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New vaccine aims to shield seniors from pneumonia

NCT ID NCT05452941

Vaccine Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing how well a 20-valent pneumococcal vaccine works against pneumonia in adults aged 65 and older. Researchers will compare vaccinated and unvaccinated hospitalized patients with pneumonia to see if the vaccine reduces infections from seven specific bacterial strains. The study aims to enroll 12,500 participants across multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
20-valent pneumococcal conjugate vaccine (20vPnC)
What this could lead to
If successful, this study could confirm that the 20-valent vaccine effectively prevents pneumonia caused by seven additional bacterial strains in older adults.
What could go wrong
This is an observational study, not a randomized trial, so results may be less definitive. The vaccine's effectiveness may vary by population or circulating strains.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 12,500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Males and females ages 65 and older hospitalized for suspected community acquired pneumonia.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female participants ≥65 years of age. 2. Hospitalized participant with physician clinical suspicion of CAP with the presence of ≥2 of the following 10 clinical signs or symptoms: * fever (oral temperature \>38.0°C/100.4°F or tympanic temperature \>38.5°C/101.2°F), * hypothermia (\<35.5°C/95.9°F measured by a healthcare provider) * chills or rigors, * pleuritic chest pain, * new or worsening cough, * sputum production, * dyspnea (shortness of breath), * tachypnea (respiratory rate \>20/min), * malaise, or * abnormal auscultatory findings suggestive of pneumonia (rales or evidence of pulmonary consolidation including dullness on percussion, bronchial breath sounds, or egophony). 3. Has a radiographic finding that is consistent with pneumonia (e.g., pleural effusion, increased pulmonary density due to infection, the presence of alveolar infiltrates \[multi-lobar, lobar, or segmental\] containing air bronchograms). 4. Capable of giving signed informed consent Exclusion Criteria: 1. Any participant who develops signs and symptoms of pneumonia after being hospitalized for ≥48 hours (either at the study site, another transferring hospital, or a combination of these). 2. Received any pneumococcal vaccine ≤30 days prior to enrollment. 3. Unable to provide urine specimen (e.g. anuric). 4. Previous enrollment in the study within the past 30 days.

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Conditions

The condition(s) this trial relates to.

pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pneumonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    53 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Ahuja Medical Center

    RECRUITING

    Beachwood, Ohio, 44122, United States

  • CHUVI- Hospital Alvaro Cunqueiro

    RECRUITING

    Vigo, Pontevedra [pontevedra], 36312, Spain

  • ECU Health Medical Center

    RECRUITING

    Greenville, North Carolina, 27834, United States

  • El Centro Regional Medical Center

    RECRUITING

    El Centro, California, 92243, United States

  • Emek Medical Center

    RECRUITING

    Afula, 1834111, Israel

  • Emory Children's Center - Vaccine Research Clinic (ECC-VRC)

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Emory University Hospital

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Hospital Regional Universitario de Málaga

    RECRUITING

    Málaga, 29010, Spain

  • Hospital Universitari Vall D´Hebron

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitari de Bellvitge

    RECRUITING

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, València, 46026, Spain

  • Hospital Universitario Clinico San Carlos

    RECRUITING

    Madrid, 28040, Spain

  • Hospital Universitario Doctor Peset

    RECRUITING

    Valencia, 46017, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario Severo Ochoa

    RECRUITING

    Leganés, Madrid, 28914, Spain

  • Hospital Universitarios De Getafe

    RECRUITING

    Getafe, Madrid, 28905, Spain

  • Infectious Diseases Unit Tel-Aviv Sourasky Medical Center

    RECRUITING

    Tel Aviv, 6423906, Israel

  • Kaiser Permanente Fontana Medical Center

    RECRUITING

    Fontana, California, 92335, United States

  • Kaiser Permanente Oakland Medical Center

    RECRUITING

    Oakland, California, 96411, United States

  • Kaiser Permanente Ontario Medical Center

    RECRUITING

    Ontario, California, 91761, United States

  • Kaiser Permanente Riverside Medical Center

    RECRUITING

    Riverside, California, 92505, United States

  • Kaiser Permanente Roseville Medical Center

    RECRUITING

    Roseville, California, 95661, United States

  • Kaiser Permanente Sacramento Medical Center

    RECRUITING

    Sacramento, California, 95825, United States

  • Kaiser Permanente San Diego Medical Center

    RECRUITING

    San Diego, California, 92123, United States

  • Kaiser Permanente Santa Clara Medical Center

    RECRUITING

    Santa Clara, California, 95051, United States

  • Kaiser Permanente South Sacramento Medical Center

    RECRUITING

    Sacramento, California, 95823, United States

  • Kaiser Permanente South San Francisco Medical Center

    RECRUITING

    South San Francisco, California, 94080, United States

  • Kaiser Permanente Sunnyside Medical Center

    RECRUITING

    Clackamas, Oregon, 97015, United States

  • Kaiser Permanente Vaccine Study Center

    RECRUITING

    Oakland, California, 94612, United States

  • Kaiser Permanente Walnut Creek Medical Center

    RECRUITING

    Walnut Creek, California, 94596, United States

  • Kaiser Permanente West Los Angeles Medical Center

    RECRUITING

    Los Angeles, California, 90034, United States

  • Kaiser Permanente Zion Medical Center

    RECRUITING

    San Diego, California, 92120, United States

  • MedStar Washington Hospital Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Meir Medical Center

    RECRUITING

    Kfar Saba, 4428164, Israel

  • Memorial Hermann Hospital

    RECRUITING

    Houston, Texas, 77030, United States

  • Michael E. DeBakey VA Medical Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Norton Audubon Hospital

    RECRUITING

    Louisville, Kentucky, 40217, United States

  • Norton Brownsboro Hospital

    RECRUITING

    Louisville, Kentucky, 40241, United States

  • Norton Women's and Children's Hospital

    RECRUITING

    Louisville, Kentucky, 40241, United States

  • Ochsner Baptist Medical Center

    RECRUITING

    New Orleans, Louisiana, 70115, United States

  • Ochsner Clinic Foundation

    RECRUITING

    New Orleans, Louisiana, 70121, United States

  • Ochsner Medical Center - Kenner

    RECRUITING

    Kenner, Louisiana, 70065, United States

  • Robley Rex VA Medical Center

    RECRUITING

    Louisville, Kentucky, 40206, United States

  • Soroka University Medical Center

    RECRUITING

    Beersheba, 8410101, Israel

  • Southern California Permanente Medical Group (SCPMG)

    RECRUITING

    Pasadena, California, 91101, United States

  • Starling Physicians

    ACTIVE_NOT_RECRUITING

    Hartford, Connecticut, 06106, United States

  • Summa Health

    RECRUITING

    Akron, Ohio, 44304, United States

  • Summa Health Clinical Research Center - Specialty

    RECRUITING

    Akron, Ohio, 44304, United States

  • UMass Memorial Medical Center

    RECRUITING

    Worcester, Massachusetts, 01655, United States

  • UNC Hospitals Hillsborough Campus

    RECRUITING

    Hillsborough, North Carolina, 27278, United States

  • University Hospitals Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • University of Louisville School of Medicine, Division of Infectious Diseases

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • University of Maryland

    RECRUITING

    Baltimore, Maryland, 21201, United States

  • UofL Health, Mary & Elizabeth Hospital

    RECRUITING

    Louisville, Kentucky, 40215, United States

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