Can a sleep apnea machine help people with collapsing airways walk farther?
NCT ID NCT04217603
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This study tests whether using a CPAP machine during a 6-minute walk test helps people with excessive central airway collapse (ECAC) walk farther and feel less breathless. ECAC is a condition where the central airways narrow or collapse during breathing, making exercise difficult. Researchers will compare CPAP to a sham device in 32 adults, measuring walking distance, breathing effort, and cough. CPAP is already FDA-approved for sleep apnea but not for ECAC.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- Continuous positive airway pressure (CPAP) device
- What this could lead to
- If it works, CPAP could become a non-invasive way to improve exercise capacity and reduce shortness of breath in people with excessive central airway collapse.
- What could go wrong
- This is a small, early-stage trial with only 32 participants. CPAP is not yet approved for this condition, and the sham comparison may show no meaningful benefit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
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