Pneumothorax

This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the v…

This trial tests two ways of using a breathing machine during surgery in 200 adults at high risk for lung complications. One method uses standard protective settings, while the other adjusts the machine based on each patient's lung stiffness. Researchers will track lung problems,…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study tests a new method to find air leaks in the lungs during surgery. Doctors blow a visible glycerine smoke into the lungs, and the smoke escapes through any leaks, making them easy to spot. The goal is to reduce complications and hospital stays for 200 lung transplant pa…

This study uses donated human lungs to test a new method for detecting and sealing air leaks that can happen during lung surgery. Researchers will place the lungs in a special box, keep them warm, and use a video camera and a bio-adhesive to find and fix leaks. The goal is to red…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study tests a new, reusable gas analyzer that attaches to chest drains to detect air leaks after lung surgery. The device measures carbon dioxide, oxygen, and pressure to identify leaks, potentially improving accuracy over the current method of watching for bubbles. About 33…

This study tests whether a smaller 16F chest drain causes less pain than the standard 24F drain after minimally invasive lung surgery. About 124 adults having a lung lobe or segment removed will be randomly assigned to one drain size. Pain levels while coughing will be measured o…

This study tests whether a digital chest tube system (Thopaz+) works better than the standard analog system for children who need a chest tube after lung surgery or a collapsed lung. The digital system measures air leaks precisely and keeps steady suction, which may shorten how l…

This study is testing whether a safe, non-invasive brain stimulation technique called rTMS can help people with frontotemporal dementia (FTLD) or those at risk. 120 participants will receive either real or placebo stimulation for 2 weeks, then all will get real stimulation. Resea…

This study aims to understand how lymphangioleiomyomatosis (LAM) damages the lungs at the cellular and genetic level. Researchers will follow up to 2,000 participants, including women with LAM and healthy volunteers, using advanced imaging and lab tests. The goal is to find the p…

This study looks at a rare inherited condition called Birt-Hogg-Dube (BHD) syndrome, which raises the risk of kidney cancer. Researchers will collect blood, saliva, and tissue samples from up to 950 participants to find the genes involved and understand how kidney tumors grow. Th…

This study looks at two common methods for managing chest tubes in people with blood or air in the chest after an injury. About 150 adults will be assigned to either suction or water seal to see which method leads to shorter chest tube use and fewer problems. The goal is to find …

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at whether measurements from a ventilator during lung surgery can predict air leaks after the operation. Air leaks are common after lung removal and often require painful drains. The researchers will compare ventilator readings with actual leak amounts in 100 pat…

This study looks at whether analyzing stomach fluid from newborns can predict if they will need breathing support for more than 6 hours after birth. Researchers will enroll 500 babies born at 32 weeks or later in a lower-level NICU. The goal is to see if a new algorithm can accur…

This study tests whether an AI tool called LuAna helps doctors find lung problems in chest X-rays more accurately than doctors working alone. About 1,470 adults with breathing issues will have their X-rays read first by doctors, then with AI support. The goal is to see if AI boos…

This study tests whether injecting a small amount of salt water into the space around the lung during a CT-guided lung biopsy can lower the chance of a pneumothorax (collapsed lung). Researchers will also position patients so the biopsy targets gravity-dependent areas. About 198 …

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants …

This study explores whether medical trainees (residents and fellows) can learn to use lung ultrasound to detect a collapsed lung (pneumothorax) after heart surgery. About 120 adults will have their lungs checked by a trainee with ultrasound and also get a standard chest X-ray aft…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …