PNEUMONIA

This study looks at health records of over 800,000 adults to see how well the PCV20 vaccine prevents pneumonia and other lung infections. It focuses on people aged 18 and older who have a higher risk of getting pneumococcal disease. The goal is to compare pneumonia rates between …

This study follows healthy pregnant women who previously received an experimental Group B Streptococcus (GBS) vaccine to see how long their immune protection lasts. It also tests whether a booster dose given during a new pregnancy is safe and boosts immunity, aiming to protect ne…

This study tests whether a single low-dose radiation treatment to the lungs can reduce inflammation in adults hospitalized with COVID-19 pneumonia. The goal is to see if this approach lowers the need for a breathing tube or shortens hospital stays. About 37 participants will rece…

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to receive either a 5-day or 10-day course, with some taking a plac…

This study tests whether a new DNA test (mNGS) can help doctors identify the bacteria or virus causing pneumonia faster than standard methods. About 114 ICU patients on breathing machines will be randomly assigned to get either the new test or usual care. The goal is to see if fa…

This study looks at whether a thin, flexible tube with a camera (bronchoscopy) can help find the exact germ causing pneumonia in children who are not getting better with standard antibiotics. About 58 children in the pediatric ICU will have this procedure to collect lung samples.…

This study looks at 100 adults hospitalized in intensive care with pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how many survive. They also check for antibiotic resistance to help im…

This study looks at 120 adults receiving a left ventricular assist device (LVAD), a mechanical heart pump. Researchers want to understand how often infections happen after surgery and how the immune system changes. The goal is to find risk factors that could predict who might get…

This study involves 40 hospitals to see if a customized antibiotic stewardship program reduces unnecessary antibiotic use when patients leave the hospital. It focuses on adults hospitalized with pneumonia or urinary tract infections. The approach is tailored to each hospital's ne…

This study looks at which types of pneumococcus bacteria cause pneumonia in people admitted to Hong Kong hospitals. Researchers will use a simple urine test to identify the bacteria. The goal is to understand which strains are most common, which can help improve vaccines and trea…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study aims to find out why some antibiotics don't reach the lungs well enough to fight pneumonia. Researchers will measure antibiotic levels in the blood and in lung fluid from 101 adults who are already having a bronchoscopy. The goal is to identify factors that predict goo…

This study looks at a new program at UCLA Health called the Next Day Clinic (NDC). Instead of admitting low-risk patients from the emergency room for conditions like pneumonia or heart failure, the NDC sends them home and schedules a high-acuity clinic visit the next day. The goa…

This study aimed to see if quinine could be used as a marker to detect aspiration (leakage of fluids into the lungs) in critically ill patients on breathing machines. The plan was to collect samples from the mouth and windpipe to measure quinine levels. However, the study was wit…