Pleural disorder

This phase II trial is testing whether giving two immunotherapy drugs, nivolumab and ipilimumab, before surgery can help control sarcomatoid mesothelioma, a rare and aggressive cancer of the lung lining. The study will enroll 26 people with stage I to IIIa disease. The main goals…

This phase 3 trial tests whether early irrigation of the chest cavity with saline can improve outcomes for people with complicated pleural infections. 244 adults will receive either standard care or saline irrigation twice daily for three days. The goal is to see if this approach…

This study tests two different drug combinations for pleural infection, a serious infection of the lung lining that often requires surgery. The standard treatment uses two drugs (alteplase and DNase) given through a chest tube. This trial compares that to a new combination using …

This early-phase trial is testing an experimental drug called BMS-986504 alongside standard cancer treatments in 60 people with advanced cancers that have lost a gene called MTAP. The cancers include mesothelioma, stomach/esophageal cancer, and bladder cancer. The main goal is to…

This study compares two ways of placing Zephyr valves in the lungs of people with severe emphysema (a type of COPD). The standard method treats the entire lobe in one session, but about 27% of patients develop a collapsed lung (pneumothorax). The experimental method spreads the v…

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This pilot study tests whether the steroid prednisone can prevent recurrent pleural effusions (fluid buildup around the lungs) in people with non-specific pleuritis. Forty adults will be randomly assigned to take prednisone daily for 4 weeks or receive no steroid. The study lasts…

This early-stage trial tests an experimental drug called SAR445877, alone or with other cancer drugs, in adults with advanced solid tumors that have spread or cannot be removed. The study has two parts: first, finding a safe dose, and second, checking if the drug shrinks tumors. …

This early-phase study tests a new drug called CT-95 in people with advanced cancers that have a protein called mesothelin on their cells. The main goals are to find a safe dose and see if the drug can shrink tumors. About 70 adults with ovarian, lung, pancreatic, or other mesoth…

This early-phase trial is testing whether adding an immunotherapy drug (atezolizumab) and a personalized vaccine (WT1/DC) to standard chemotherapy can safely improve outcomes for people with a rare type of mesothelioma. The study plans to enroll 15 adults with epithelioid maligna…

This study tests a drug called sacituzumab govitecan in 33 adults with mesothelioma that has come back or spread. Participants receive the drug until their disease worsens or side effects become too severe. The main goal is to see if the drug can shrink tumors and help control th…

This phase 2 trial is testing an experimental drug called volrustomig, either alone or with chemotherapy, in people with advanced cervical, head and neck, esophageal, or mesothelioma cancers. The study aims to see if the drug can shrink tumors and how safe it is. About 257 partic…

This study is testing a precise type of radiation called IMPRINT for people whose thymic cancer has spread to the lining of the lung (pleura). The main goal is to see if this treatment is safe and causes only mild side effects, especially lung inflammation. About 36 participants …

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, and liver cancers. The trial has two parts: first, finding a safe dose (p…

This early-phase trial tests a new treatment for people with mesothelioma that cannot be removed by surgery or has come back after standard therapy. The treatment uses donor immune cells (natural killer cells) that are engineered in a lab to recognize and attack two proteins foun…

This study tests whether proton beam therapy can help people with a rare cancer called malignant pleural mesothelioma. It involves 148 adults whose cancer is on one side of the chest. The goal is to see if this treatment can slow the cancer and help people live longer with fewer …

This phase 2 trial tests a drug called ivonescimab in 38 people with pleural mesothelioma whose cancer has returned after immunotherapy and chemotherapy. The drug works by blocking blood vessel growth and boosting the immune system to fight cancer. The main goal is to see if the …

This study tests a procedure called chemoembolization for people with non-small cell lung cancer or lung tumors that have spread from other cancers. Doctors inject chemotherapy directly into the artery feeding the tumor and then block that artery with tiny beads. This traps the c…

This study tests a new treatment using specially engineered immune cells (called CAR-NK cells) from donated cord blood, given alongside chemotherapy, for people with advanced kidney cancer, mesothelioma, or bone cancer. The goal is to find a safe dose and see if it helps control …

This trial tests two ways of using a breathing machine during surgery in 200 adults at high risk for lung complications. One method uses standard protective settings, while the other adjusts the machine based on each patient's lung stiffness. Researchers will track lung problems,…

This study tests whether washing the chest cavity with the antifungal drug voriconazole can help treat a rare but serious fungal infection of the lung lining. It includes 50 patients who either get the wash before surgery or as a standalone treatment if they are too sick for surg…

This early-phase trial tests whether adding the immunotherapy drug pembrolizumab and a special imaging technique during surgery can improve treatment for malignant pleural mesothelioma, a rare and aggressive lung cancer. About 20 adults with measurable disease will receive the co…

This study tests whether treating pleural empyema (a serious lung infection with pus in the chest cavity) with a drain and medication works as well as surgery. 184 adults with advanced-stage empyema will be randomly assigned to either video-assisted surgery or a less invasive app…

This study tests whether giving immunotherapy drugs (durvalumab and tremelimumab) alone or with chemotherapy before surgery can help prevent pleural mesothelioma from coming back. About 52 people with potentially removable tumors will take part. The main goal is to see if more th…

This study tests a new two-step treatment for people with malignant pleural mesothelioma, a rare and serious cancer of the lung lining. First, doctors use a special light therapy during a scope procedure to kill cancer cells. Then, patients receive an immunotherapy drug called ni…

This early-stage trial tests a new drug called NX-1607 in adults with advanced cancers that have not responded to standard treatments. The study aims to find a safe dose and see if the drug can shrink tumors. It includes people with several cancer types, such as ovarian, lung, an…

This study is testing a new ultrasound measurement called the Lung Sliding Index (LSI) to see if it can help doctors tell apart different lung diseases, such as COPD, pneumonia, and pulmonary edema. Researchers will measure LSI in 700 adults with various lung conditions and healt…

This study tests whether using a special microscope (confocal laser endomicroscopy) during a chest camera procedure can better diagnose unexplained pleural disease. About 158 adults with fluid around the lungs that standard tests couldn't diagnose will be randomly assigned to get…

This study is testing a new laboratory method that looks for DNA fragments from tuberculosis bacteria in fluid around the lungs (pleural effusion). The goal is to see if this test can diagnose tuberculous pleurisy more accurately than current tests. Researchers will study 400 adu…

This study tests a new method to find air leaks in the lungs during surgery. Doctors blow a visible glycerine smoke into the lungs, and the smoke escapes through any leaks, making them easy to spot. The goal is to reduce complications and hospital stays for 200 lung transplant pa…

This study uses donated human lungs to test a new method for detecting and sealing air leaks that can happen during lung surgery. Researchers will place the lungs in a special box, keep them warm, and use a video camera and a bio-adhesive to find and fix leaks. The goal is to red…

This study is testing a new platform that uses advanced testing to get a complete picture of a person's tumor. The goal is to see if this detailed information can help doctors choose better treatments for patients with high-risk cancers like leukemia, multiple myeloma, and pancre…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study is testing a new breath test, called an electronic nose (E-Nose), to see if it can measure how well treatment is working for people with malignant pleural mesothelioma (MPM). Researchers will collect breath samples from 20 patients before and during standard treatment,…

This study tests a new, reusable gas analyzer that attaches to chest drains to detect air leaks after lung surgery. The device measures carbon dioxide, oxygen, and pressure to identify leaks, potentially improving accuracy over the current method of watching for bubbles. About 33…

This study tests whether giving medication once a day through a chest tube works as well as giving it twice a day for people with serious infections around the lungs. Participants are adults already in the hospital with a chest tube draining infected fluid. They will be randomly …

This study tests whether a smaller 16F chest drain causes less pain than the standard 24F drain after minimally invasive lung surgery. About 124 adults having a lung lobe or segment removed will be randomly assigned to one drain size. Pain levels while coughing will be measured o…

This study looks at whether adding a simple saltwater rinse (saline irrigation) through a chest tube can improve how well the standard medication clears a serious lung infection called empyema. About 60 adults with this infection will receive either standard treatment alone or st…

This study tests whether a digital chest tube system (Thopaz+) works better than the standard analog system for children who need a chest tube after lung surgery or a collapsed lung. The digital system measures air leaks precisely and keeps steady suction, which may shorten how l…

This study looks at two ways to treat malignant pleural effusion, a buildup of fluid in the lungs caused by cancer. One uses a small tube (indwelling pleural catheter) to drain fluid; the other adds the antibiotic doxycycline to help seal the lung. Researchers want to see if addi…

This study looks at whether regularly flushing chest drains with salt water helps keep them from getting blocked in people with serious lung infections (empyema). The goal is to see if this simple step can shorten the time the drain needs to stay in, reduce hospital stays, and im…

This study looks at whether a surgery called partial pleurectomy (removing part of the lung lining) can help with symptoms and quality of life in people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and fill out sympt…

This study tests whether a lower dose (2.5 mg) of a clot-busting drug called tPA works as well as the standard dose (10 mg) for treating pleural infections, which cause fluid buildup around the lungs. The drug is given through a chest tube along with another enzyme to help drain …

This study is testing whether a safe, non-invasive brain stimulation technique called rTMS can help people with frontotemporal dementia (FTLD) or those at risk. 120 participants will receive either real or placebo stimulation for 2 weeks, then all will get real stimulation. Resea…

This study aims to collect tumor, normal tissue, and blood samples from up to 1559 people with cancers of the lung, esophagus, or pleura. Researchers will analyze genetic and epigenetic changes to better understand these diseases and identify potential markers for future treatmen…

This study aims to understand how lymphangioleiomyomatosis (LAM) damages the lungs at the cellular and genetic level. Researchers will follow up to 2,000 participants, including women with LAM and healthy volunteers, using advanced imaging and lab tests. The goal is to find the p…

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study looks at a rare inherited condition called Birt-Hogg-Dube (BHD) syndrome, which raises the risk of kidney cancer. Researchers will collect blood, saliva, and tissue samples from up to 950 participants to find the genes involved and understand how kidney tumors grow. Th…

This study looks at how different types of mycobacterial infections, including drug-resistant tuberculosis and nontuberculous mycobacteria, change the body's immune response. Researchers will collect blood and other samples from 120 participants, including healthy people and thos…

This study looks at two common methods for managing chest tubes in people with blood or air in the chest after an injury. About 150 adults will be assigned to either suction or water seal to see which method leads to shorter chest tube use and fewer problems. The goal is to find …

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This research study is collecting tissue samples from 240 adults with malignant pleural mesothelioma to test a new method that combines molecular, radiological, and blood tests. The goal is to create a score that helps doctors predict how the disease will progress. Participants m…

This study looks at the immune system inside malignant pleural mesothelioma, a rare and hard-to-treat cancer. Researchers will analyze tumor samples from 300 adults to understand why immunotherapy helps only some patients. The goal is to find clues that could make these treatment…

This study looks at whether measurements from a ventilator during lung surgery can predict air leaks after the operation. Air leaks are common after lung removal and often require painful drains. The researchers will compare ventilator readings with actual leak amounts in 100 pat…

This study looks at whether analyzing stomach fluid from newborns can predict if they will need breathing support for more than 6 hours after birth. Researchers will enroll 500 babies born at 32 weeks or later in a lower-level NICU. The goal is to see if a new algorithm can accur…

This study tests whether an AI tool called LuAna helps doctors find lung problems in chest X-rays more accurately than doctors working alone. About 1,470 adults with breathing issues will have their X-rays read first by doctors, then with AI support. The goal is to see if AI boos…

This study tests whether injecting a small amount of salt water into the space around the lung during a CT-guided lung biopsy can lower the chance of a pneumothorax (collapsed lung). Researchers will also position patients so the biopsy targets gravity-dependent areas. About 198 …

This study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants …

This study explores whether medical trainees (residents and fellows) can learn to use lung ultrasound to detect a collapsed lung (pneumothorax) after heart surgery. About 120 adults will have their lungs checked by a trainee with ultrasound and also get a standard chest X-ray aft…

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study is looking at tumor samples from 220 people with pleural or peritoneal mesothelioma, a rare cancer linked to asbestos. Researchers will analyze the genes and immune cells in these tumors to find patterns that could predict which treatments work best. The goal is to imp…