PNEUMONIA

This study checked how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia and related infections in adults with HIV. Researchers looked at health records of over 350,000 people with HIV to compare those who got the vaccine with those who did not. The goal was to see i…

This study tested a new 23-valent pneumococcal polysaccharide vaccine to see if it is safe and triggers an immune response. 144 healthy volunteers aged 2 and older received one dose of either the experimental vaccine or a control vaccine. Researchers monitored side effects for up…

This study looked at whether giving children a longer course of antibiotics (amoxicillin-clavulanic acid) improves recovery from pneumonia compared to a shorter course. It involved 314 hospitalized children aged 3 months to 5 years. The goal was to see if longer treatment reduces…

This study looked at whether giving HIV-infected infants (aged 1 month to 1 year) early treatment for two common infections—cytomegalovirus (CMV) and tuberculosis (TB)—could help them survive severe pneumonia. Over 560 babies participated across multiple hospitals. The goal was t…

This study tested two anti-inflammatory drugs, ruxolitinib and fostamatinib, in 185 hospitalized adults with mild to moderate COVID-19 pneumonia. The goal was to see if either drug could prevent the pneumonia from becoming severe, which would require a ventilator or cause death. …

This study tested two methods to reduce unnecessary antibiotic use in hospitalized patients treated for pneumonia who had normal breathing rates and oxygen levels. Over 600 patients were randomly assigned to usual care, an electronic alert, or pharmacist outreach. The goal was to…

This study tested whether using lung ultrasound to guide how ventilated newborns are positioned can prevent ventilator-associated pneumonia better than standard care. Researchers enrolled 80 full-term babies who needed a breathing tube for more than 48 hours. The goal was to see …

This study tested whether training local health workers in remote Indian villages could lower death rates among adults aged 16-60. Over 72,000 people from 80 villages took part. The trained workers provided education, treatment, and referrals for conditions like high blood pressu…

This study tested a new way of using breathing machines in 220 adults with severe COVID-19 lung injury. The goal was to see if using very small breaths (ultraprotective ventilation) could reduce lung damage and improve survival compared to standard care. Participants were randoml…

This study tested a new approach for people with severe COPD: using a simple blood test (eosinophil count) to decide when it's safe to reduce inhaled steroids and when to add an antibiotic (azithromycin). The goal was to lower the risk of flare-ups and hospital stays while avoidi…

This study tested two ways of using a breathing machine during heart bypass surgery to see which one leads to fewer lung problems. Over 1,500 adults having planned heart surgery took part. One group had the breathing machine turned off during bypass, while the other received very…

This study tested a drug called Auxora in 314 people with severe COVID-19 pneumonia. The goal was to see if it helps patients recover faster and reduces the need for breathing machines or death. Participants received either Auxora or a placebo through an IV over 48 hours, along w…

This study tested whether low-dose CT scans or lung ultrasound are more accurate than standard chest X-rays for diagnosing pneumonia in people over 65. About 473 older adults with suspected pneumonia in the emergency room took part. The goal is to see if better imaging can reduce…

This study looked at whether lung ultrasound (LUS) can reliably diagnose pneumonia in children in places where resources are limited. Researchers compared LUS results to a 'gold standard' diagnosis based on all available information, including X-rays and lab tests. The goal was t…

This study looked at whether giving family doctors a small, portable ultrasound machine helps them diagnose and manage 8 common health problems (like pneumonia, kidney stones, and pregnancy concerns) without needing extra tests. Over 160 patients took part, and researchers compar…

This early-phase trial tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein (EGF) that can fuel cancer growth. Researchers measured immune response…

This study looked back at the records of 1000 patients to see if having a difficult breathing tube placement (intubation) during surgery increases the risk of lung problems like pneumonia afterward. The goal was to understand if using special tools beyond the standard laryngoscop…

This study looked at whether the ARISCAT risk score can predict lung complications (like pneumonia or collapsed lung) after major abdominal cancer surgery. Researchers followed 410 adults who had surgery under general anesthesia. The goal was to see if this simple scoring system …

This study looked at 179 ICU patients with pneumonia to figure out the best doses of common antibiotics. Researchers measured drug levels in the blood and lungs to create personalized dosing plans. The goal is to improve treatment success and reduce the risk of drug-resistant inf…

This study tested whether a rapid test (BioFire FA Pneumonia Panel) can help doctors choose the right antibiotics faster for ICU patients on breathing machines who have suspected pneumonia. 40 adults were randomly assigned to get either the rapid test or standard care. The main g…

This study looked at over 30,000 adults hospitalized in Maryland to understand why some patients wait in the emergency room after being admitted (called boarding) and how that affects costs and care. Researchers analyzed existing medical records to find patterns and financial imp…

This study tested a way to help doctors use antibiotics more carefully in patients hospitalized with suspected pneumonia. An electronic alert guided testing to tell if the infection was viral or bacterial. Patients with signs of viral infection were randomly assigned to either re…

This study aimed to find biological markers (biomarkers) in 272 pneumonia patients that could predict outcomes like death or worsening of the disease. Researchers collected data from patients in the hospital but did not test any new treatments. The goal was to better understand t…

This study used health records from 2 million adults in France to see if people who had pneumonia are more likely to develop heart problems later. Researchers compared those who had pneumonia with similar people who did not, tracking heart attacks, strokes, and other major heart …

This study tested whether a special lung imaging technique called Electrical Impedance Tomography (EIT) can safely help doctors choose the best breathing machine pressure for infants and toddlers under 3 years old. The study included 14 children with various serious conditions li…

This study looked at how the antibiotic ceftobiprole spreads in the blood and lungs of 12 adults with severe pneumonia who needed a breathing machine. Researchers gave a high dose continuously for 24 hours and took blood and lung fluid samples to measure drug levels. The goal was…

This study created and tested a simple scoring system called RESPIRE to help doctors quickly identify pneumonia caused by drug-resistant bacteria. Researchers looked at data from 300 adults who came to the emergency room with pneumonia. The goal is to help doctors choose the righ…

This study looked back at medical records of 239 patients aged 65 and older who had major abdominal surgery. The goal was to find out what factors make lung complications like pneumonia more likely after surgery. By identifying these risks, doctors can better prepare and care for…

This study tested a program where rural hospitals connect with infection experts through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant germs. Eight VA medical centers took part, and researchers measured how often an…

This early-stage trial tested the safety of a single dose of an inhaled drug called FLAMOD in 46 healthy adults. The drug is designed to boost the immune system in the lungs to fight pneumonia. The study checked for side effects and measured immune activity to find the best dose …

This study observed over 1,800 children hospitalized for serious breathing issues like bronchiolitis, pneumonia, or asthma. It aimed to track how many children were hospitalized for bronchiolitis after a new immunization became available. The study did not test any new treatment,…

This study tested whether a set of care guidelines helps doctors in community hospitals use proven treatments for children with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across multiple hospitals. The goal was to see if these guidelines lead to better us…

This study looked at how different oxygen level goals and types of oximeters (the clip-on finger device that measures oxygen in the blood) affect the amount of oxygen given to patients with lung diseases like COPD and pneumonia. Researchers tested 40 adults on oxygen therapy to s…