One dose before surgery: could vitamin B3 shield kidneys?

NCT ID NCT07739290

Not yet recruiting Prevention Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether a single high dose of nicotinamide (a form of vitamin B3) taken on the morning of heart surgery can reduce the risk of acute kidney injury afterward. The study enrolls 20 adults undergoing coronary bypass or valve surgery with a heart-lung machine who are at higher risk for kidney damage. Half receive the supplement and half receive a placebo, and researchers measure a kidney injury marker in urine to see if the supplement shows promise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nicotinamide (NAM), a form of vitamin B3, given as a single 3000 mg oral dose
What this could lead to: If this pilot succeeds, it could pave the way for a larger trial and potentially a simple, low-cost way to protect kidneys during heart surgery.
What could go wrong: This is a small pilot study focused on feasibility, not proof of effectiveness. The single dose may not be enough, and results may not generalize to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ACUTE KIDNEY INJURY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY

More trials for these conditions

Other studies related to the condition(s) this trial covers.