Blood test may help severe COPD patients reduce steroid use safely

NCT ID NCT04481555

Completed Disease control Sponsor: Chronic Obstructive Pulmonary Disease Trial Network, Denmark Source: ClinicalTrials.gov ↗

First seen Feb 01, 2026 · Last updated May 09, 2026 · Updated 11 times

Summary

This study tested a new approach for people with severe COPD: using a simple blood test (eosinophil count) to decide when it's safe to reduce inhaled steroids and when to add an antibiotic (azithromycin). The goal was to lower the risk of flare-ups and hospital stays while avoiding unnecessary medication. The trial involved 444 adults with severe COPD who were already on triple therapy.

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Contacts and locations

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Locations

Aarhus University Hospital

Aarhus, Denmark
Gentofte Hospital

Hellerup, Denmark
Hvidovre Hospital

Copenhagen, Denmark
Nordsjællands Hospital

Hillerød, Denmark
Næstved-Slagelse-Ringsted Sygehus

Næstved, Denmark
Odense University Hospital

Odense, Denmark
Roskilde Sygehus

Roskilde, Denmark
Silkeborg Sygehus

Silkeborg, Denmark
Sydvestjysk Sygehus Esbjerg

Esbjerg, Denmark

Conditions

Explore the condition pages connected to this study.

AZITHROMYCIN COPD COPD EXACERBATION INHALED CORTICOSTEROID PNEUMONIA