COPD

This study is testing how an inhaled medication called BGF 160 affects breathing patterns in people with stable COPD. Researchers will measure changes in how patients breathe and their lung function after using the medication. The study involves 35 participants aged 40-75 with mo…

This study aims to figure out which specific parts of COPD self-management programs are most effective at keeping people out of the hospital and improving their quality of life. Researchers will test three main components—education, inhaler training, and physical activity—in diff…

This study is testing a one-time medical procedure called the dNerva Lung Denervation System. It aims to improve lung function and breathing for people with moderate to severe COPD who are already on standard medications. Researchers will compare the new procedure plus standard c…

This study is testing a new type of exercise training for people with COPD, a chronic lung disease. Researchers want to see if a special 'eccentric' cycling program, which is designed to be easier on breathing, can improve patients' fitness, immune system function, and blood flow…

This study is testing whether suddenly ill adults with conditions like infections, heart failure, or breathing problems can be safely treated at home instead of in a hospital. About 3,000 participants will receive hospital-level care at home with doctors, nurses, tests, and treat…

This study is testing whether an 8-week exercise program done at home or in the community can improve fitness and quality of life for adults with reduced heart or lung function. Researchers will compare 200 participants who do the exercise program to those who do not. The program…

This study is testing a new nasal oxygen cannula design against the standard one to see if it helps people during a COPD flare-up. It will measure if the new design helps patients breathe easier, lowers carbon dioxide levels more, and reduces the need for more intensive breathing…

This study is testing a new medical device called the IAB 50 Flex, which is a small, flexible implant placed in the airways. It aims to help adults with severe emphysema or COPD breathe more easily by supporting damaged lung tissue. The trial will enroll 20 participants at two ho…

This study is testing if using a positive airway pressure (PAP) machine at night helps older veterans who have both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea. Researchers want to see if the machine reduces daytime sleepiness, improves sleep quality …

This study is testing whether an automated oxygen delivery system can keep oxygen levels in the right range better than manual adjustments by hospital staff. It involves 70 hospitalized COPD patients who need extra oxygen through a nasal high-flow device. The goal is to see if th…

This study is testing whether remote nursing support can help people with COPD take better care of their oral health. Researchers will give one group of 80 hospitalized patients education via video call and daily reminders, while another group receives no special education. The g…

This study is testing a new type of clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of specialists to create a treatment plan. Researchers want to see if this approach helps patients gain muscle, get stronger, …

This study tests whether adding a home-based breathing muscle training program to usual care can help patients with severe COPD flare-ups avoid being readmitted to the hospital or dying. Researchers will compare 358 patients who either do the breathing exercises with smartphone m…

This early-stage study is checking the safety and how the body processes a new inhaler medication called HRS-9821. It will test a single dose in 160 healthy volunteers and multiple doses in people with COPD. The main goal is to see what side effects occur and how the drug moves t…

This study is testing whether a new inhaled medicine called ensifentrine can reduce harmful inflammation in the lungs of people with COPD. 56 participants with moderate to severe COPD will use the medicine or a placebo inhaler twice daily for 8-week periods, with researchers meas…

This study is testing a new drug called solrikitug to see if it is safe and how it works in people with COPD. About 171 adults with moderate to severe COPD will receive either the drug or a placebo as a shot for 12 weeks, while continuing their usual medications. Researchers will…

This study is testing a small, permanent implant designed to prop open airways in the lungs of people with severe COPD and emphysema. The goal is to see if this device can safely release trapped air and help patients breathe easier when standard medications aren't enough. About 2…

This study is testing a new smartphone app called AWARE that uses your phone's microphone and speakers to listen to your breathing. The goal is to see if it can accurately help doctors diagnose lung diseases like asthma and COPD, and spot when symptoms are getting worse. Research…

This study aims to develop a non-invasive MRI scan to identify patients with certain lung diseases and high blood pressure in the lungs who might respond to specific medications. Researchers will use a special gas-based MRI scan on 30 patients with conditions like COPD or pulmona…

This study aims to see if two new, easier-to-perform breathing tests can help primary care doctors accurately diagnose asthma and COPD. It will involve 600 adults with symptoms but no prior diagnosis. The goal is to compare the accuracy of these new tests performed in a regular d…

This study aims to see if finding and treating people with undiagnosed asthma or COPD early can make them feel better. Researchers will use an online questionnaire to find adults with breathing symptoms but no diagnosis. Those likely to have asthma or COPD will join a trial where…

This study is testing whether a home-based program combining walking with Tai Chi exercises can help Veterans with COPD (a lung disease) who also have long-term muscle or joint pain. The program is delivered online and aims to improve how much people can walk and move around, whi…

This study is testing whether a 12-week coping skills training program can help reduce depression and anxiety in people with COPD (chronic obstructive pulmonary disease). It will compare the training program to a simpler COPD education program. The study is enrolling 750 patient-…

This study is testing a new interactive training device that gives people feedback on how to use their inhaler correctly. It will enroll 140 adults with COPD or asthma to see if using the training device for 6 weeks improves their technique and breathing compared to standard educ…

This study is testing if adding music to standard rehabilitation training helps people with COPD and chronic breathing problems. Researchers want to see if listening to music during exercise helps patients walk farther, feel less shortness of breath, and get less tired. They will…

This study is testing if adults with COPD and chronic bronchitis feel better if they switch from regular cigarettes to a tobacco heating system (THS), which heats tobacco instead of burning it. About 290 participants will be randomly assigned to either switch to THS or continue s…

This study is testing if a very low dose of fentanyl, given as a spray under the tongue, can help people with severe COPD breathe easier during exercise. It will involve about 40 participants who still struggle with breathlessness despite taking standard medications, including lo…

This observational study aims to better understand Chronic Obstructive Pulmonary Disease (COPD) in Chinese patients. Researchers will follow 850 participants with COPD or early signs of the disease for 1-3 years, collecting health data, lung function tests, and blood samples. The…

This study aims to see if two simple tools—a tape measure around the thigh and a special type of ultrasound—can reliably track muscle health in people with COPD. Researchers will follow 30 adults with COPD who are starting a pulmonary rehabilitation program. The goal is to find b…

This study aims to better understand Chronic Obstructive Pulmonary Disease (COPD) in people who are already getting screened for lung cancer. Researchers will collect health information from 420 current or former heavy smokers over about 15 months. The goal is to learn how COPD a…

This study aims to understand how air pollution causes serious diseases like lung cancer, COPD, and leukemia. Researchers will compare pollution levels found in the bodies of 300 non-smoking patients with these conditions to levels in healthy volunteers. The goal is to find new b…

This study aims to learn how to better predict which COPD patients with high carbon dioxide levels will respond well to long-term nighttime breathing support (non-invasive ventilation). Researchers will observe 25 patients for one year, collecting data on their breathing patterns…

This study aims to understand if weakness in the main breathing muscle (the diaphragm) is common in people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension, and if it can predict future health problems. Researchers will measure muscle strength, lung funct…

This study aims to collect genetic and health information from 3,000 people to understand how genes affect medication responses. The goal is to help doctors prescribe the right drugs and doses to avoid harmful side effects, especially for people taking multiple medications. Resea…

This study is testing whether a simple ultrasound measurement of the diaphragm (the main breathing muscle) can predict which patients hospitalized for a severe COPD flare-up will get worse and need breathing support or might die. Researchers will scan about 186 patients when they…

This study aims to learn how chronic obstructive pulmonary disease (COPD) affects the heart, especially during exercise. Researchers will measure heart function in 60 people with COPD at rest and during different exercise intensities. The goal is to identify patterns of heart str…

This study aims to understand if people with a specific genetic form of Alpha-1 Antitrypsin Deficiency (AATD) also have variations in nearby genes that weaken their immune system and lead to more lung infections. Researchers will compare the immune response to a pneumonia vaccine…

This study aims to understand why some people with COPD continue to experience severe, treatment-resistant breathlessness. Researchers will follow 730 patients over time, comparing those who don't improve with standard inhalers to those who do. The goal is to identify factors tha…

This study aims to understand why the body's 'fight-or-flight' nervous system is overactive in people with Chronic Obstructive Pulmonary Disease (COPD). Researchers will measure nerve activity in 135 adults with COPD and compare them to healthy people to see if sleep apnea, lung …

This study aims to better understand how COPD changes over time. Researchers will follow 100 adults with COPD for one year, checking their breath and a small blood sample every six months. The goal is to see if certain markers in the breath or blood are different in people whose …

This study aims to find out how common asthma and chronic obstructive pulmonary disease (COPD) are among workers in an industrial area of Thailand. Researchers will survey 310 adult workers about their breathing symptoms and test their lung function. The goal is to gather informa…

This study aims to understand how two lung conditions—COPD and a related pattern called PRISm—affect muscle strength, exercise ability, and how muscles use oxygen. Researchers will measure these factors in 60 people: those with COPD, those with PRISm, and healthy individuals for …

This study aims to understand how fungi from the gut might move into the bloodstream and affect lung health in people living with HIV. Researchers will enroll 100 adults with HIV to measure markers of fungal movement, gut health, and lung function over three years. The goal is to…