Can a Chest-Injected drug drain Cancer's fluid trap?

NCT ID NCT05278975

Completed Disease control Sponsor: RS Oncology LLC Source: ClinicalTrials.gov ↗

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that the drug can control the fluid and shrink tumors. About 50 adults with specific cancers, including mesothelioma, breast, ovarian, or lung cancer, are taking part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental drug called RSO-021 (thiostrepton) given directly into the chest cavity
What this could lead to: If it works, this could offer a new way to control fluid buildup in the chest caused by advanced cancers, potentially improving breathing and quality of life.
What could go wrong: This is an early-phase trial with only 50 participants, so the drug may not prove safe or effective. Side effects from direct chest administration are possible.

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Conditions

The condition(s) this trial relates to.

breast cancer malignant pleural mesothelioma mesothelioma Mesothelioma, Malignant non-small cell lung carcinoma ovarian cancer Pleural Effusion, Malignant pleural mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALIGNANT PLEURAL EFFUSION MALIGNANT PLEURAL MESOTHELIOMA MESOTHELIOMA MESOTHELIOMA; LUNG MESOTHELIOMAS PLEURAL PLEURAL EFFUSION, MALIGNANT

Contacts and locations

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Locations

Barts Health NHS Cancer Institute

London, EC1A7BE, United Kingdom
Facility: HOPE Clinical Trials Facility, Leicester Royal Infirmary

Leicester, LE1 5WW, United Kingdom
Guys and St Thomas NHS Foundation Trust

London, SE19RT, United Kingdom
Leeds Teaching Hospital

Leeds, Leeds, LS970F, United Kingdom
NHS Greater Glasgow & Clyde

Glasgow, United Kingdom
Northumbria NorthTyne Side General Hospital

North Shields, North Shields, NE29 8NH, United Kingdom
Oxford University Hospitals NHS Foundation

Oxford, OX42PG, United Kingdom
South Mead North Bristol Hopsital

Bristol, Bristol, BS105NB, United Kingdom
The Christie NHS

Manchester, M204BX, United Kingdom
The Royal Marsden

London, SW3 6JJ, United Kingdom

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