PNEUMONIA

This study looks at health records of over 800,000 adults to see if the PCV20 vaccine reduces pneumonia cases. Researchers will compare pneumonia rates in people who got the vaccine versus those who did not. The goal is to measure how effective PCV20 is in adults aged 18 and olde…

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to either a 5-day or 10-day course, with some receiving a placebo a…

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This study looks at whether treating patients at home for conditions like infections, heart failure, diabetes, and COPD can lead to better health outcomes and satisfaction compared to traditional hospital stays. Nearly 10,000 adults will receive hospital-level care at home, inclu…

This study is testing a new diagnostic tool called RPIP, which uses advanced DNA sequencing to quickly identify the germs causing pneumonia and their drug resistance. The goal is to see if this method helps doctors choose the right treatment faster than current tests. The study w…

This study tests whether a new DNA-sequencing technique (metagenomic next-generation sequencing) can identify the cause of pneumonia faster than standard methods. About 114 ICU patients on ventilators will be randomly assigned to receive either the new test or usual care. The goa…

This study tests whether virtual reality (VR) can improve how caregivers learn chest percussion techniques for children with pneumonia. About 60 caregivers will be randomly assigned to VR training or standard teaching. The goal is to see if VR boosts skill accuracy, knowledge, an…

This early-stage study is testing a new tablet version of the COVID-19 drug ibuzatrelvir in 18 healthy adults. Researchers want to see how much of the drug gets into the blood when taken as a whole tablet, dispersed in water, or with food. The goal is to compare the new tablet to…

This study follows 100 adults hospitalized in intensive care units with severe pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how many survive. They will also check for antibiotic resi…

This study looks at 1,800 adults hospitalized with pneumonia in Hong Kong. Researchers use a simple urine test to identify which types of pneumococcus bacteria are causing the infections. The goal is to understand which strains are most common, which can help improve future vacci…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study looks at whether a procedure called flexible bronchoscopy can help doctors find the exact germ causing pneumonia in children who are not getting better with standard antibiotics. The study will include 58 children in the intensive care unit at a hospital in Cairo. If i…

This study tests whether a hospital-customized plan (ROAD Home) reduces unnecessary antibiotic use at discharge for adults with pneumonia or urinary tract infections. Forty hospitals are randomly assigned to either use this tailored approach or continue their usual practices. The…

This study was designed to see if a harmless marker (quinine) placed in the mouth could show up in lung secretions, indicating that fluid is leaking past the breathing tube's cuff. It aimed to help detect aspiration in critically ill patients on ventilators. However, the study wa…

This study examines medical records of 1,100 children under 18 from hospitals across China who were hospitalized with RSV-positive bronchiolitis or pneumonia between 2017 and 2021. Researchers aim to understand how the disease is diagnosed and treated, and what it costs families …

This study looks at 120 adults getting a left ventricular assist device (LVAD) to see how often infections happen and how their immune system changes after surgery. The goal is to find what makes some patients more likely to get infections. This research does not test a new treat…

This study measures how well certain antibiotics penetrate the lungs in patients with pneumonia. Researchers will compare antibiotic levels in the blood and in lung fluid from 101 adults who need a bronchoscopy. The goal is to find factors that predict good lung penetration, whic…