Can a sleep apnea machine help people with collapsing airways walk farther?

NCT ID NCT04217603

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether using a CPAP machine during a 6-minute walk test helps people with excessive central airway collapse (ECAC) walk farther and feel less breathless. ECAC is a condition where the central airways narrow or collapse during breathing, making exercise difficult. Researchers will compare CPAP to a sham device in 32 adults, measuring walking distance, breathing effort, and cough. CPAP is already FDA-approved for sleep apnea but not for ECAC.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
Continuous positive airway pressure (CPAP) device
What this could lead to
If it works, CPAP could become a non-invasive way to improve exercise capacity and reduce shortness of breath in people with excessive central airway collapse.
What could go wrong
This is a small, early-stage trial with only 32 participants. CPAP is not yet approved for this condition, and the sham comparison may show no meaningful benefit.

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Conditions

The condition(s) this trial relates to.

congenital tracheomalacia Tracheobronchomalacia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

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