Pleural disorder

This pilot study will test whether flushing the chest tube with saline alone can treat complicated pleural infections (fluid buildup around the lungs). If saline doesn't work, patients will receive stronger clot-busting drugs (fibrinolytics) or surgery. The study will track how l…

The PROMPT study is testing whether an early keyhole procedure called medical thoracoscopy works better than current standard treatment (medicines to break up thick fluid) for people with pleural infection. About 170 patients will be randomly assigned to one of the two treatments…

This study tests whether adding an experimental immunotherapy (fianlimab) to standard treatment (cemiplimab plus chemotherapy) can better control pleural mesothelioma, a rare and aggressive cancer of the lung lining. About 126 people who have not yet been treated will receive one…

This study compares two approaches for treating a large primary spontaneous pneumothorax (collapsed lung) in stable adults: active observation (monitoring without an invasive procedure) versus standard chest tube drainage. About 436 participants will be randomly assigned to one o…

This study tests a new drug called CVL006 combined with standard chemotherapy or other targeted drugs in people with advanced solid tumors that have not responded to previous treatments. The trial has two phases: first, to find the safest dose, and second, to see if the combinati…

This trial tests a new dual-function semirigid thoracoscope against the standard rigid thoracoscope for diagnosing pleural disease (fluid buildup around the lungs). The new device is designed to be easier to maneuver and potentially less painful while still obtaining large tissue…

This study tests an artificial intelligence (AI) system that reads chest X-rays in real time to help doctors quickly find misplaced breathing or feeding tubes and lung collapse (pneumothorax). The trial will involve about 10,900 patients in emergency and intensive care units. The…

This study tests whether starting with a less invasive ultrasound-guided biopsy can match the accuracy of immediate thoracoscopy (a camera-guided biopsy) for diagnosing unexplained fluid around the lungs. 420 adults with this condition will be randomly assigned to either the step…

This study tests a new liquid biopsy that measures TB DNA in fluid from around the lungs to diagnose tuberculous pleuritis, a common form of TB. Current methods often require invasive tissue biopsies or have low accuracy. The trial will enroll 350 adults with new-onset pleural ef…

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This study tests whether an ultrasound-guided nerve block (erector spinae plane block) provides better pain relief than standard local anesthesia during a lung procedure called medical thoracoscopy. One hundred adults scheduled for this procedure will be randomly assigned to rece…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This study looks at whether removing the chest tube right after lung surgery (called a tubeless strategy) helps patients recover faster with less pain. About 300 adults having a specific type of lung surgery will be randomly assigned to one of three groups: standard chest tube, o…

This study looks at two methods of giving talc to treat fluid buildup or collapsed lung. About 160 people aged 12 and older will get either talc mixed with liquid or talc sprayed as a powder. The goal is to see which method works better, causes fewer side effects, and leads to a …

This study compares outpatient (home) care to standard hospital care for people having their first large collapsed lung. 386 adults aged 18-50 will be randomly assigned to either go home with a small chest tube and valve or stay in the hospital. The goal is to see if home treatme…

This study will test whether wearable sensors can accurately monitor movement problems in people with progressive supranuclear palsy (PSP) and dementia with Lewy bodies (DLB). About 60 participants will wear small sensors on their chest, ankles, and wrists while doing simple task…

This observational study will use bedside ultrasound to measure the diaphragm—the main breathing muscle—in 120 adults with liver cirrhosis and compare them to healthy volunteers. Researchers want to see if cirrhosis weakens the diaphragm and if removing fluid from the belly impro…

This study collects blood and tissue samples from 110 adults with advanced lung, head and neck, or mesothelioma cancer. The samples are stored in a biobank to help scientists study cancer genes and find better ways to predict treatment outcomes. Participants do not receive any ex…

This study checks if a Turkish version of the Respiratory Distress Observation Scale (RDOS) accurately measures breathing distress in critically ill patients who cannot speak. Researchers will compare RDOS scores with end-tidal carbon dioxide levels, an objective breathing measur…

This study compares two techniques for closing the wound after a chest tube is removed: the purse-string suture and the plug method. Researchers want to see which one leads to better healing, fewer complications like air leaks or infections, and higher patient satisfaction. About…

This observational study will follow about 3,400 adults receiving single-shot regional anesthesia (nerve blocks) for surgery. Researchers aim to measure how often complications like nerve injury, bleeding, or lung puncture occur. The study does not test any new drug or treatment—…