New implant aims to release trapped air in lungs of COPD patients

NCT ID NCT06891755

Recruiting now Disease control Sponsor: Apreo Health, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a permanent implant called the Apreo BREATHE Airway Scaffold in up to 250 adults with COPD and emphysema who still feel short of breath despite standard treatments. The implant is designed to prop open airways and release trapped air to improve breathing. Researchers will check if the procedure is safe and if it helps lung function over 3 years.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD EMPHYSEMA

Contacts and locations

Locations

Banner Health
RECRUITING

Gilbert, Arizona, 85234, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44103, United States
Clinical Research Associates of Central Pennsylvania
RECRUITING

DuBois, Pennsylvania, 15801, United States
Houston Methodist/Primary Critical Care
RECRUITING

Houston, Texas, 77030, United States
Inova Health Care Services
RECRUITING

Falls Church, Virginia, 22042, United States
Karl Landsteiner Institute - Klink Floridsdorf
RECRUITING

Vienna, A-1210, Austria
Mayo Clinic
RECRUITING

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
OSF St Francis Medical Center
RECRUITING

Peoria, Illinois, 61637, United States
Orlando Health
RECRUITING

Orlando, Florida, 32806, United States
Royal Brompton Hospital
RECRUITING

London, SW36JY, United Kingdom
St. Bartholomew's Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
Temple University
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
University Medical Center Groningen
RECRUITING

Groningen, 9713 GZ, Netherlands
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
University of California at Davis
RECRUITING

Sacramento, California, 95817, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Kansas Medical Center Research Institute
RECRUITING

Kansas City, Kansas, 66160, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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