New study tests which breathing aid works best for heart failure patients coming off ventilators

NCT ID NCT06671015

Recruiting now Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two breathing support methods—high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV)—in heart failure patients after their breathing tube is removed. The goal is to see which method better prevents the need for re-insertion of the breathing tube or respiratory failure within 72 hours. The trial will enroll 50 high-risk patients with systolic heart failure at Yale New Haven Hospital.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) devices
What this could lead to: If it works, this could show that high-flow nasal cannula is a better or equally effective way to prevent reintubation in heart failure patients, potentially improving recovery and reducing complications.
What could go wrong: This is a small pilot study with only 50 participants, so results may not apply to all patients. The open-label design means both doctors and patients know which treatment is given, which could bias outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

respiratory failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY FAILURE SYSTOLIC HEART FAILURE

Contacts and locations

Locations

Yale New Haven Hospital (CICU or MICU)
RECRUITING

New Haven, Connecticut, 06520, United States

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