Immunotherapy combo before surgery shows promise for tough mesothelioma

NCT ID NCT05647265

Recruiting now Disease control Sponsor: Alliance for Clinical Trials in Oncology Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 06, 2026 · Updated 4 times

Summary

This phase II trial is testing whether giving two immunotherapy drugs, nivolumab and ipilimumab, before surgery can help control sarcomatoid mesothelioma, a rare and aggressive cancer of the lung lining. The study will enroll 26 people with stage I to IIIa disease. The main goals are to see how many patients can successfully undergo surgery after immunotherapy and how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nivolumab and ipilimumab (immunotherapy drugs)
What this could lead to: If successful, this approach could improve surgery rates and delay cancer progression for people with this aggressive mesothelioma type.
What could go wrong: This is a small, early-phase trial with only 26 participants. Immunotherapy can cause serious side effects, and the treatment may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pleural biphasic mesothelioma pleural sarcomatoid mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PLEURAL BIPHASIC MESOTHELIOMA PLEURAL SARCOMATOID MESOTHELIOMA

Contacts and locations

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Locations

Alaska Breast Care and Surgery LLC
RECRUITING

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC
RECRUITING

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care
RECRUITING

Anchorage, Alaska, 99508, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
RECRUITING

Las Vegas, Nevada, 89135, United States

Contact Email: •••••@•••••
Anchorage Associates in Radiation Medicine
RECRUITING

Anchorage, Alaska, 98508, United States
Anchorage Radiation Therapy Center
SUSPENDED

Anchorage, Alaska, 99504, United States
Ann M Wierman MD LTD
SUSPENDED

Las Vegas, Nevada, 89128, United States
Bay Area Hospital
RECRUITING

Coos Bay, Oregon, 97420, United States
Beebe Health Campus
ACTIVE_NOT_RECRUITING

Rehoboth Beach, Delaware, 19971, United States
Beebe Medical Center
ACTIVE_NOT_RECRUITING

Lewes, Delaware, 19958, United States
Beebe South Coastal Health Campus
ACTIVE_NOT_RECRUITING

Millville, Delaware, 19967, United States
Cancer Care Northwest - Spokane South
RECRUITING

Spokane, Washington, 99202, United States

Contact Email: •••••@•••••
Cancer Care Northwest-North Spokane
RECRUITING

Spokane, Washington, 99218, United States

Contact Email: •••••@•••••
Cancer Care Northwest-Valley
RECRUITING

Spokane, Washington, 99216, United States

Contact Email: •••••@•••••
Cancer and Blood Specialists-Henderson
SUSPENDED

Henderson, Nevada, 89052, United States
Carle Cancer Center
RECRUITING

Urbana, Illinois, 61801, United States

Contact Email: •••••@•••••
Carle Physician Group-Effingham
RECRUITING

Effingham, Illinois, 62401, United States

Contact Email: •••••@•••••
Carle Physician Group-Mattoon/Charleston
RECRUITING

Mattoon, Illinois, 61938, United States

Contact Email: •••••@•••••
Carle at The Riverfront
RECRUITING

Danville, Illinois, 61832, United States

Contact Email: •••••@•••••
Carson Tahoe Regional Medical Center
RECRUITING

Carson City, Nevada, 89703, United States

Contact Email: •••••@•••••
Christiana Care - Union Hospital
ACTIVE_NOT_RECRUITING

Elkton, Maryland, 21921, United States
Christiana Care Health System-Christiana Hospital
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19718, United States
Christiana Care Health System-Concord Health Center
ACTIVE_NOT_RECRUITING

Chadds Ford, Pennsylvania, 19317, United States
Christiana Care Health System-Wilmington Hospital
ACTIVE_NOT_RECRUITING

Wilmington, Delaware, 19801, United States
Clackamas Radiation Oncology Center
RECRUITING

Clackamas, Oregon, 97015, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada
RECRUITING

Las Vegas, Nevada, 89148, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada - Central Valley
RECRUITING

Las Vegas, Nevada, 89169, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada - Henderson
RECRUITING

Henderson, Nevada, 89052, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada - Northwest
RECRUITING

Las Vegas, Nevada, 89128, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada - Town Center
RECRUITING

Las Vegas, Nevada, 89144, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada-Horizon Ridge
RECRUITING

Henderson, Nevada, 89052, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada-Southeast Henderson
RECRUITING

Henderson, Nevada, 89074, United States

Contact Email: •••••@•••••
Comprehensive Cancer Centers of Nevada-Summerlin
RECRUITING

Las Vegas, Nevada, 89144, United States

Contact Email: •••••@•••••
Delaware Clinical and Laboratory Physicians PA
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19713, United States
Duke Cancer Center Raleigh
RECRUITING

Raleigh, North Carolina, 27609, United States

Contact Email: •••••@•••••
Duke Cancer Center Southpoint
RECRUITING

Durham, North Carolina, 27713, United States

Contact Email: •••••@•••••
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Helen F Graham Cancer Center
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19713, United States
Hope Cancer Care of Nevada
RECRUITING

Las Vegas, Nevada, 89103, United States

Contact Email: •••••@•••••
Hope Cancer Care of Nevada-Pahrump
RECRUITING

Pahrump, Nevada, 89048, United States

Contact Email: •••••@•••••
Kadlec Clinic Hematology and Oncology
RECRUITING

Kennewick, Washington, 99336, United States

Contact Email: •••••@•••••
Katmai Oncology Group
RECRUITING

Anchorage, Alaska, 99508, United States
Kingman Regional Medical Center
RECRUITING

Kingman, Arizona, 86401, United States

Contact Email: •••••@•••••
Las Vegas Cancer Center-Henderson
SUSPENDED

Henderson, Nevada, 89052, United States
Las Vegas Cancer Center-Medical Center
SUSPENDED

Las Vegas, Nevada, 89148-2405, United States
Las Vegas Prostate Cancer Center
SUSPENDED

Las Vegas, Nevada, 89113, United States
Las Vegas Urology - Cathedral Rock
SUSPENDED

Las Vegas, Nevada, 89128, United States
Las Vegas Urology - Green Valley
SUSPENDED

Henderson, Nevada, 89074, United States
Las Vegas Urology - Pebble
SUSPENDED

Henderson, Nevada, 89074, United States
Las Vegas Urology - Pecos
SUSPENDED

Las Vegas, Nevada, 89074, United States
Las Vegas Urology - Smoke Ranch
SUSPENDED

Las Vegas, Nevada, 89128, United States
Las Vegas Urology - Sunset
SUSPENDED

Las Vegas, Nevada, 89113, United States
Mayo Clinic Hospital in Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida
RECRUITING

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical Oncology Hematology Consultants PA
ACTIVE_NOT_RECRUITING

Newark, Delaware, 19713, United States
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
RECRUITING

Yakima, Washington, 98902, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Oncology Las Vegas - Henderson
RECRUITING

Henderson, Nevada, 89074, United States

Contact Email: •••••@•••••
Oncology Las Vegas - Tenaya
RECRUITING

Las Vegas, Nevada, 89128, United States

Contact Email: •••••@•••••
OptumCare Cancer Care at Charleston
RECRUITING

Las Vegas, Nevada, 89102, United States

Contact Email: •••••@•••••
OptumCare Cancer Care at Fort Apache
RECRUITING

Las Vegas, Nevada, 89183, United States

Contact Email: •••••@•••••
OptumCare Cancer Care at MountainView
RECRUITING

Las Vegas, Nevada, 89128, United States

Contact Email: •••••@•••••
Overlake Medical Center
SUSPENDED

Bellevue, Washington, 98004, United States
PCR Oncology
RECRUITING

Arroyo Grande, California, 93420, United States

Contact Email: •••••@•••••
PeaceHealth Saint John Medical Center
RECRUITING

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center
RECRUITING

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center
RECRUITING

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center
RECRUITING

Sedro-Woolley, Washington, 98284, United States
Providence Alaska Medical Center
RECRUITING

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic
SUSPENDED

Clackamas, Oregon, 97015, United States
Providence Hood River Memorial Hospital
RECRUITING

Hood River, Oregon, 97031, United States

Contact Email: •••••@•••••
Providence Medical Foundation - Santa Rosa
RECRUITING

Santa Rosa, California, 95403, United States
Providence Newberg Medical Center
RECRUITING

Newberg, Oregon, 97132, United States

Contact Email: •••••@•••••
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
Providence Queen of The Valley
RECRUITING

Napa, California, 94558, United States
Providence Regional Cancer Partnership
RECRUITING

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen
RECRUITING

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia
RECRUITING

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey
RECRUITING

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton
SUSPENDED

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm
SUSPENDED

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
RECRUITING

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center
RECRUITING

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center
RECRUITING

Portland, Oregon, 97225, United States

Contact Email: •••••@•••••
Providence Santa Rosa Memorial Hospital
RECRUITING

Santa Rosa, California, 95405, United States
Providence Willamette Falls Medical Center
RECRUITING

Oregon City, Oregon, 97045, United States

Contact Email: •••••@•••••
Radiation Oncology Associates
SUSPENDED

Reno, Nevada, 89509, United States
Radiation Oncology Centers of Nevada Central
RECRUITING

Las Vegas, Nevada, 89106, United States

Contact Email: •••••@•••••
Radiation Oncology Centers of Nevada Southeast
RECRUITING

Las Vegas, Nevada, 89119, United States

Contact Email: •••••@•••••
Renown Regional Medical Center
RECRUITING

Reno, Nevada, 89502, United States
Rush-Copley Healthcare Center
RECRUITING

Yorkville, Illinois, 60560, United States

Contact Email: •••••@•••••
Rush-Copley Medical Center
RECRUITING

Aurora, Illinois, 60504, United States
Saint Charles Health System
RECRUITING

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond
RECRUITING

Redmond, Oregon, 97756, United States
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls
RECRUITING

Twin Falls, Idaho, 83301, United States
Saint Mary's Regional Medical Center
RECRUITING

Reno, Nevada, 89503, United States

Contact Email: •••••@•••••
Saint Patrick Hospital - Community Hospital
RECRUITING

Missoula, Montana, 59802, United States
Skagit Regional Health Cancer Care Center
RECRUITING

Mount Vernon, Washington, 98274, United States

Contact Email: •••••@•••••
Summerlin Hospital Medical Center
RECRUITING

Las Vegas, Nevada, 89144, United States

Contact Email: •••••@•••••
Sunrise Hospital and Medical Center
RECRUITING

Las Vegas, Nevada, 89109, United States

Contact Email: •••••@•••••
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States
Swedish Medical Center-Ballard Campus
RECRUITING

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill
RECRUITING

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

Contact Email: •••••@•••••
UT Southwestern Clinical Center at Richardson/Plano
RECRUITING

Richardson, Texas, 75080, United States
UT Southwestern Simmons Cancer Center - RedBird
RECRUITING

Dallas, Texas, 75237, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Email: •••••@•••••
University Cancer Center
SUSPENDED

Las Vegas, Nevada, 89169, United States
University Medical Center of Southern Nevada
RECRUITING

Las Vegas, Nevada, 89102, United States

Contact Email: •••••@•••••
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Minnesota/Masonic Cancer Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
Urology Specialists of Nevada - Central
RECRUITING

Las Vegas, Nevada, 89106, United States

Contact Email: •••••@•••••
Urology Specialists of Nevada - Green Valley
RECRUITING

Henderson, Nevada, 89074, United States

Contact Email: •••••@•••••
Urology Specialists of Nevada - Northwest
RECRUITING

Las Vegas, Nevada, 89128, United States

Contact Email: •••••@•••••
Urology Specialists of Nevada - Southwest
RECRUITING

Las Vegas, Nevada, 89113, United States

Contact Email: •••••@•••••
Valley Medical Center
RECRUITING

Renton, Washington, 98055, United States

Contact Email: •••••@•••••

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