Triple-Drug cocktail targets Hard-to-Treat mesothelioma
NCT ID NCT06318286
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a combination of three types of drugs—an immunotherapy (pembrolizumab), a targeted therapy (lenvatinib), and chemotherapy (pemetrexed plus cisplatin or carboplatin)—as a first treatment for people with advanced malignant pleural mesothelioma that cannot be removed by surgery. The study aims to see how well this combination shrinks tumors and how safe it is. About 25 participants will receive the drugs in cycles, followed by maintenance therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pembrolizumab, lenvatinib, pemetrexed, and cisplatin or carboplatin
What this could lead to
If successful, this combination could offer a new first-line treatment option for people with advanced malignant pleural mesothelioma, potentially improving tumor shrinkage and delaying disease progression.
What could go wrong
This is a small, early-phase trial with only 25 participants, so results may not apply broadly. The combination of multiple drugs also raises the risk of significant side effects.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hyogo Medical University Hospital
Nishinomiya, Hyōgo, 6638501, Japan