Pleural disorder

This study tests whether washing the infected chest cavity with povidone-iodine (an antiseptic) helps adults with pleural empyema recover faster than using normal saline alone. Participants receive chest tube drainage plus daily irrigation with either povidone-iodine or saline. T…

This study tested a new drug called PM8002, which targets two proteins that help cancer grow, combined with standard chemotherapy. It involved 31 adults with a rare cancer called malignant mesothelioma that could not be removed by surgery. The goal was to see if the combination s…

This completed study looked at 80 people with empyema, a serious lung infection. Researchers compared two different antibiotic combinations to see which was safer and more effective. The goal is to help doctors choose the best treatment for this condition.

This early-phase trial tested whether giving the immunotherapy drug pembrolizumab (Keytruda) after radiation therapy is safe for people with malignant pleural mesothelioma, a rare cancer of the lung lining. Twenty-five participants received radiation followed by pembrolizumab. Th…

This study tested whether adding the immunotherapy drug atezolizumab to standard treatment (bevacizumab plus chemotherapy) helps people with advanced malignant pleural mesothelioma live longer. The trial involved 400 adults whose cancer could not be removed by surgery. Researcher…

This study tested a drug called pembrolizumab in 65 people with malignant mesothelioma, a rare cancer of the lining around the lungs or abdomen. The drug works by helping the immune system attack cancer cells. The goal was to see if it could shrink tumors or slow the disease, but…

This completed Phase 2b/3 trial tested the drug AMX0035 in 139 people with progressive supranuclear palsy (PSP), a rare brain disease that causes problems with balance, movement, and thinking. The study compared the drug to a placebo to see if it could slow the disease. The resul…

This phase 3 trial tested a new approach for malignant pleural mesothelioma, a rare and aggressive cancer of the lung lining. Researchers gave 53 patients a gene therapy (rAd-IFN) injected into the chest cavity, along with the drugs celecoxib and gemcitabine. The goal was to see …

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This early-phase trial tested a light-measuring system used during photodynamic therapy (PDT) for people with malignant mesothelioma, non-small cell lung cancer, or other pleural cancers. Nine participants received the drug porfimer sodium, which becomes active when exposed to li…

This study looked at whether a short, intense course of chest radiation given just before surgery can kill cancer cells and prevent them from spreading outside the chest during the operation. It involved 104 people with malignant pleural mesothelioma, a cancer linked to asbestos.…

This study compared two treatments for pleural infection, a serious lung condition where infected fluid builds up. One group received standard fibrinolytic drugs (alteplase and DNase) to break down clots, while the other group received simple saline (salt water) irrigation to flu…

This study tested whether continuing chemotherapy with gemcitabine after initial treatment can help patients with diffuse pleural mesothelioma keep their cancer under control longer. 64 patients who responded to first-line chemo were randomly assigned to receive gemcitabine or no…

This pilot study tested whether adding intrapleural photodynamic therapy (PDT) to standard surgery and chemotherapy is safe and feasible for patients with malignant pleural mesothelioma. Six participants received a light-sensitive drug followed by laser light inside the chest cav…

This study tested whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) works better than standard chemotherapy for Chinese patients with advanced pleural mesothelioma, a rare cancer of the lung lining. 102 patients who could not have surgery were randomly a…

This study tested whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with advanced pleural mesothelioma live longer. The trial included 214 adults whose cancer could not be removed by surgery. Participants received either the combination or a s…

This study tested an experimental drug called RC88 in 198 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could shrink tumors or slow their growth. The study was completed and looked at sid…

This phase II trial tested a drug called Bintrafusp alfa (M7824) in 47 people with advanced pleural mesothelioma that had worsened after platinum-based chemotherapy. The drug aims to block two proteins that help tumors grow. Researchers measured how long patients lived without th…

This study tested a new way to deliver chemotherapy directly to the tumor in adults with malignant pleural mesothelioma that cannot be removed by surgery. The treatment, called transarterial chemoperfusion, uses a combination of three drugs (cisplatin, methotrexate, and gemcitabi…

This early-phase trial tested a new treatment called CTX131 for adults with advanced solid tumors that have not responded to standard therapies. The treatment uses donor immune cells that are gene-edited to target a protein called CD70 found on cancer cells. The study enrolled 19…

This study tested an AI tool called Carebot AI CXR to see how well it spots lung problems like collapsed lungs, nodules, and fluid buildup on chest X-rays. Researchers compared the AI's performance to that of human radiologists using 956 patient X-rays. The goal was to see if the…

This study looked at whether measuring TB DNA in fluid from around the lungs (pleural fluid) can quickly and accurately diagnose tuberculosis. Researchers tested fluid from 329 adults with lung fluid buildup. The goal was to see if this DNA test works better than standard tests, …

This study looked at two ways to quickly tell if fluid around the lungs (pleural effusion) is cancerous during a procedure called thoracoscopy. Doctors visually inspected the lining of the lung and also did a rapid test on biopsy samples right in the procedure room. The goal was …

This study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…

This study collected tissue and blood samples from 143 people with malignant pleural effusion (cancer that has spread to the lining of the chest). The goal was to create a biobank for future research into why cancer cells in the chest may differ from the original tumor. No treatm…

This study tested whether a device called electrical impedance tomography (EIT) can detect collapsed lung (atelectasis) or air leaks (pneumothorax) in newborn babies. Researchers placed the EIT system at the bedside of 20 infants in the NICU and compared its readings to chest X-r…

This completed study looked at 1200 patients who had a CT-guided needle biopsy of a lung nodule at St. Olavs Hospital between 2012 and 2023. The goal was to track how often complications like a collapsed lung (pneumothorax), lung bleeding, or air embolism happen. By analyzing the…

This study surveyed 418 respiratory doctors in the Asia-Pacific region to understand how they diagnose tuberculous pleuritis, a type of TB that affects the lining around the lungs. The goal was to see which tests are used, how available they are, and how doctors decide to start t…

This completed study looked at 300 patients with pleural effusion—fluid buildup around the lungs—to find out what caused it. Researchers reviewed medical records to classify the fluid type and identify underlying conditions like heart failure, infection, or cancer. The goal was t…

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study looked at 104 patients to find the optimal number of tissue samples (biopsies) to take during a pleuroscopy, a procedure to examine the lining of the lungs. The goal was to see how many biopsies are needed to make a diagnosis and to get enough tissue for further testin…

This study looked at over 1,000 patients who had a lung nodule marked with a special trimmed wire before surgery. The goal was to see if this technique raised the risk of a collapsed lung (pneumothorax) compared to using dye alone. Researchers found that the trimmed wire did not …

This completed study looked at how the antibiotics amoxicillin and clavulanic acid get into the infected fluid around the lungs in people with pleural infections. Eleven adults with complicated infections had chest tubes placed and received the antibiotics. Researchers measured a…

This study tested whether an AI tool called Lunit INSIGHT CXR helps healthcare professionals read chest X-rays more accurately and quickly. Thirty doctors and radiographers reviewed 500 past chest X-rays from two UK hospitals, once with and once without AI help. The goal was to s…

This study measured the pressure inside the chest in 37 adults with a collapsed lung (pneumothorax) who needed a chest tube. Researchers wanted to see if these pressure readings could help predict who would need additional treatments like surgery or a valve. The study was observa…

This study looks back at 204 patients with untreated, inoperable malignant pleural mesothelioma who received a combination of two immunotherapy drugs, nivolumab and ipilimumab, through an early access program in France. Researchers will collect data from medical records to see ho…

This study looked at 350 patients who had surgery (decortication) to treat severe lung infections called empyema, including cases caused by tuberculosis and drug-resistant bacteria. The goal was to understand the types of germs causing these infections and how they affect recover…