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Blood test may help severe COPD patients safely reduce steroids

NCT ID NCT04481555

Completed Disease control Sponsor: Chronic Obstructive Pulmonary Disease Trial Network, Denmark Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a personalized approach for people with severe COPD. Doctors used a simple blood test (eosinophil count) to decide whether to reduce inhaled steroids, and some patients also received the antibiotic azithromycin. The goal was to see if this strategy could reduce serious flare-ups and hospital stays. 444 patients took part, and the results could lead to safer, more tailored treatment plans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
azithromycin and inhaled corticosteroids (ICS)
What this could lead to
If successful, this approach could help personalize COPD treatment, reducing unnecessary steroid use and preventing severe flare-ups.
What could go wrong
This is a completed Phase 4 trial, but results may not apply to all COPD patients. Azithromycin can cause antibiotic resistance and side effects like hearing loss or heart rhythm issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AZITHROMYCIN COPD COPD EXACERBATION INHALED CORTICOSTEROID PNEUMONIA

Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, Denmark

  • Gentofte Hospital

    Hellerup, Denmark

  • Hvidovre Hospital

    Copenhagen, Denmark

  • Nordsjællands Hospital

    Hillerød, Denmark

  • Næstved-Slagelse-Ringsted Sygehus

    Næstved, Denmark

  • Odense University Hospital

    Odense, Denmark

  • Roskilde Sygehus

    Roskilde, Denmark

  • Silkeborg Sygehus

    Silkeborg, Denmark

  • Sydvestjysk Sygehus Esbjerg

    Esbjerg, Denmark

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