PNEUMONIA

This early-stage trial tested a new 23-valent pneumococcal polysaccharide vaccine in 144 healthy people aged 2 and older. Participants received one dose of either the experimental or a control vaccine. The study checked for side effects and measured immune response through blood …

This completed study looked at how effective the Prevnar 13 (PCV13) vaccine is at preventing pneumonia and related infections in adults with HIV. Researchers analyzed health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The g…

This study tests whether special breathing techniques called neurophysiological facilitation of respiration can improve oxygen levels and shorten hospital stays in children aged 6 months to 2 years with pneumonia. The techniques involve gentle stretches and co-contraction of the …

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This early-stage trial tested a single inhaled dose of FLAMOD, a protein that mimics a bacterial signal to activate the immune system, in 46 healthy adults. The goal was to check safety and see if it triggers a local immune response in the lungs. If it works, this approach might …

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested a drug called Auxora in 314 people with severe COVID-19 pneumonia. The goal was to see if it could help patients recover faster and reduce the need for breathing machines. Participants received either Auxora or a placebo, along with standard treatments. Results …

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce …

This study looked at whether giving children a longer course of antibiotics (amoxicillin-clavulanic acid) after hospitalization for pneumonia leads to better recovery compared to a shorter course. It involved 314 children aged 3 months to 5 years in Australia. The goal was to see…

This study tested whether using very small breaths (ultraprotective ventilation) on a breathing machine, without a heart-lung bypass machine, could improve survival and reduce time on the ventilator for COVID-19 patients with severe lung injury. About 220 adults with confirmed CO…

This study tested whether using lung ultrasound to guide how nurses position ventilated newborns can prevent pneumonia better than standard repositioning every two hours. Researchers enrolled 80 full-term infants on breathing machines. The goal was to see if personalized position…

This study tested two drugs, ruxolitinib and fostamatinib, in hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the disease from becoming severe. 185 patients were randomly assigned to receive one of the drugs or standa…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested a rapid diagnostic test (BioFire Pneumonia Panel) in 40 ICU patients on ventilators with suspected pneumonia. Half got the rapid test, half got standard care. The goal was to see if the test helps doctors give the right antibiotics sooner. Results could lead to …

This study tested whether using a low-dose CT scan or lung ultrasound is more accurate than the usual chest X-ray for diagnosing pneumonia in people over 65. About 473 older adults with suspected pneumonia in the emergency room took part. The goal was to see if better imaging cou…

This study looked at whether lung ultrasound (LUS) can accurately diagnose pneumonia in children in low-resource settings, where chest X-rays are often unavailable. Researchers compared LUS results to a 'gold standard' diagnosis based on clinical exams, imaging, and lab tests. Th…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage eight common conditions (like pneumonia, kidney stones, and pregnancy issues) without needing extra tests. Over 160 patients took part, and researchers compared …

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This completed study from France looked at health records of 2 million adults to see if having pneumonia increases the chance of later heart problems like heart attacks, strokes, or heart failure. Researchers compared people who had pneumonia with similar people who did not. The …

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This study tested whether a tool called the ARISCAT score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if the score could help …

This study looked at whether a set of care guidelines (called a pathway) could help doctors and nurses in community hospitals use the best treatments for children hospitalized with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across many hospitals. The goal…

This study tested whether electronic alerts and structured messages from an antibiotic stewardship team could reduce antibiotic use in hospitalized patients with suspected pneumonia. 107 adults were enrolled, and those with test results suggesting viral infection were randomly as…

This study aimed to find biomarkers in patients with pneumonia. Researchers enrolled 272 participants and tracked outcomes like death in the hospital and whether the pneumonia got worse. The goal was to better understand the disease, not to test a new treatment.

This study observed over 1,800 children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It aimed to track how many children were hospitalized for bronchiolitis after a new immunization became available. The study did not test any new treatmen…

This study tested three different oximeters (Masimo, Nellcor, Nonin) at various oxygen targets in 40 patients with and without COPD. The goal was to see how the choice of oximeter and target affects the amount of oxygen needed. Results could help guide safer oxygen therapy.

This study created and tested a risk score called RESPIRE to predict whether a patient's pneumonia is caused by multidrug-resistant bacteria. Researchers looked at data from 300 adults with community-acquired pneumonia in the emergency department. The goal is to help doctors quic…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This completed study looked at 179 ICU patients with pneumonia to figure out the best doses of common antibiotics. Researchers took blood and lung fluid samples to measure how the drugs move through the body. The goal was to create personalized dosing plans that ensure enough ant…

This study reviewed the medical records of 239 patients aged 65 and older who had major abdominal surgery. The goal was to find out what factors increase the risk of lung complications like pneumonia or respiratory failure after surgery. By understanding these risks, doctors may …

This study tested whether a special belt that creates images of the lungs (Electrical Impedance Tomography) can safely help doctors choose the best pressure settings on a breathing machine for infants under 3 years old. The study included 14 children with various serious conditio…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This study looked at how the antibiotic ceftobiprole moves through the blood and lungs of 12 adults with severe pneumonia who were on breathing machines. Researchers gave a high dose continuously through a vein and took blood and lung fluid samples to measure drug levels. The goa…

This study tested ways to reduce unnecessary antibiotic use in hospitalized patients being treated for pneumonia, but who had normal breathing and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to s…

This study looked at 1000 patients who needed extra tools to place a breathing tube during surgery. Researchers wanted to see if these patients had a higher chance of lung problems like pneumonia afterward. The goal was to better understand risks and improve patient safety.

This study tested a new AI system (Janus Pro 1B-CXR) designed to help radiologists interpret chest X-rays. The AI was developed using public data and evaluated in 296 patients with suspected chest diseases. Researchers compared report quality, reading time, and agreement between …