New drug cocktail could simplify treatment for dangerous lung lining infection

This study tests two different drug combinations for pleural infection, a serious infection of the lung lining that often requires surgery. The standard treatment uses two drugs (alteplase and DNase) given through a chest tube. This trial compares that to a new combination using alteplase and Tyloxapol. The goal is to see if the new combo works as well or better at clearing the infection and reducing the need for surgery. The study will involve 80 adults with pleural infection who have poor drainage from a chest tube.