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Cuff-Based exercise may offer safer workouts for lung disease patients

NCT ID NCT05163600

Knowledge-focused Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study investigates how exercising with blood-flow restriction (using thigh cuffs) affects breathing and blood pressure compared to traditional exercise. Researchers will test healthy adults and people with COPD to see if this approach reduces strain on the heart and lungs. The goal is to understand whether blood-flow restricted exercise could be a safer alternative for those with respiratory limitations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
blood-flow restriction exercise
What this could lead to
If successful, this could point toward safer, more effective exercise programs for people with COPD.
What could go wrong
This is a small, early-stage study focused on acute responses, not long-term outcomes. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion and exclusion for the healthy participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Clinically healthy Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg Inclusion and exclusion for the COPD participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Diagnosed COPD according to GOLD-guidelines12 Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Acute or recent (within the last 6 weeks) exacerbation of COPD * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University Hospital Zürich

    RECRUITING

    Zurich, Canton of Zurich, 8091, Switzerland

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