New vaccine aims to shield seniors from pneumonia

NCT ID NCT05452941

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: Pfizer Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing how well a 20-valent pneumococcal vaccine works against pneumonia in adults aged 65 and older. Researchers will compare vaccinated and unvaccinated hospitalized patients with pneumonia to see if the vaccine reduces infections from seven specific bacterial strains. The study aims to enroll 12,500 participants across multiple sites.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 20-valent pneumococcal conjugate vaccine (20vPnC)
What this could lead to: If successful, this study could confirm that the 20-valent vaccine effectively prevents pneumonia caused by seven additional bacterial strains in older adults.
What could go wrong: This is an observational study, not a randomized trial, so results may be less definitive. The vaccine's effectiveness may vary by population or circulating strains.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PNEUMONIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Ahuja Medical Center
RECRUITING

Beachwood, Ohio, 44122, United States
CHUVI- Hospital Alvaro Cunqueiro
RECRUITING

Vigo, Pontevedra [pontevedra], 36312, Spain
ECU Health Medical Center
RECRUITING

Greenville, North Carolina, 27834, United States
El Centro Regional Medical Center
RECRUITING

El Centro, California, 92243, United States
Emek Medical Center
RECRUITING

Afula, 1834111, Israel
Emory Children's Center - Vaccine Research Clinic (ECC-VRC)
RECRUITING

Atlanta, Georgia, 30322, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Hospital Regional Universitario de Málaga
RECRUITING

Málaga, 29010, Spain
Hospital Universitari Vall D´Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitari de Bellvitge
RECRUITING

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, València, 46026, Spain
Hospital Universitario Clinico San Carlos
RECRUITING

Madrid, 28040, Spain
Hospital Universitario Doctor Peset
RECRUITING

Valencia, 46017, Spain
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Severo Ochoa
RECRUITING

Leganés, Madrid, 28914, Spain
Hospital Universitarios De Getafe
RECRUITING

Getafe, Madrid, 28905, Spain
Infectious Diseases Unit Tel-Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
Kaiser Permanente Fontana Medical Center
RECRUITING

Fontana, California, 92335, United States
Kaiser Permanente Oakland Medical Center
RECRUITING

Oakland, California, 96411, United States
Kaiser Permanente Ontario Medical Center
RECRUITING

Ontario, California, 91761, United States
Kaiser Permanente Riverside Medical Center
RECRUITING

Riverside, California, 92505, United States
Kaiser Permanente Roseville Medical Center
RECRUITING

Roseville, California, 95661, United States
Kaiser Permanente Sacramento Medical Center
RECRUITING

Sacramento, California, 95825, United States
Kaiser Permanente San Diego Medical Center
RECRUITING

San Diego, California, 92123, United States
Kaiser Permanente Santa Clara Medical Center
RECRUITING

Santa Clara, California, 95051, United States
Kaiser Permanente South Sacramento Medical Center
RECRUITING

Sacramento, California, 95823, United States
Kaiser Permanente South San Francisco Medical Center
RECRUITING

South San Francisco, California, 94080, United States
Kaiser Permanente Sunnyside Medical Center
RECRUITING

Clackamas, Oregon, 97015, United States
Kaiser Permanente Vaccine Study Center
RECRUITING

Oakland, California, 94612, United States
Kaiser Permanente Walnut Creek Medical Center
RECRUITING

Walnut Creek, California, 94596, United States
Kaiser Permanente West Los Angeles Medical Center
RECRUITING

Los Angeles, California, 90034, United States
Kaiser Permanente Zion Medical Center
RECRUITING

San Diego, California, 92120, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Meir Medical Center
RECRUITING

Kfar Saba, 4428164, Israel
Memorial Hermann Hospital
RECRUITING

Houston, Texas, 77030, United States
Michael E. DeBakey VA Medical Center
RECRUITING

Houston, Texas, 77030, United States
Norton Audubon Hospital
RECRUITING

Louisville, Kentucky, 40217, United States
Norton Brownsboro Hospital
RECRUITING

Louisville, Kentucky, 40241, United States
Norton Women's and Children's Hospital
RECRUITING

Louisville, Kentucky, 40241, United States
Ochsner Baptist Medical Center
RECRUITING

New Orleans, Louisiana, 70115, United States
Ochsner Clinic Foundation
RECRUITING

New Orleans, Louisiana, 70121, United States
Ochsner Medical Center - Kenner
RECRUITING

Kenner, Louisiana, 70065, United States
Robley Rex VA Medical Center
RECRUITING

Louisville, Kentucky, 40206, United States
Soroka University Medical Center
RECRUITING

Beersheba, 8410101, Israel
Southern California Permanente Medical Group (SCPMG)
RECRUITING

Pasadena, California, 91101, United States
Starling Physicians
ACTIVE_NOT_RECRUITING

Hartford, Connecticut, 06106, United States
Summa Health
RECRUITING

Akron, Ohio, 44304, United States
Summa Health Clinical Research Center - Specialty
RECRUITING

Akron, Ohio, 44304, United States
UMass Memorial Medical Center
RECRUITING

Worcester, Massachusetts, 01655, United States
UNC Hospitals Hillsborough Campus
RECRUITING

Hillsborough, North Carolina, 27278, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Louisville School of Medicine, Division of Infectious Diseases
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
UofL Health, Mary & Elizabeth Hospital
RECRUITING

Louisville, Kentucky, 40215, United States

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