New drug combo aims to stall rare lung cancer
NCT ID NCT07234058
First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times
Summary
This study tests whether adding an experimental immunotherapy (fianlimab) to standard treatment (cemiplimab plus chemotherapy) can better control pleural mesothelioma, a rare and aggressive cancer of the lung lining. About 126 people who have not yet been treated will receive one of two drug combinations. The goal is to see if the disease stays stable or shrinks for at least 6 months. This is not a cure; treatment continues as long as it works or up to 2 years.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Aix-Pertuis - CHI
NOT_YET_RECRUITINGAix-en-Provence, France
Contact Email: •••••@•••••
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Amiens - CHU
NOT_YET_RECRUITINGAmiens, France
Contact Email: •••••@•••••
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Angers - CHU
NOT_YET_RECRUITINGAngers, France
Contact Email: •••••@•••••
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Avignon - CH
NOT_YET_RECRUITINGAvignon, France
Contact Email: •••••@•••••
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Besançon - CHU
NOT_YET_RECRUITINGBesançon, 75009, France
Contact Email: •••••@•••••
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Bordeaux - CHU
NOT_YET_RECRUITINGPessac, France
Contact Email: •••••@•••••
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Bordeaux - Institut Bergonié
NOT_YET_RECRUITINGBordeaux, France
Contact Email: •••••@•••••
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Boulogne - APHP Ambroise Paré
RECRUITINGBoulogne-Billancourt, France
Contact Email: •••••@•••••
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Caen - CHU
NOT_YET_RECRUITINGCaen, France
Contact Email: •••••@•••••
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Clermont-Ferrand - CHU
NOT_YET_RECRUITINGClermont-Ferrand, France
Contact Email: •••••@•••••
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Clermont-Ferrand - Centre Jean Perrin
NOT_YET_RECRUITINGClermont-Ferrand, France
Contact Email: •••••@•••••
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Créteil - CHI
NOT_YET_RECRUITINGCréteil, France
Contact Email: •••••@•••••
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Dijon - Centre Georges-François Leclerc
NOT_YET_RECRUITINGDijon, France
Contact Email: •••••@•••••
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Grenoble - CHU
NOT_YET_RECRUITINGGrenoble, France
Contact Email: •••••@•••••
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La Roche-Sur-Yon - CHD Vendée
NOT_YET_RECRUITINGLa Roche-sur-Yon, France
Contact Email: •••••@•••••
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Le Mans - CHG
NOT_YET_RECRUITINGLe Mans, France
Contact Email: •••••@•••••
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Lille - CHU
RECRUITINGLille, France
Contact Email: •••••@•••••
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Lyon - HCL
NOT_YET_RECRUITINGPierre-Bénite, France
Contact Email: •••••@•••••
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Marseille - APHM Nord
NOT_YET_RECRUITINGMarseille, France
Contact Email: •••••@•••••
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Marseille - Hôpital Européen
NOT_YET_RECRUITINGMarseille, France
Contact Email: •••••@•••••
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Montpellier - CHU
NOT_YET_RECRUITINGMontpellier, France
Contact Email: •••••@•••••
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Mulhouse - GHRMSA
NOT_YET_RECRUITINGMulhouse, France
Contact Email: •••••@•••••
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Nantes - Hôpital Laennec
RECRUITINGNantes, France
Contact Email: •••••@•••••
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Nantes - Institut de Cancérologie de l'Ouest
NOT_YET_RECRUITINGSaint-Herblain, 75009, France
Contact Email: •••••@•••••
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Paris - APHP Bichat
RECRUITINGParis, France
Contact Email: •••••@•••••
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Paris - APHP Cochin
NOT_YET_RECRUITINGParis, France
Contact Email: •••••@•••••
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Reims - Institut Godinot
RECRUITINGReims, France
Contact Email: •••••@•••••
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Rennes - CHU
NOT_YET_RECRUITINGRennes, France
Contact Email: •••••@•••••
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Saint-Nazaire - Clinique Mutualiste de l'Estuaire
NOT_YET_RECRUITINGSaint-Nazaire, France
Contact Email: •••••@•••••
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Strasbourg - Nouvel Hôpital Civil
RECRUITINGStrasbourg, 75009, France
Contact Email: •••••@•••••
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Toulon - CHI
RECRUITINGToulon, France
Contact Email: •••••@•••••
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Toulon - Sainte Anne HIA
NOT_YET_RECRUITINGToulon, France
Contact Email: •••••@•••••
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Toulouse - CHU
RECRUITINGToulouse, France
Contact Email: •••••@•••••
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Tours - CHU
RECRUITINGTours, 75009, France
Contact Email: •••••@•••••
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Vandoeuvre-lès-Nancy - Institut de Cancérologie de Lorraine
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, France
Contact Email: •••••@•••••
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Villefranche sur Saône - CH
NOT_YET_RECRUITINGVillefranche-sur-Saône, France
Contact Email: •••••@•••••
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Villejuif - Gustave Roussy
NOT_YET_RECRUITINGVillejuif, France
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Chest-Injected drug drain Cancer's fluid trap?
- Can a pill that blocks multiple cancer proteins shrink Hard-to-Treat tumors?
- Triple-Drug cocktail targets Hard-to-Treat mesothelioma
- New antibody-chemo combo shows promise for mesothelioma
- Triple threat: new combo tackles rare lung cancer
- Immunotherapy before surgery shows promise for mesothelioma patients