Congenital tracheomalacia

This study tests whether using cryopreserved aortic patches (donated tissue) can safely repair defects in the windpipe or bronchial tubes. Ten people with severe tracheal narrowing or deformities will receive this surgical patch. The main goal is to see if it reduces death and co…

This study tests a custom 3D-printed splint that holds open a child's collapsing airway. The splint is made of a material that the body absorbs over about five years. The trial includes 35 children with severe tracheobronchomalacia who need breathing support. Researchers will che…

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study tests whether using a CPAP machine during a 6-minute walk test helps people with excessive central airway collapse (ECAC) walk farther and feel less breathless. ECAC is a condition where the central airways narrow or collapse during breathing, making exercise difficult…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study collects medical information and samples from people with hearing, balance, taste, smell, voice, speech, or language disorders. Researchers aim to use this data for future studies and to find candidates for other research. Participants receive standard care, and no exp…