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New Two-Step valve procedure aims to cut lung collapse risk in emphysema patients

NCT ID NCT06181357

Recruiting now Disease control Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the valve placement over two sessions, which early studies suggest may lower that risk to between 4.5% and 12%. The trial will enroll 244 adults aged 35–80 with severe emphysema who have quit smoking, and will track pneumothorax rates and lung function over 45 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Zephyr endobronchial valves
What this could lead to
If successful, this two-stage procedure could lower the risk of lung collapse (pneumothorax) after valve placement, making treatment safer for people with severe emphysema.
What could go wrong
This is a relatively small trial (244 people) and has not yet been compared directly to the standard method. The two-stage approach requires two procedures, which may still carry risks and might not prove superior.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease COPD, severe early onset pneumothorax pulmonary emphysema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COPD

Contacts and locations

Locations

  • APHM

    RECRUITING

    Marseille, 13000, France

  • APHP

    RECRUITING

    Paris, 75018, France

  • APHP

    NOT_YET_RECRUITING

    Paris, 78014, France

  • CHU de Bordeaux

    RECRUITING

    Bordeaux, 33000, France

  • CHU de Brest

    RECRUITING

    Brest, 29000, France

  • CHU de Dijon

    RECRUITING

    Dijon, 21000, France

  • CHU de Lille

    RECRUITING

    Lille, 59000, France

  • CHU de Limoges

    RECRUITING

    Limoges, 87000, France

  • CHU de Nice

    NOT_YET_RECRUITING

    Nice, 06000, France

  • CHU de Rouen

    NOT_YET_RECRUITING

    Rouen, 76000, France

  • Groupe Hospitalier Est - HCL

    NOT_YET_RECRUITING

    Bron, 69500, France

  • Hopital Foch

    RECRUITING

    Suresnes, 92150, France

  • Hopital Saint Joseph

    RECRUITING

    Marseille, 13000, France

  • Hopital privé de la loire

    RECRUITING

    Saint-Etienne, 42000, France

  • chu de Grenoble

    RECRUITING

    Grenoble, 38000, France

  • chu de Strasbourg

    RECRUITING

    Strasbourg, 67000, France

  • chu de Toulouse

    RECRUITING

    Toulouse, 31000, France

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