COPD

This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the v…

This study is testing the long-term safety of a drug called tozorakimab in people with chronic obstructive pulmonary disease (COPD) who have had flare-ups in the past. About 82 participants who completed earlier studies will receive tozorakimab and be monitored for side effects. …

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …

This study tests a new device called the IAB 50 Flex, an implantable artificial bronchus for adults with severe COPD or emphysema. The trial will enroll 20 participants across two hospitals to check if the implant is safe and if it helps improve breathing and daily activity. The …

This study tests a new device called an implantable artificial bronchus (IAB) for people with severe emphysema or COPD. The IAB is designed to help air move in and out of the lungs more easily. About 60 adults will receive the implant and be followed for 90 days to see if it impr…

This study tests whether a home-based breathing exercise program can reduce hospital readmissions and deaths in people recovering from a severe COPD flare-up. About 358 participants will either receive usual care or add daily inspiratory muscle training using a smartphone-connect…

This study tests whether a detailed, personalized care plan—including diet, exercise, and counseling—can reduce hospitalizations and improve quality of life for people with COPD who have recently been hospitalized. About 110 adults aged 40 and older who smoke or used to smoke wil…

This study tests whether a nebulized drug called ensifentrine can reduce inflammation in the lungs of people with COPD. About 56 adults aged 40-80 who smoke or have smoked will receive both the drug and a placebo at different times over 24 weeks. The main goal is to see changes i…

This study tests a one-time procedure called lung denervation for people with COPD who are already on standard care. The goal is to see if it safely improves lung function and breathing over 6 months. About 200 adults aged 40-80 who have smoked heavily in the past will take part.

This study tests a permanent implant called the Apreo BREATHE Airway Scaffold in up to 250 adults with COPD and emphysema who still feel short of breath despite standard treatments. The implant is designed to prop open airways and release trapped air to improve breathing. Researc…

This study looks at whether giving early, tailored COPD treatment to people being evaluated for lung cancer can improve their breathing and overall health. About 280 participants will receive either standard care or extra COPD consultations focusing on medication, smoking cessati…

This Phase 2 trial tests solrikitug, a biologic drug given as a shot, in 171 adults with moderate-to-severe COPD and high eosinophil levels. The study compares two doses of solrikitug against a placebo to see if it safely reduces inflammation and improves lung function over time.…

This study is testing whether adults with sudden illnesses like infections, heart failure, or COPD can be safely treated at home instead of in a hospital. Researchers will compare costs, patient experience, and health outcomes for 3,000 participants who receive hospital-level car…

This study tests a smart eccentric cycling exercise for 170 people with COPD. The goal is to see if this type of training improves heart and lung fitness, immune function, and quality of life better than standard care. Participants must have been in pulmonary rehab for at least 3…

This study is testing an inhaler called BGF 160 (also known as Breztri Aerosphere) in 35 adults with stable COPD. The goal is to see how the medicine changes the complexity and variability of breathing patterns over 30 days. Participants will use the inhaler twice daily, and rese…

This study tests a specialized clinic designed to diagnose and treat muscle loss (sarcopenia) in people with COPD. The clinic brings together a team of experts to provide targeted care. Researchers will see if this approach improves muscle mass and function, and reduces hospitali…

This study is testing whether a community-based exercise program can improve exercise capacity in 200 adults aged 18-85 with reduced heart or lung function. Participants will exercise 40-60 minutes, five times a week, for eight weeks, doing activities like brisk walking, jogging,…

This study is testing whether two simple breathing tests—oscillometry and FeNO—can help primary care doctors accurately diagnose asthma and COPD, compared to the usual specialist methods. Researchers will enroll 600 adults with suspected asthma or COPD across six countries. If th…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study aims to find people who have asthma or COPD but don't know it yet. Participants will take an online questionnaire to see if they are at risk. Those at risk will be randomly assigned to receive early diagnosis and treatment from their doctor or usual care. The goal is t…

This study tests whether a smartphone app (AWARE) can accurately detect and monitor lung diseases like asthma, COPD, and cystic fibrosis by analyzing sound waves from the phone's speaker and microphone. Researchers will enroll 800 people aged 8-70, including healthy volunteers an…

This study tests whether combining arm and leg endurance training is better than leg training alone for improving daily activities in people with COPD. 36 participants with moderate-to-severe COPD will undergo 14 supervised sessions. The main goal is to see if the combined traini…

This study tests whether a device called Airvo 3, which automatically adjusts oxygen levels, can keep COPD patients' blood oxygen in a healthy range better than manual adjustments by nurses. About 70 hospitalized adults with COPD and low oxygen will take part. The goal is to see …

This study looks at whether using a nasal high-flow device (which delivers warm, moist air at a high rate) can help people with COPD walk farther during a 6-minute walk test. Thirty adults with COPD will try both the high-flow device and a standard low-flow device on different da…

This study looks at whether people with COPD and chronic bronchitis who switch from regular cigarettes to a tobacco heating system feel better and breathe easier. About 290 adults aged 40 and older who have smoked for at least 10 years will take part. Researchers will measure cou…

This study tests whether three 15-minute hypnosis sessions can help people with persistent breathlessness from cancer, COPD, interstitial lung disease, or chronic heart failure feel more in control of their breathing. Researchers will measure changes using a standard questionnair…

This study compares two easy relaxation methods—Laura Mitchell's technique and Benson's relaxation response—in 38 adults aged 40–60 with moderate to severe COPD. Participants will practice one of the techniques for 15–20 minutes daily over 6 weeks. The goal is to see which method…

This study tests a small, hands-free device called PEP-buddy that creates gentle pressure when you breathe out. It is designed to quickly relieve sudden shortness of breath in people with COPD. Researchers will have 25 participants use the device for 4 weeks to measure if it redu…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study tests whether dronabinol, a synthetic form of THC (the psychoactive compound in cannabis), can reduce severe breathlessness in people with advanced COPD. Thirty participants will receive both dronabinol and a placebo in random order to compare effects. The goal is to s…

This study tests whether a 20-minute video call with a nurse, who teaches about oral hygiene, can improve mouth health in people with COPD. Researchers will compare oral health scores and quality of life between a group that gets the video call and a group that does not. The tria…

This early-stage study tests a new inhaled drug called HRS-9821 in 160 people. First, healthy volunteers get a single dose to check safety. Then, people with COPD receive multiple doses. The main goal is to see what side effects occur and how the drug moves through the body. This…

This study tests whether adding music to standard exercise training helps people with COPD and chronic respiratory failure improve their walking distance and feel less breathless. 156 participants will either do usual rehab or rehab while listening to music they choose (rock, mod…

This study tests whether a 12-week Coping Skills Training program can reduce depression and anxiety in 750 people with COPD, especially those facing health disparities like low income or rural living. Participants attend weekly sessions and complete surveys. The program is compar…

This study tests a remote program that combines walking with Tai Chi for veterans who have both COPD and long-term muscle or joint pain. The goal is to see if it helps them move better and feel less limited by their conditions. Researchers will track daily steps, pain levels, and…

This study compares two COPD self-management education programs: a self-guided booklet and a counselor-led phone program. Researchers want to see which approach better reduces hospitalizations and improves quality of life. 448 adults with COPD who have been hospitalized in the pa…

This study compares a new asymmetric nasal cannula (DUET) to a standard one in 50 people with mild-to-moderate COPD flare-ups and high carbon dioxide levels. Each participant will try both devices for 3 hours to see which lowers CO2 better, reduces breathing effort, and feels mor…

This study looks at how mucus plugs in the lungs affect breathing in people with severe asthma. Researchers will use special MRI scans to see air flow in blocked areas. Only 5 adults with severe asthma will take part, and the goal is to better understand lung function, not to tes…

This study looks at how well people with COPD understand health information and how that relates to their physical abilities, thinking skills, daily activities, and quality of life. Researchers will compare 144 adults with COPD to healthy volunteers using tests of walking, thinki…

This study will follow 500 adults with stable COPD for at least 3 years to identify and describe different patient profiles. Researchers will use routine care data to group patients by their characteristics, treatments, and outcomes. The goal is to better understand the various f…

This study aims to better understand asthma and COPD by comparing immune markers in blood and airways of patients versus healthy volunteers. Researchers will analyze samples from 230 adults to identify distinct immune patterns linked to disease severity. The goal is to improve di…

This study looks at why some smokers develop COPD while others don't. Researchers will collect lung cells from 40 former smokers using a bronchoscopy and analyze them to find differences in immune cells called macrophages. The goal is to understand the biological reasons behind C…

This observational study will follow 850 Chinese adults with COPD or pre-COPD for one year. Researchers will collect medical history, lung function tests, blood samples, and CT scans to identify different disease types and markers. The goal is to better understand how COPD develo…

This study looks at whether a short questionnaire called the COPD Assessment Test (CAT) can help predict breathing complications during and after surgery in people with COPD. Researchers will follow 120 patients aged 40-70 having elective surgery. They will compare those with low…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study is testing a digital tool that includes a spirometer and an app to help people with COPD monitor their lung function daily at home. The goal is to see if the tool is easy to use, safe, and helps patients know when to seek medical care. Fifty adults with COPD who have h…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study follows 20 people with severe emphysema who are scheduled to receive endobronchial valves. Researchers will measure how much oxygen patients use during everyday activities before and six months after the procedure. The goal is to see if the treatment reduces the physic…

This study tests a detailed half-day health assessment for people with COPD who have frequent flare-ups requiring steroid tablets. The assessment checks lung health, other conditions like heart disease, and lifestyle factors, then creates a personalized treatment plan. Researcher…

This study will check how many workers in an industrial zone in Thailand have asthma or COPD. About 310 adults will answer a questionnaire and take a breathing test. The goal is to find out how common these lung problems are in this group, not to test a treatment.

This study is creating a Turkish version of a questionnaire that helps find breathing pattern problems in people with COPD. Researchers will test the questionnaire on 90 stable COPD patients to make sure it works well. The goal is to give doctors a better tool to understand and t…

This study looks at how walking, strength training, and breathing exercises change oxygen levels in the brain and leg muscles of people with moderate-to-severe COPD. Researchers will compare 60 participants (30 with COPD and 30 healthy adults) using special light-based sensors. T…

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study is creating a registry of 420 people who are already getting lung cancer screening and may have COPD. Researchers will collect information like breathing tests, CT scans, and symptoms to better understand COPD in this group. The goal is to improve how COPD is found and…

This study aims to develop a noninvasive way to detect blood vessel changes in the lungs of people with Group 3 pulmonary hypertension (PH) using a special MRI technique. Researchers will compare MRI results with lung tissue from 30 patients awaiting lung transplant. The goal is …

This study follows 25 people with COPD and high carbon dioxide levels who use a breathing machine at night. Researchers want to see if nighttime breathing problems can predict how well the machine works over 6 to 12 months. They will also check lung function, diaphragm health, an…

This study looks at why people with COPD may have overactive nerve signals that increase heart rate and narrow blood vessels. Researchers will measure nerve activity, breathing, and inflammation in 135 adults with COPD. The goal is to better understand the causes, not to test a n…

This study looks at how the diaphragm, the main muscle used for breathing, works in people with lung diseases like asthma, COPD, fibrosis, and pulmonary hypertension. Researchers want to see if diaphragm problems are linked to shortness of breath. About 800 adults will take breat…

This study looks at whether simple measurements—like thigh circumference and muscle stiffness—can reliably track muscle health in people with COPD. Researchers will measure 30 patients before and after a pulmonary rehabilitation program. The goal is to find an easy way to monitor…

This study looks at how air pollution particles get into the bodies of non-smokers with lung cancer, COPD, or leukemia, and compares them to healthy volunteers. Researchers will use advanced microscopes and chemical tests to find these particles in blood and tissue samples. The g…

This study looks at whether an ultrasound measurement of the diaphragm can help predict which patients hospitalized with a COPD flare-up will get worse and need breathing support or die. About 186 adults with severe COPD will have an extra ultrasound during their hospital stay. T…

This study compares muscle strength, exercise ability, and oxygen use in 60 people with COPD, a condition called PRISm (which is like early-stage COPD), and healthy volunteers. Researchers will measure breathing muscle strength, arm and leg strength, and how well muscles use oxyg…

This study aims to understand why some people with alpha-1 antitrypsin deficiency (AATD) get more respiratory infections. Researchers will compare immune responses to a pneumonia vaccine (PCV20) in 30 adults who carry one abnormal copy of the SERPINA1 gene. Half have had frequent…

This study is building a registry of genetic and health information from 3,000 people with conditions like diabetes, high cholesterol, cancer, and heart disease. The goal is to help doctors choose the safest and most effective medications based on a person's genetic makeup. Parti…

This study follows 100 adults with COPD for one year to see how airway inflammation changes over time. Researchers use a simple breath test (FeNO) and a blood sample to measure inflammation markers. Participants visit the clinic three times—at the start, 6 months, and 12 months—t…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study follows 730 adults with COPD who still have severe shortness of breath even after using standard inhalers. Researchers will track their health over time to see what factors lead to more flare-ups, faster lung decline, or death. The goal is to better understand this dif…