PNEUMONIA

This study looked at how well the Prevnar 13 (PCV13) vaccine works to prevent pneumonia in adults living with HIV. Researchers analyzed existing health records of over 350,000 people to compare rates of pneumonia between those who received the vaccine and those who did not. The g…

This early-stage study tested the safety and initial immune response of a new 23-valent pneumococcal vaccine designed to help prevent pneumonia. It involved 144 healthy volunteers, including children and adults, who received either the test vaccine or a control shot. Researchers …

This study tested whether two existing anti-inflammatory drugs, ruxolitinib and fostamatinib, could help prevent hospitalized COVID-19 pneumonia patients from getting sicker. The goal was to see if these drugs could stop mild or moderate cases from progressing to severe pneumonia…

This study tested whether adding treatments for tuberculosis (TB) and a common virus called cytomegalovirus (CMV) to standard pneumonia care could help more HIV-infected infants survive severe pneumonia. It involved 563 hospitalized babies aged 1-12 months across six African coun…

This study tested if a new drug called Auxora could help hospitalized adults with severe COVID-19 pneumonia. In the main part of the trial, 284 patients were randomly assigned to receive either Auxora or a placebo (inactive substance) infusion over three days, along with standard…

This study tested a gentler way to use breathing machines for hospitalized COVID-19 patients with severe lung failure. Researchers compared the standard method to an 'ultraprotective' method that uses smaller, gentler breaths. The goal was to see if this gentler approach could he…

This study aimed to find out if giving children hospitalized with pneumonia a longer course of antibiotics leads to better health outcomes than a shorter course. Researchers compared two treatment durations in 314 children aged 3 months to 5 years. The goal was to determine the m…

This study tested two methods to help doctors stop unnecessary antibiotics given to hospitalized patients for possible pneumonia. It focused on patients whose breathing rate and oxygen levels were normal, suggesting they might not need the drugs. Researchers compared usual care a…

This study tested a personalized approach to reduce inhaled steroid medication in people with severe COPD. Researchers used regular blood tests to guide when to lower steroid doses, aiming to control COPD flare-ups while reducing medication side effects like pneumonia and diabete…

This large, long-term study tested whether trained village health workers could reduce deaths among working-age adults (16-60 years) in remote tribal villages in India. Over 72,000 participants were involved. The program provided education, basic treatment for common diseases lik…

This study aimed to create and test a simple scoring tool to help doctors quickly identify if a patient's pneumonia is likely caused by bacteria that are resistant to many common antibiotics. Researchers looked at the medical records of 300 adults with pneumonia to find patterns …

This small, completed pilot study tested whether using a rapid lab test could help doctors choose the best antibiotics faster for critically ill patients in the ICU who are on breathing machines and have suspected pneumonia. Forty patients were randomly assigned to either get the…

This study tested whether giving family doctors portable ultrasound machines helps them manage common conditions better. For six months, some doctors used the handheld scanners during patient visits for issues like pneumonia, kidney stones, or pregnancy concerns, while others did…

This study tested three different imaging methods to see which is best at accurately diagnosing pneumonia in people over 65 coming to the emergency room. Researchers compared the standard chest X-ray against a low-dose CT scan and a lung ultrasound. The goal was to see if newer s…

This study tested whether lung ultrasound is a good tool for diagnosing pneumonia in children, especially in areas with limited medical resources. Researchers compared ultrasound results to chest X-rays and a final expert diagnosis based on all available patient information. The …

This study tested if using a safe, painless lung ultrasound to guide how a baby is positioned could better prevent pneumonia in newborns who need a breathing machine. Researchers compared this personalized approach to the standard practice of turning babies every two hours. The g…

This study aimed to understand how a strong antibiotic, ceftobiprole, moves through the bodies of very sick pneumonia patients who need breathing machines. Researchers measured drug levels in the blood and lungs of 12 patients to figure out the best dose to fight the infection. T…

This study looked back at medical records to understand what factors make older adults more likely to develop serious lung problems after major abdominal surgery. Researchers analyzed data from 239 patients aged 65 and older. The goal is to help doctors identify high-risk patient…

This study tested whether a special imaging technique called Electrical Impedance Tomography (EIT) could be used safely to help doctors choose the best pressure settings on breathing machines for infants and toddlers under 3 years old. Researchers enrolled 14 critically ill child…

This study observed and described cases of children hospitalized for serious breathing problems like bronchiolitis, pneumonia, or asthma. It involved 1,827 children under 2 years old across 12 hospitals in France. The main goal was to track these hospitalizations and understand t…

This study looked at whether having pneumonia increases a person's long-term risk of developing serious heart problems like heart attacks or strokes. Researchers compared health records of 2 million people in France, including those who had pneumonia and similar people who did no…

This study aimed to find the best antibiotic doses for treating pneumonia in critically ill ICU patients. Researchers measured how four common antibiotics moved through the blood and into the lung fluid of 179 sedated, ventilated patients. The goal was to gather data to design fu…

This study looked at how the type of finger-clip oxygen monitor (oximeter) and the chosen oxygen target level affect how much oxygen is given to hospitalized patients. It included 40 adults with conditions like COPD or pneumonia who were already on oxygen therapy. Researchers tes…

This study looked back at medical records to see if patients who had a difficult time having a breathing tube placed during surgery were more likely to develop lung problems afterward. Researchers compared 1,000 patients who had a difficult intubation to similar patients who had …