New combo therapy for mesothelioma: radiation plus surgery under study
NCT ID NCT04028570
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a new approach for people with malignant pleural mesothelioma, a rare lung cancer. It combines high-dose radiation (including a special boost to target bulky tumors) with surgery to remove the affected tissue. The main goal is to find the highest safe radiation dose that doesn't cause severe lung injury. Only 15 participants are enrolled, making this an early-stage feasibility study.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (background and boost radiation)
- What this could lead to
- If successful, this could point toward a safer way to combine high-dose radiation with surgery for mesothelioma, potentially improving disease control.
- What could go wrong
- This is a very small, early feasibility study with only 15 participants, so results may not apply broadly. There is a risk of serious lung injury from the radiation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Princess Margaret Hospital, University Health Network
Toronto, Ontario, M5G 2M9, Canada
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