COPD

This study tests whether a simple home breathing exercise can help people with COPD avoid going back to the hospital after a serious flare-up. About 358 adults who were hospitalized for at least 3 days will either do daily breathing training with a smartphone app plus usual care,…

This study tests a new clinic designed to find and treat muscle loss (sarcopenia) in people with COPD. About 80 adults hospitalized for COPD will join a team of lung doctors, nurses, and a pharmacist who will use CT scans and other tests to diagnose muscle loss and provide target…

This study tests whether treating suddenly ill adults at home is as safe and effective as hospital care. About 3,000 participants with conditions like infections, heart failure, or COPD will receive hospital-level care at home. The goal is to see if home care can lower costs and …

This study tests a self-management program for people with COPD to see which parts work best to reduce hospital stays and improve daily life. Researchers will enroll 448 adults aged 40+ who have had a COPD-related hospitalization in the past year. Participants will use a smartpho…

This study is for people with COPD who need steroid tablets for flare-ups at least three times a year. Participants get a half-day hospital check-up to ensure they have the right diagnosis and treatment, and to find other health problems that might be mistaken for COPD. The goal …

This study tests a one-time treatment called lung denervation for people with COPD. The procedure targets nerves in the lungs to help open airways and improve breathing. Researchers will compare lung function in 200 adults who receive the treatment plus standard care versus those…

This study tests a new medicine, solrikitug, in people with chronic obstructive pulmonary disease (COPD). The goal is to see if it can safely lower certain immune cells (eosinophils) and improve lung function. About 171 adults aged 40–75 with moderate-to-severe COPD will receive …

This study tests a new device called the IAB 50 Flex, an implant designed to help people with severe emphysema or COPD breathe easier. About 20 adults will receive the implant at two hospitals. The main goal is to check for serious side effects within 90 days.

This study tests an inhaled drug called ensifentrine in 56 adults with COPD, a chronic lung disease. Participants will receive both the drug and a placebo at different times to see if the drug reduces inflammation in the lungs. The goal is to find a new way to control COPD sympto…

This study tests a new device called an implantable artificial bronchus (IAB) for people with severe emphysema or COPD. The goal is to see if the device can improve lung function and make breathing easier. About 60 adults who have trouble breathing despite stable treatment will r…

This study looks at whether finding and treating COPD early can help people who are also being evaluated for lung cancer. About 280 adults with breathing problems will get early COPD treatment or standard care. Researchers will track symptoms, weight, and exercise ability over 6 …

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system (THS) experience fewer symptoms like coughing and shortness of breath, and see improvements in lung function and walking ability. The study will comp…

This study tests a permanent implant called the Apreo BREATHE system, which props open airways to release trapped air in the lungs of people with COPD and emphysema. The goal is to improve breathing and quality of life. Up to 250 adults aged 40-84 who still have shortness of brea…

This study aims to see if two easy breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD without needing complex equipment. About 600 adults with symptoms like wheezing or shortness of breath will take these tests at their local c…

This study tests if a smartphone app can listen to your breathing and detect lung problems like asthma, COPD, or cystic fibrosis. Researchers will compare the app's results to standard breathing tests. If successful, this could make lung health checks easier and more accessible, …

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases like COPD, pneumonia, and pneumothorax. Researchers will enroll 700 adults with various lung conditions and healthy volunteers t…

This study tests if a program combining walking and Tai Chi can help veterans with COPD (a lung disease) and long-term muscle or joint pain move around better. About 136 veterans aged 40 and older will use a FitBit to track their steps and report their pain and breathing. The goa…

This study compares a new asymmetric nasal high-flow interface to a standard nasal cannula in 50 people with mild-to-moderate COPD exacerbations. Participants will wear each device for 3 hours to see which better lowers carbon dioxide levels, reduces breathing rate, and is more c…

This study tests a new, smart exercise program for people with COPD. The goal is to see if this type of training can improve heart and lung fitness, muscle strength, immune function, and quality of life. Researchers will enroll 170 adults with COPD who have already completed at l…

This study tests whether telenursing (nurse support by phone or video) can improve oral health in 80 adults with COPD. Participants will receive remote guidance on mouth care, and their oral health and quality of life will be measured before and after. The goal is to see if this …

This study tests whether a device called Airvo 3 in OptiO2 mode can automatically keep oxygen levels in a healthy range for hospitalized COPD patients. About 70 adults with COPD and low oxygen will take part. The goal is to see if the smart device works better than nurses manuall…

This study tests a device that coaches people with COPD or asthma on how to use their inhalers correctly. About 140 adults will either use the device or get brief standard training. After 6 weeks, researchers check if the device improves inhaler technique and reduces hospital vis…

This study looks at whether a 12-week Coping Skills Training program can reduce depression and anxiety in people with COPD, especially those facing health disparities. Researchers will compare it to a standard COPD education program. Participants attend weekly sessions and comple…

This study is testing a new 3-month counseling program for people with stable COPD. The program focuses on emotional distress and is led by a specialized nurse team. Researchers want to see if this approach is practical and helpful for patients. The study involves 15 participants…

This study looks at whether using a nasal high-flow device during a 6-minute walk test helps people with COPD walk farther and feel less breathless. About 30 adults with COPD who use little or no extra oxygen will take part. Researchers will compare how far they walk and how hard…

This study looks at whether adding music to standard rehabilitation exercises helps people with COPD and chronic respiratory failure walk farther and feel less tired or short of breath. About 156 participants will be randomly assigned to exercise with or without music. The goal i…

This study looks at whether exercising in your community or at home can improve how well your heart and lungs work. Researchers will compare people who exercise regularly with those who don't. The goal is to find a safe and effective way for people with conditions like heart dise…

This study tests whether dronabinol, a synthetic THC (the active ingredient in cannabis), can reduce severe breathlessness in people with advanced COPD. About 30 participants will receive both the drug and a placebo at different times to compare effects. The goal is to see if it …

This study looks at whether interval exercise can improve daily activity, reduce daytime sleepiness, and support heart health in veterans who have both COPD and sleep apnea (called Overlap Syndrome). About 28 veterans will take part in a 12-week program. The goal is to find a saf…

This early-stage study tests a new inhaled medicine called HRS-9821 in 160 people. First, healthy volunteers get a single dose to check safety. Then, people with COPD take multiple doses to see if it helps control their condition. The main goal is to find out if the drug is safe …

This study tests a small, hands-free device called the PEP-buddy that helps people with COPD breathe easier during sudden episodes of breathlessness. The device works by creating gentle pressure when you breathe out. Researchers will study 25 adults with COPD to see if using the …

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea. About 668 participants will use PAP therapy and be tested on memor…

This study looks at whether measuring thigh size with a tape measure and muscle stiffness with a special ultrasound can help track muscle health in people with COPD. About 30 adults starting pulmonary rehabilitation will take part. The goal is to find a simple, non-invasive way t…

This study is translating and testing a questionnaire (Nijmegen Questionnaire) in Turkish to help identify dysfunctional breathing in people with stable COPD. Researchers will enroll 90 adults with COPD to see if the Turkish version is accurate and reliable. The goal is to give d…

This study looks at how the right side of the heart works during rest and exercise in people with COPD. Researchers want to find different patterns of heart strain to guide future treatments. About 60 adults aged 40 and older with COPD will take part. The goal is to better unders…

This study collects genetic and health information from 3,000 people to help doctors choose safer and more effective medications. Participants have conditions like diabetes, high blood pressure, heart disease, or cancer, and take multiple medications. The goal is to learn how gen…

This study looks at how different types of exercise change oxygen levels in the brain and leg muscles of people with COPD. Researchers will compare 60 participants (COPD patients and healthy volunteers) using special light-based sensors during walking, strength, and breathing exe…

This study is testing a new type of MRI that uses a special gas (xenon) to take detailed pictures of lung function. It will include 260 healthy volunteers and people with various lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this imaging method can b…

This study aims to find out how common asthma and COPD are among workers in an industrial zone in Thailand. About 310 workers aged 18 and older will fill out a questionnaire about breathing problems and take a lung function test. The results will help understand the impact of wor…

This study aims to find out if people with alpha-1 antitrypsin deficiency (AATD) also have nearby gene changes that weaken their immune system and lead to more lung infections. Researchers will compare immune responses to a pneumonia vaccine in 30 adults who have one abnormal AAT…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart dysfunction that could lead to better treatments. The study involves 60 adults aged 40 and older with CO…

This study looks at how well muscles work and use oxygen in people with COPD, those with a lung condition called PRISm, and healthy adults. Researchers will measure breathing muscle strength, arm and leg exercise ability, and muscle oxygen levels. The goal is to better understand…

This study looks at 25 adults with COPD and high carbon dioxide levels who need a breathing machine at night. Researchers want to see if problems breathing during sleep can predict how well the machine works over 6 to 12 months. The goal is to better understand who benefits most …

This study is observing 850 people with COPD in China to understand how the disease progresses and what factors affect it. Researchers will collect medical history, lung function tests, and blood samples over 1 to 3 years. The goal is to identify different types of COPD and find …

This study looks at whether an ultrasound measurement of the diaphragm can help predict which patients hospitalized with a COPD flare-up will get worse and need breathing support or die. Researchers will measure diaphragm motion during normal and deep breathing in 186 participant…

This study follows 100 adults with COPD for one year to see how airway inflammation, measured by a simple breath test (FeNO) and a small blood sample, changes over time. Participants attend three routine visits (start, 6 months, 12 months) and receive no new treatments. The goal …

This study looks at how the inhaled medication BGF 160 changes the way people with stable COPD breathe. Researchers will measure breathing complexity and lung function in 35 adults aged 40-75. The goal is to understand how the drug works, not to test if it cures or controls the d…

This study looks at whether fungi moving from the gut into the blood cause inflammation and worsen lung function in people with HIV. Researchers will measure fungal markers and lung health in 100 participants over three years. The goal is to understand why some people with HIV de…

This study looks at why the sympathetic (fight-or-flight) nervous system is overactive in people with COPD. Researchers will measure nerve activity, heart rate, and blood pressure in 135 adults with COPD. The goal is to understand how sleep apnea, lung function, and inflammation …

This study is testing a digital tool that includes an app and a home spirometer to help people with COPD monitor their lung function daily. The goal is to see if the tool is easy to use, safe, and can help patients know when to seek medical care. Fifty adults with COPD who have h…

This study looks at people who are already getting lung cancer screening to find and track those who also have COPD. Researchers will collect information on symptoms, lung function, and CT scans from 420 participants. The goal is to better understand and manage COPD in this group…

This study follows 730 adults with COPD who still have severe shortness of breath even after using standard inhalers. Researchers will track their health over time to find out which factors lead to more flare-ups, faster lung decline, or death. The goal is to better understand th…

This study looks at how a treatment called bronchoscopic lung volume reduction with endobronchial valves changes oxygen use during daily activities in people with severe COPD. About 20 patients scheduled for this treatment will perform simple tasks while wearing a portable oxygen…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will complete an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their primary care doctor or usual ca…

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. Participants will do walking and sitting tests to measure br…

This study aims to find a noninvasive way to detect changes in lung blood vessels in people with a type of pulmonary hypertension (Group 3 PH) caused by lung diseases like COPD or interstitial lung disease. Researchers will use a special MRI technique (hyperpolarized 129Xe MRI) t…