New Two-Step valve procedure aims to cut lung collapse risk in emphysema patients
NCT ID NCT06181357
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the valve placement over two sessions, which early studies suggest may lower that risk to between 4.5% and 12%. The trial will enroll 244 adults aged 35–80 with severe emphysema who have quit smoking, and will track pneumothorax rates and lung function over 45 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Zephyr endobronchial valves
What this could lead to
If successful, this two-stage procedure could lower the risk of lung collapse (pneumothorax) after valve placement, making treatment safer for people with severe emphysema.
What could go wrong
This is a relatively small trial (244 people) and has not yet been compared directly to the standard method. The two-stage approach requires two procedures, which may still carry risks and might not prove superior.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Email: •••••@•••••
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Locations
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APHM
RECRUITINGMarseille, 13000, France
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APHP
RECRUITINGParis, 75018, France
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APHP
NOT_YET_RECRUITINGParis, 78014, France
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CHU de Bordeaux
RECRUITINGBordeaux, 33000, France
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CHU de Brest
RECRUITINGBrest, 29000, France
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CHU de Dijon
RECRUITINGDijon, 21000, France
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CHU de Lille
RECRUITINGLille, 59000, France
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CHU de Limoges
RECRUITINGLimoges, 87000, France
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CHU de Nice
NOT_YET_RECRUITINGNice, 06000, France
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CHU de Rouen
NOT_YET_RECRUITINGRouen, 76000, France
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Groupe Hospitalier Est - HCL
NOT_YET_RECRUITINGBron, 69500, France
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Hopital Foch
RECRUITINGSuresnes, 92150, France
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Hopital Saint Joseph
RECRUITINGMarseille, 13000, France
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Hopital privé de la loire
RECRUITINGSaint-Etienne, 42000, France
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chu de Grenoble
RECRUITINGGrenoble, 38000, France
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chu de Strasbourg
RECRUITINGStrasbourg, 67000, France
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chu de Toulouse
RECRUITINGToulouse, 31000, France
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