PNEUMONIA

This study aims to measure how well Pfizer's 20-strain pneumonia vaccine protects adults 65 and older from severe, lung infection confirmed by chest imaging. It will enroll 12,500 participants who are hospitalized with suspected pneumonia. Researchers will compare infection rates…

This study is testing a new drug called AV-001 for adults hospitalized with pneumonia from COVID-19 or other infections. The goal is to see if the drug is safe and if it can help patients improve by reducing lung inflammation and damage, potentially helping them breathe better an…

This study is testing if adding a non-invasive brain stimulation technique to standard swallowing therapy can help prevent pneumonia in people who have trouble swallowing after a stroke. It will involve 70 recent stroke patients in Egypt. One group will get the standard therapy p…

This study is testing a therapy called OLE, which uses vibrations to help clear mucus from the lungs of ICU patients with pneumonia. Researchers will use special imaging to see how well the therapy works for different patients. The main goal is to see if it improves the patients'…

This study is testing whether using higher air pressure through a breathing mask helps people with severe pneumonia or ARDS avoid needing a breathing tube inserted down their throat. It will compare high pressure to standard low pressure in over 700 hospitalized patients. The mai…

This study is testing if a special blood filter (called oXiris) works better than a standard filter for pneumonia patients whose kidneys have suddenly stopped working. The goal is to see if the special filter can reduce dangerous inflammation in the blood and help patients surviv…

This study is testing a new ventilator called INBENTUS VERSATILE to see if it is safe and works well for adults who need help breathing. It will involve 81 people in the hospital with conditions like severe pneumonia, COPD, or after surgery. The main goals are to check for seriou…

This study is testing whether doctors can safely give shorter courses of antibiotics to children with complex medical conditions who get pneumonia. Instead of a standard fixed length, treatment will be tailored to stop when each child is clinically stable. The goal is to reduce o…

This small, early-stage study is testing whether high doses of inhaled nitric oxide gas can help critically ill adults with pneumonia who are on breathing machines. Researchers will compare the gas treatment to a placebo to see if it helps patients recover and will closely monito…

This study is testing whether exposure to a special bright blue light can help the body's immune system fight serious infections. It involves 144 adults hospitalized for conditions like pneumonia, severe abdominal infections, or infected joints. Participants are randomly assigned…

This study tests whether computer alerts in hospital systems can help doctors prescribe fewer unnecessary antibiotics to children with common lung infections like pneumonia, bronchiolitis, and asthma flare-ups. It involves 2,800 children at three U.S. hospitals. The goal is to sa…

This study aims to check how well different medical devices measure a patient's blood flow and fluid needs while they are on a special life support machine called ECMO. Researchers will test 30 adult patients in intensive care who are on ECMO for severe lung failure. They will co…

This study is testing a new portable X-ray machine that takes moving pictures of the lungs. It aims to see if this technology is safe and practical to use at the bedside in the Intensive Care Unit (ICU) and if it gives doctors more useful information than standard chest X-rays. R…

This study aims to create a better, more accurate way to diagnose pneumonia in older adults who come to the emergency department. Researchers will observe 250 patients aged 65+ with suspected pneumonia to see if new blood markers can help doctors tell if it's bacterial, viral, or…

This study is following women who received an experimental vaccine against Group B Streptococcus (GBS) during a past pregnancy. The main goals are to see how long their immune protection lasts and to check the safety and effectiveness of giving a booster dose if they become pregn…

This study is testing if a combination of intensive oral hygiene and preventive antibiotics can stop pneumonia from developing in people who have just had a brain hemorrhage. It will involve 440 patients across multiple hospitals in China. The goal is to see if this approach is s…

This study is comparing two different approaches for scheduling follow-up doctor visits after children are hospitalized for common infections like pneumonia or urinary tract infections. Researchers want to see if telling parents to schedule a visit only if needed works as well as…

This study aims to better understand ARDS, pneumonia, and sepsis by observing 4,000 hospitalized adults with these serious conditions. Researchers will collect health data, questionnaires, and samples like blood and urine from participants during and after their hospital stay. Th…

This study aims to understand why infections are common after surgery to remove esophageal cancer and how they affect recovery. Researchers will look back at the medical records of 350 patients who had this surgery in France between 2017 and 2024. By identifying risk factors for …

This study aims to identify specific proteins in lung fluid that could help doctors understand what causes different types of pneumonia. Researchers will analyze fluid samples from 750 patients undergoing a standard lung washing procedure for diagnosis. The goal is to find biolog…

This study aims to check if common hospital devices that monitor heart function and blood flow give accurate readings for patients on a life support machine called VA ECMO. Researchers will test 30 adult patients on this machine by comparing measurements from different devices du…

This study aims to learn more about Hyper IgE Syndrome, a rare immune disorder that causes severe eczema and frequent infections. Researchers will observe 300 patients and 300 of their relatives over time to understand how the disease develops, identify its genetic causes, and im…

This study is testing a new type of lung scan to better understand and measure breathing problems that can occur after a stem cell transplant. Researchers will compare the new scan results with standard breathing tests and CT scans in 25 adult transplant patients. The goal is to …

This study aims to understand why national plans to provide medical oxygen often don't work as intended in practice. Researchers will interview government officials, healthcare workers, and other stakeholders in six African and Asian countries over four years. The goal is to iden…