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Could a simple chemical wash replace surgery for trapped lungs?

NCT ID NCT07713329

Disease control Sponsor: Delta University for Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This study tests whether injecting a diluted hydrogen peroxide solution or steroids into the chest can break up scar tissue and free a trapped lung, compared to a standard surgical scraping procedure (thoracoscopy). The trial enrolls adults aged 18-62 with a lung infection that has caused fluid pockets and adhesions. Success is measured by a combined score of lung expansion, diaphragm movement, and fluid drainage one week after treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intrapleural hydrogen peroxide or intrapleural corticosteroids
What this could lead to
If successful, this could offer a cheaper, simpler treatment for trapped lungs due to infection, reducing the need for specialized surgery.
What could go wrong
This is a small early-phase trial (36 people), so results may not apply broadly. Hydrogen peroxide in the chest carries risks like air embolism or tissue damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

36 people

The number who actually took part.

Started

Mar 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 62 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Inclusion Criteria: 1. Patient age between 18 and 62 years inclusive. 2. Presence of a unilateral complicated parapneumonic pleural effusion (CPPE) requiring pleurolytic intervention. 3. Imaging-confirmed pleural loculation on chest ultrasonography or computed tomography (CT). 4. Pleural fluid biochemical or microbiological indicators of complicated effusion, defined by at least one of the following: pleural fluid pH \< 7.2, glucose \< 60 mg/dL, and/or a positive Gram stain or culture. 5. Absolute histopathological or cytological exclusion of malignant and tuberculous pleural disease prior to enrollment (verified via closed pleural biopsy and/or image-guided pleural biopsy based on clinical presentation). Exclusion Criteria: 1. Confirmed malignant pleural effusion or features highly suggestive of malignancy (e.g., pleural nodularity, circumferential pleural thickening \> 10 mm, mediastinal pleural involvement, or associated pulmonary masses) not yet fully evaluated. 2. Tuberculous pleural effusion. 3. Transudative pleural effusion. 4. Frozen chest syndrome or chronic trapped lung. 5. Pregnancy. 6. Known bleeding diathesis or uncorrected coagulopathy. 7. Patient refusal or inability to provide written informed consent.

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Conditions

The condition(s) this trial relates to.

empyema Pleural Effusion pleural empyema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pleural adhesions Pleural effusion Pleural empyema Pleural infection

Contacts and locations

Locations

  • Delta university for science and technology

    Gamasa, 1234, Egypt

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