spots hidden cancer spread before surgery