Can scientists unlock the secrets of breathing muscle failure in severe COPD?
NCT ID NCT06935825
First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time
Summary
This study investigates why breathing muscles weaken in people with end-stage COPD, a severe lung disease. Researchers will measure muscle function using non-invasive tests like ultrasound and EMG, and analyze muscle tissue samples taken during lung transplant surgery. The goal is to understand the underlying processes and how treatments like non-invasive ventilation affect these muscles. Sixty adults on the lung transplant waiting list will participate.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this research could uncover why respiratory muscles weaken in severe COPD and how treatments like ventilation or transplant affect them, potentially guiding better therapies.
- What could go wrong
- This is an early exploratory study with only 60 participants, so findings may not apply broadly. It observes rather than tests a treatment, so no direct benefit for participants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for COPD are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Amsterdam University Medical Center
NOT_YET_RECRUITINGAmsterdam, Netherlands
Contact Email: •••••@•••••
-
Erasmus Medical Center
RECRUITINGRotterdam, Netherlands
Contact Email: •••••@•••••
-
Radboud University Medical Center
NOT_YET_RECRUITINGNijmegen, Netherlands
Contact Email: •••••@•••••
-
University Medical Center Groningen
RECRUITINGGroningen, Netherlands
Contact
Contact Email: •••••@•••••
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A handheld device that vibrates the airways may help COPD patients breathe easier
- Which exercise is better for the COPD brain? scientists compare steady vs. burst workouts
- Your voice could hold the key to spotting lung disease
- Blood tests could unlock early clues for three major lung diseases
- Could a 7-Day antibiotic course be as effective as 14 days for COPD attacks?
- Tiny activity 'Snacks' may sharpen minds in COPD