Can a pill that blocks multiple cancer proteins shrink Hard-to-Treat tumors?
NCT ID NCT03917043
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This early-phase trial is testing an experimental oral drug called APG-2449 in people with advanced solid tumors, including certain lung cancers, mesothelioma, esophageal cancer, and ovarian cancer. APG-2449 is designed to block several proteins (FAK, ALK, and ROS1) that help cancer cells grow. The study aims to find the safest dose and understand how the drug moves through the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- an experimental oral drug called APG-2449, a multi-targeted tyrosine kinase inhibitor that blocks FAK, ALK, and ROS1 proteins
- What this could lead to
- If it works, this could point toward a new treatment option for certain advanced solid tumors, especially lung cancers with specific gene changes.
- What could go wrong
- This is an early phase 1 trial, so the drug may not work as hoped or could cause unexpected side effects. The safe dose and effectiveness are still unknown.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Email: •••••@•••••
Contact
Contact Email: •••••@•••••
Contact
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Fujian Cancer Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, 350014, China
Contact
Contact
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Fujian Medical University Union Hospital
NOT_YET_RECRUITINGFuzhou, Fujian, 350001, China
Contact
Contact
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Henan Provincial Oncology Hospital
RECRUITINGZhengzhou, Henan, China
Contact
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Hunan Provincial Oncology Hospital
RECRUITINGChangsha, Hunan, China
Contact
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Sun-Yat Sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First affiliated hospital, Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, China
Contact
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Union Hospital medical college Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
Contact
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Zhejiang Provincial Oncology Hospital
RECRUITINGHangzhou, Zhejiang, China
Contact
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