New hope for mesothelioma patients: experimental drug tested in 47-person trial

NCT ID NCT05005429

Completed Disease control Sponsor: Fundación GECP Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tested a drug called Bintrafusp alfa (M7824) in 47 people with advanced pleural mesothelioma that had worsened after platinum-based chemotherapy. The drug aims to block two proteins that help tumors grow. Researchers measured how long patients lived without their cancer getting worse and checked for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bintrafusp alfa (M7824)
What this could lead to: If successful, this could offer a new treatment option for advanced mesothelioma patients who have already tried chemotherapy.
What could go wrong: This is a small, early-phase trial with only 47 participants, so results may not apply to everyone. The drug may not slow tumor growth or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

malignant pleural mesothelioma mesothelioma Mesothelioma, Malignant pleural mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MESOTHELIOMA; LUNG

Contacts and locations

Locations

Hospital Clínico Universitario de Valladolid

Valladolid, Valladolid, 47003, Spain
Hospital Clínico de Valencia

Valencia, Valencia, 46010, Spain
Hospital General Universitario de Alicante

Alicante, Alicante, 03010, Spain
Hospital Parc Taulí

Barcelona, Barcelona, 08208, Spain
Hospital Universitari Vall d' Hebron

Barcelona, Barcelona, 08035, Spain
Hospital Universitario Central de Asturias

Oviedo, Oviedo, 33011, Spain
Hospital Universitario Fundación Jiménez Díaz

Madrid, Madrid, 28040, Spain
Hospital Universitario Lucus Augusti

Lugo, Lugo, 27003, Spain
Hospital Universitario Puerta de Hierro

Majadahonda, Madrid, 28222, Spain
Hospital Universitario Virgen De La Victoria

Málaga, Málaga, 29010, Spain
Hospital de Basurto

Bilbao, Bilbao, 48013, Spain
Hospitalario Universitario A Coruña

A Coruña, La Coruña, 15006, Spain
ICO Badalona, Hospital Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain
ICO Girona, Hospital Josep Trueta

Girona, Girona, 17007, Spain
ICO Hospitalet

L'Hospitalet de Llobregat, Barcelona, 08908, Spain

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