Could a single daily dose beat a double for lung infection treatment?
NCT ID NCT07095361
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving medication once a day through a chest tube works as well as giving it twice a day for people with serious infections around the lungs. Participants are adults already in the hospital with a chest tube draining infected fluid. They will be randomly assigned to receive the enzyme treatment either once or twice daily, and researchers will compare outcomes like need for surgery and survival at 90 days.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dartmouth Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03766, United States
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
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UNC Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27514, United States
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Yale New Haven Hospital
RECRUITINGNew Haven, Connecticut, 06510, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a simple chemical wash replace surgery for trapped lungs?
- Could a simple antiseptic wash beat chest infections without surgery?
- Saline wash may offer safer way to treat lung infections
- Scientists probe link between lung fluid and breathlessness
- New app aims to cut hospital stays for lung patients